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  • BMS-509744
    • BMS 509744; BMS509744
    货号: abs811070
    CAS号: 439575-02-7
    分子式: C32H41N5O4S2
    分子量: 623.83
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs811070-5mg 1-2周 ¥2547.00
    - +
    abs811070-10mg 1-2周 ¥4624.00
    - +
    abs811070-50mg 1-2周 ¥16230.00
    - +
    大包装询价
    产品描述
    描述

    The ITK inhibitor BMS-509744 disrupts several aspects of HIV replication.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    BMS 509744; BMS509744
    可溶性/溶解性
    DMSO: 21.9 mg/mL
    生物活性
    靶点
    Itk
    In vitro(体外研究)
    BMS-509744 reduces T-cell receptor-induced functions including PLCγ1 tyrosine phosphorylation, calcium mobilization, IL-2 secretion, and T-cell proliferation in vitro in both human and mouse cells. BMS-488516 and BMS-509744 potently inhibit Itk in vitro with IC50 values of 96 and 19 nM, respectively. Both compounds exhibit competitive kinetics with respect to ATP, suggesting that they bind to the ATP binding site of the Itk kinase domain.
    In vivo(体内研究)
    BMS-509744 and BMS-488516 suppress the production of IL-2 induced by anti-T-cell receptor antibody administered to mice. BMS-509744 exhibits a 50% inhibitory capacity when dosed at 50 mg/kg, irrespective of the amount of induction antibody. BMS-509744 also significantly diminishes lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.
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