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  • BI605906
    • BI 605906
    货号: abs811360
    CAS号: 960293-88-3
    分子式: C17H22F2N4O3S2
    分子量: 432.51
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs811360-5mg 1-2周 ¥3032.00
    - +
    abs811360-10mg 1-2周 ¥5458.00
    - +
    大包装询价
    产品描述
    描述

    BI605906 is a novel inhibitors of the IKK beta.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    BI 605906
    可溶性/溶解性
    DMSO: ≥ 29 mg/mL
    生物活性
    靶点
    IKK
    In vitro(体外研究)
    BI605906 is an inhibitor of IKKβ with improved selectivity. BI605906 inhibits IKKβ in vitro with an IC50 value of 380 nM when assayed at 0.1 mM ATP. The only other protein kinase that is inhibited of over 100 tested, which include IKKα, IKKε and TBK1, is the insulin-like growth factor 1 (IGF1) receptor (IC50=7.6 μM). BI605906 partially inhibits the IL-1-stimulated activation of IKKε/TBK1. In primary mouse hepatocytes, Metformin treatment for 3 hours suppresses TNFα-induced degradation of the NF-κB negative regulator IκB, while modulating AMPK and MTOR signaling in a dose-dependent manner. The magnitude of the effect on IκB is comparable with BI605906. Unlike Metformin, BI605906 (10 μM ) does not suppress signaling downstream of mTOR nor does it activate AMPK. TNF-α-dependent expression of CINC-1/CXCL1, CXCL2, IL-1β, and IL-6 is strongly inhibited by both Metformin and BI605906 (10 μM).
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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