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  • Berberine chloride hydrate
  • 货号: abs822557
    CAS号: 68030-18-2
    分子式: C20H20ClNO5
    分子量: 389.83
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    货号-规格 货期 价格 数量
    abs822557-5g 4周 ¥756.00
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    产品描述
    描述
    Berberine chloride hydrate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
    纯度
    98%
    储存/保存方法
    store at -20℃ for one year(Powder)
    生物活性
    靶点
    ROSDNA topoisomerase
    In vitro(体外研究)
    Berberine (1.25-160 μM; 72 hours) has potential inhibitory effects on the proliferation of four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29. Berberine (1.25-160 μM; 24-72 hours) induces a time- and dose-dependent inhibition of LoVo cell growth. LoVo cells are exposure to Berberine (10-80 μM) for 24 h. Cell cycle analysis of 40 μM Berberine-treated LoVo cells by flow cytometry shows accumulation of cells in the G2/M phase.Berberine (10-80 μM) suppresses cyclin B1, cdc2 and cdc25c protein expression after 24 h, especially at the dose of 80.0 μM.Cell Proliferation AssayCell Line:Four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29Concentration:1.25, 2.5, 5, 10, 20, 40, 80, and 160 μMIncubation Time:72 hoursResult:Inhibited the proliferation of four cell lines. The IC50 ranged from 40.8±4.1 μM (LoVo) to 98.6±2.9 μM (HCT116).
    In vivo(体内研究)
    Berberine (1.25-160 μM; 72 hours) has potential inhibitory effects on the proliferation of four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29. Berberine (1.25-160 μM; 24-72 hours) induces a time- and dose-dependent inhibition of LoVo cell growth. LoVo cells are exposure to Berberine (10-80 μM) for 24 h. Cell cycle analysis of 40 μM Berberine-treated LoVo cells by flow cytometry shows accumulation of cells in the G2/M phase.Berberine (10-80 μM) suppresses cyclin B1, cdc2 and cdc25c protein expression after 24 h, especially at the dose of 80.0 μM.Cell Proliferation AssayCell Line:Four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29Concentration:1.25, 2.5, 5, 10, 20, 40, 80, and 160 μMIncubation Time:72 hoursResult:Inhibited the proliferation of four cell lines. The IC50 ranged from 40.8±4.1 μM (LoVo) to 98.6±2.9 μM (HCT116).
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