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  • Bay 11-7082

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    • Bay11-7082;BAY11-7082;BAY 11-7082;BAY117082
    货号: abs810013
    CAS号: 19542-67-7
    分子式: C10H9NO2S
    分子量: 207.25
    产品说明书
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    货号-规格 货期 价格 数量
    abs810013-5mg 现货 ¥453.00 ¥136.00
    - +
    abs810013-10mg 现货 ¥579.00 ¥174.00
    - +
    abs810013-25mg 现货 ¥992.00 ¥298.00
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    大包装询价
    产品描述
    描述

    BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.

    纯度
    >98 %
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Bay11-7082;BAY11-7082;BAY 11-7082;BAY117082
    外观
    White to off white solid
    可溶性/溶解性
    DMSO :41 mg/mL (197.82 mM)
    Ethanol :10 mg/mL (48.25 mM)
    生物活性
    靶点
    E2-conjugating enzymes;IκBα phosphorylation
    In vitro(体外研究)
    Bay 11-7082, an inhibitor of NF-κB, induces apoptosis of HTLV-I-infected T-cell lines but only negligible apoptosis of HTLV-I-negative T cells. Bay 11-7082 rapidly and efficiently reduces the DNA binding of NF-κB in HTLV-I-infected T-cell lines and down-regulated the expression of the antiapoptotic gene, Bcl-xL, regulated by NF-κB. Bay 11-7082 selectively inhibits Tax-induced NF-κB activity in a human T-cell line. BAY 11-7082 inhibits NFκB signalling and is recently shown to inhibit the majority of E2 and E3 ligases tested by reacting covalently with the catalytic cysteine residues. Moreover, BAY 11-7082 also inhibits several tyrosine phosphatases by reacting with catalytic Cys residue of these enzymes. NSC 697923 is originally shown to inhibit the E2 ligase Ubc13-Uev1A. BAY 11-7082 inhibits the phosphorylation of IκBα and activation of NF-κB, induces the death of HBL-1 cells. BAY 11-7082 completely suppresses the LPS-stimulated and IL-1-stimulated phosphorylation of the activation loop of IKKβ. BAY 11-7082 acts by inhibiting TNF-α-induced phosphorylation of IκB-α, resulting in decreased NF-κB and decreases expression of adhesion molecules.
    In vivo(体内研究)
    BAY 11-7082 (2.5 mg/kg and 5 mg/kg; intratumoral injection; twice-weekly for 21 days ) significantly suppresses tumor growth in a dose-dependent manner.
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    • 实验方法 实验条件
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