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  • Bay 11-7082
    • Bay11-7082;BAY11-7082;BAY 11-7082;BAY117082
    货号: abs810013
    CAS号: 19542-67-7
    分子式: C10H9NO2S
    分子量: 207.25
    产品说明书
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    货号-规格 货期 价格 数量
    abs810013-5mg 1-2周 ¥453.00
    - +
    abs810013-10mg 现货 ¥579.00
    - +
    abs810013-25mg 现货 ¥992.00
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    大包装询价
    产品描述
    描述

    BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.

    纯度
    >98 %
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    Bay11-7082;BAY11-7082;BAY 11-7082;BAY117082
    外观
    白色至类白色粉末
    可溶性/溶解性
    DMSO :41 mg/mL (197.82 mM)

    Ethanol :10 mg/mL (48.25 mM)
    生物活性
    靶点
    E2-conjugating enzymes;IκBα phosphorylation
    In vitro(体外研究)
    Bay 11-7082, an inhibitor of NF-κB, induces apoptosis of HTLV-I-infected T-cell lines but only negligible apoptosis of HTLV-I-negative T cells. Bay 11-7082 rapidly and efficiently reduces the DNA binding of NF-κB in HTLV-I-infected T-cell lines and down-regulated the expression of the antiapoptotic gene, Bcl-xL, regulated by NF-κB. Bay 11-7082 selectively inhibits Tax-induced NF-κB activity in a human T-cell line. BAY 11-7082 inhibits NFκB signalling and is recently shown to inhibit the majority of E2 and E3 ligases tested by reacting covalently with the catalytic cysteine residues. Moreover, BAY 11-7082 also inhibits several tyrosine phosphatases by reacting with catalytic Cys residue of these enzymes. NSC 697923 is originally shown to inhibit the E2 ligase Ubc13-Uev1A. BAY 11-7082 inhibits the phosphorylation of IκBα and activation of NF-κB, induces the death of HBL-1 cells. BAY 11-7082 completely suppresses the LPS-stimulated and IL-1-stimulated phosphorylation of the activation loop of IKKβ. BAY 11-7082 acts by inhibiting TNF-α-induced phosphorylation of IκB-α, resulting in decreased NF-κB and decreases expression of adhesion molecules.
    参考文献
    参考文献
    [1] Melisi D, et al. Expert Opin Ther Targets, 2007, 11(2), 133-144.
    [2] Gastonguay A, et al. Cancer Biol Ther, 2012, 13(8), 647-656.
    [3] Miwatashi S, et al. J Med Chem, 2005, 48(19), 5966-5979.
    [4] Mori N, et al. Blood, 2002, 100(5), 1828-1834.
    [5] Goffi F, et al. Neurosci Lett, 2005, 377(3), 147-151.
    [6] Strickson S, et al. Biochem J. 2013, 451(3), 427-437.
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