- Bay11-7082;BAY11-7082;BAY 11-7082;BAY117082
货号: abs810013
货号-规格 | 货期 | 价格 | 数量 |
abs810013-5mg | 1-2周 | ¥453.00 | - + |
abs810013-10mg | 现货 | ¥579.00 | - + |
abs810013-25mg | 现货 | ¥992.00 | - + |

产品描述 | ||
描述 | BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system. | |
纯度 | >98 % | |
储存/保存方法 | store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
基本信息 | ||
别名 | Bay11-7082;BAY11-7082;BAY 11-7082;BAY117082 | |
外观 | 白色至类白色粉末 | |
可溶性/溶解性 | DMSO :41 mg/mL (197.82 mM) Ethanol :10 mg/mL (48.25 mM) | |
生物活性 | ||
靶点 | E2-conjugating enzymes;IκBα phosphorylation | |
In vitro(体外研究) | Bay 11-7082, an inhibitor of NF-κB, induces apoptosis of HTLV-I-infected T-cell lines but only negligible apoptosis of HTLV-I-negative T cells. Bay 11-7082 rapidly and efficiently reduces the DNA binding of NF-κB in HTLV-I-infected T-cell lines and down-regulated the expression of the antiapoptotic gene, Bcl-xL, regulated by NF-κB. Bay 11-7082 selectively inhibits Tax-induced NF-κB activity in a human T-cell line. BAY 11-7082 inhibits NFκB signalling and is recently shown to inhibit the majority of E2 and E3 ligases tested by reacting covalently with the catalytic cysteine residues. Moreover, BAY 11-7082 also inhibits several tyrosine phosphatases by reacting with catalytic Cys residue of these enzymes. NSC 697923 is originally shown to inhibit the E2 ligase Ubc13-Uev1A. BAY 11-7082 inhibits the phosphorylation of IκBα and activation of NF-κB, induces the death of HBL-1 cells. BAY 11-7082 completely suppresses the LPS-stimulated and IL-1-stimulated phosphorylation of the activation loop of IKKβ. BAY 11-7082 acts by inhibiting TNF-α-induced phosphorylation of IκB-α, resulting in decreased NF-κB and decreases expression of adhesion molecules. | |
参考文献 | ||
参考文献 | [1] Melisi D, et al. Expert Opin Ther Targets, 2007, 11(2), 133-144.
[2] Gastonguay A, et al. Cancer Biol Ther, 2012, 13(8), 647-656. [3] Miwatashi S, et al. J Med Chem, 2005, 48(19), 5966-5979. [4] Mori N, et al. Blood, 2002, 100(5), 1828-1834. [5] Goffi F, et al. Neurosci Lett, 2005, 377(3), 147-151. [6] Strickson S, et al. Biochem J. 2013, 451(3), 427-437. | |
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