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  • Andrographolide
    • Andro; Andrographis
    货号: abs819432
    CAS号: 5508-58-7
    分子式: C20H30O5
    分子量: 350.45
    产品说明书
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    货号-规格 货期 价格 数量
    abs819432-50mg 1-2周 ¥276.00
    - +
    abs819432-100mg 1-2周 ¥386.00
    - +
    abs819432-500mg 1-2周 ¥1158.00
    - +
    大包装询价
    产品描述
    描述
    Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.
    纯度
    ≥98%
    储存/保存方法
    Store at -20° C
    基本信息
    别名
    Andro; Andrographis
    外观
    off-white powder
    可溶性/溶解性
    DMSO : 35.1 mg/mL (100 mM)
    生物活性
    靶点
    P50
    In vitro(体外研究)
    Andrographolide (AP) concentration-dependently suppresses receptor activator of nuclear factor kappa B ligand (RANKL)-mediated osteoclast differentiation and bone resorption in vitro and reduces the expression of osteoclast-specific markers. Andrographolide attenuates inflammation by inhibition of TNFα-induced NF-κB activation through covalent modification of reduced Cys62 of p50, without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide also inhibits the ERK/MAPK signalling pathway without affecting p38 or JNK signalling. Andrographolide inhibits osteoclast differentiation of RAW 264.7 cells in a concentration-dependent manner. Andrographolide suppresses osteoclast formation in a concentration-dependent manner without any obvious cytotoxic effects, in both BMMs and RAW 264.7 cells. Andrographolide treatment substantially reduces the area of bone resorption. Only approximately 30% of the bone resorption observed in the control group is achieved after treatment with 2.5 μM Andrographolide. Osteoclastic bone resorption is almost completely inhibited after treatment with 10 μM Andrographolide.
    In vivo(体内研究)
    Treatment with Andrographolide (5 or 30 mg/kg) reduces the extent of bone loss induced by LPS. Moreover, Andrographolide slightly increases the BMD and cortex thickness compared to LPS treatment. Histological examination confirms the protective effects of Andrographolide on LPS-induced bone loss. LPS injection leads to inflammatory bone erosion and increased numbers of TRAP-positive osteoclasts.
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