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  • β-淀粉样多肽(1-42)

    • Β淀粉样肽-42 (C端多肽); BETA-淀粉样蛋白-42,Amyloid b-Protein (1-42)
    货号: abs45128173
    CAS号: 107761-42-2
    分子式: C203H311N55O60S
    分子量: 4514.10
    产品说明书
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    货号-规格 货期 价格 数量
    abs45128173-1mg 现货 ¥2822.00
    - +
    abs45128173-5mg 现货 ¥3528.00
    - +
    abs45128173-10mg 4周 ¥5544.00
    - +
    大包装询价
    产品描述
    描述
    Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer´s disease and late Down´s syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of H-1368 corresponds to the human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42 peptide. The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer´s disease patients through fluorescence correlation spectroscopy. For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. The findings of Ryan et al. indicate that 10% ammonia disaggregates Aβ42 more efficiently than HFIP.
    来源
    合成
    序列
    H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
    纯度
    95%
    储存/保存方法
    -20 °C,避光,干燥,有效期1年。
    基本信息
    别名
    Β淀粉样肽-42 (C端多肽); BETA-淀粉样蛋白-42
    外观
    white Lyophilized powder
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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