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  • Ethambutol hydrochloride
    • 乙胺丁醇二盐酸盐;Emb dihydrochloride
    货号: abs813635
    CAS号: 1070-11-7
    分子式: C10H24N2O2.2HCl
    分子量: 277.23
    产品说明书
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    货号-规格 货期 价格 数量
    abs813635-20mg 1-2周 ¥485.00
    - +
    abs813635-50mg 1-2周 ¥662.00
    - +
    abs813635-100mg 1-2周 ¥827.00
    - +
    abs813635-200mg 1-2周 ¥1103.00
    - +
    大包装询价
    产品描述
    描述

    Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

    纯度
    >98%
    储存/保存方法
    -20°C 冷藏长期储存,常温运输及临时存放
    基本信息
    别名
    乙胺丁醇二盐酸盐;Emb dihydrochloride
    外观
    白色结晶性粉末
    可溶性/溶解性
    DMSO :52 mg/mL (187.6 mM)

    Water :51 mg/mL (184 mM)
    生物活性
    In vitro(体外研究)
    Ethambutol directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutants. Ethambutol is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol. Ethambutol is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro. Ethambutol is efficient on treatment of mycobacterial-infected macrophages. When M. tuberculosis infected macrophages are treated with 6 μg/mL Ethambutol, the log CFUs following treatment for 3 days is 4.17, while value in control group is 4.8. The MICs for M. avium (MTCC 1723) and M. smegmatis (MTCC 6) are 15 μg/mL and 0.18 μg/mL, respectively.
    In vivo(体内研究)
    Ethambutol is efficient in animal model. 100 mg/kg Ethambutol given orally 15 days post i.v. infection 1 ×/week for 5 weeks, induces a lower log CFU compared with untreatment (4.59 vs 5.07).
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