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Zoledronic acid

唑来膦酸;Zoledronate;CGP 42446; CGP42446A;ZOL 446

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货号 abs813447
规格 价格
¥510
库存状态:1-2周
¥827
库存状态:1-2周
¥1496
库存状态:1-2周
¥2063
库存状态:1-2周

数量:

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概述
描述

Zoledronic Acid 是一种有效的含氮双膦酸盐,抑制人胎儿成骨细胞(hFOB)增殖,IC50为40 μM。

别名 唑来膦酸;Zoledronate;CGP 42446; CGP42446A;ZOL 446
靶点 Rho
性能
外观 白色结晶粉末
保存方法 store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
纯度 >98%
分子量 272.09
分子结构式
化学式 C5H10N2O7P2
溶解性 1.1eq. NaOH :13.6 mg/mL (50 mM)
Water :0.7 mg/mL (2.5 mM)
CAS号 118072-93-8
生物活性
In vitro Zoledronic acid (10 µM and 100 µM) causes a significant reduction in the proportions of MCF-7 cells (49.54% and 23.55% of control, respectively) (P Zoledronic acid enhances OPG gene expression and protein secretion by human osteoblasts (hOB) in a dose-dependent fashion with a maximum effect at 10 nM after 72 hours, consistent with the higher biological potency of Zoledronic acid. Zoledronic acid prevents the inhibitory effects of the glucocorticoid dexamethasone on OPG mRNA and protein production in human osteoblasts. Zoledronic acid induces type I collagen secretion and alkaline phosphatase activity by 2- and 4-fold, respectively, in human osteoblasts.
In vivo Zoledronic acid (120 mg/kg, s.c.) prevents the formation of lesions, prevents cancellous bone loss and loss of bone mineral density, and reduces osteoclast perimeter in 5T2MM-bearing mice. Zoledronic acid (120 mg/kg, s.c.) also decreases paraprotein concentration, decreases tumor burden, and reduces angiogenesis in 5T2MM-bearing mice.