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Ac-DEVD-CHO

Caspase-3 Inhibitor I;N-Ac-Asp-Glu-Val-Asp-CHO;Acetyl-aspartyl-glutamyl-valyl-aspartal

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货号 abs811858
规格 价格
¥2695
库存状态:1-2周

数量:

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概述
描述

Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor.

别名 Caspase-3 Inhibitor I;N-Ac-Asp-Glu-Val-Asp-CHO;Acetyl-aspartyl-glutamyl-valyl-aspartal
靶点 Caspase-3;caspase-8;caspase-7;caspase-10 ;Caspase-1
性能
外观 white powder
保存方法 store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
纯度 >98%
分子量 502.5
分子结构式
化学式 C20H30N4O11
溶解性 H2O : ≥ 50 mg/mL (99.51 mM)mL
CAS号 169332-60-9
生物活性
In vitro Ac-DEVD-CHO is a potent inhibitor of caspase-3 (Ki = 230 pM). In contrast, caspase-2 cleaves the tetrapeptide substrate poorly and is only weakly inhibited by this aldehyde (Ki = 1.7 μM). Group III caspases are broadly inhibited by Ac-DEVD-CHO with Ki values ranging from 1 to 300 nM. Inhibition of caspase-3 by Ac-DEVD-CHO in isolated working-heart rat model significantly improves post-ischemic contractile recovery of stunned myocardium, even when given after the onset of ischemia. The mechanism(s) of protection by Ac-DEVD-CHO appear to be independent of apoptosis. Troponin I cleavage was not inhibited by Ac-DEVD-CHO.
In vivo Ac-DEVD-CHO administered at the time of MI results in a 61% reduction in activated caspase-3 expression in cardiomyocytes (p. Ac-DEVD-CHO suppressed and/or delayed the progression of photoreceptor cell damage in rats and delays disease progression in rd gene-carring mice, which normally develop retinal degeneration early in life.