货号: abs821257
货号-规格 | 货期 | 价格 | 数量 |
abs821257-1mg | 4周 | ¥25666.00 | - + |
abs821257-5mg | 4周 | ¥64033.00 | - + |

产品描述 | |
描述 | ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki of 13±1.7 nM. |
储存/保存方法 | store at -20℃ for one year(Powder) |
基本信息 | |
可溶性/溶解性 | DMSO* |
生物活性 | |
In vitro(体外研究) | TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321. |
In vivo(体内研究) | TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321. |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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