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  • ZD8321
    货号: abs821257
    CAS号: 182073-77-4
    分子式: C18H28F3N3O5
    分子量: 423.43
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs821257-1mg 4周 ¥25666.00
    - +
    abs821257-5mg 4周 ¥64033.00
    - +
    大包装询价
    产品描述
    描述
    ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki of 13±1.7 nM.
    储存/保存方法
    store at -20℃ for one year(Powder)
    基本信息
    可溶性/溶解性
    DMSO*
    生物活性
    In vitro(体外研究)
    TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321.
    In vivo(体内研究)
    TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321.
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