Zalcitabine
- 扎西他滨；2',3'-二脱氧胞苷；双去氧胞嘧啶核酸, 2',3'-Dideoxycytidine；ddC；Dideoxycytidine
货号： abs811894
| 货号-规格 | 货期 | 价格 | 数量 |
| abs811894-100mg | 现货 | ￥355.00 | - + |
| abs811894-200mg | 现货 | ￥585.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | Zalcitabine(Dideoxycytidine;ddC; 2',3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain. | |
| 纯度 | ≥98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | 扎西他滨；2',3'-二脱氧胞苷；双去氧胞嘧啶核酸; 2',3'-Dideoxycytidine；ddC；Dideoxycytidine | |
| 外观 | White crystalline powder | |
| 可溶性/溶解性 | DMSO : 62.5 mg/mL (295.90 mM; Need ultrasonic) | |
| 生物活性 | ||
| 靶点 | HIV reverse transcriptase | |
| In vitro(体外研究) | Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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