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  • YM-58483 (BTP2)
  • YM58483;YM 58483;BTP2
  • 货号: abs812894
    CAS号: 223499-30-7
    分子式: C15H9F6N5OS
    分子量: 421.32
    产品说明书
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    货号-规格 货期 价格 数量
    abs812894-1mg 现货 ¥364.00
    - +
    abs812894-5mg 现货 ¥918.00
    - +
    abs812894-10mg 现货 ¥1781.00
    - +
    abs812894-50mg 现货 ¥7046.00
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    大包装询价
    产品描述
    描述

     YM-58483/BTP2是钙池调控钙离子进入(SOCE)的阻滞剂,参与调解不可兴奋细胞如淋巴细胞的激活。

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
    基本信息
    别名
    YM58483;YM 58483;BTP2
    外观
    powder
    可溶性/溶解性
    DMSO : 78 mg/mL (185.1 mM)
    Ethanol : 78 mg/mL (185.1 mM)
    生物活性
    靶点
    SOCE
    In vitro(体外研究)
    YM-58483 (also known as BTP2) is a selective SOCE blocker that inhibits anti-CD3 antibody-induced sustained Ca2+ influx in Jurkat T cells. YM-58483 does not cross-react with voltage-operated Ca2+entry, K+ channels, or Cl− channels. It suppresses the CRAC, TRPC3, and TRPC5 channels, and also facilitates the TRPM4 channel. YM-58483 suppresses cytokine production (IL-2, IL-4, IL-5, IFN-γ, etc.) and proliferation in T cells in vitro. YM-58483 inhibits the spleen cell proliferation associated with MLR by suppressing NF-AT activation via sustained influx of extracellular Ca2+. YM-58483 potently inhibits IL-2 production and NF-AT-driven promoter activity, but not AP-1-driven promoter activity in Jurkat cells.
    In vivo(体内研究)
    YM-58483 exhibits inhibitory effects on several types of allergic asthma models, such as airway hyperresponsiveness, early and late bronchoconstriction, and antigen-induced airway eosinophilia, with the reduction of IL-4 and leukotriene levels in the airways of rats and guinea pigs. YM-58483 also inhibits the anti-host CTL response, donor T cell expansion, and IFN-γ production in GVHD mice. YM-58483 selectively inhibits storeoperated Ca2+ influx, it does not affect baseline intracellular Ca2+ levels. YM-58483 caused no apparent change in general activity in mice at doses up to 30 mg/kg, p.o.
    参考文献
    参考文献
    [1]. Qi Z, et al. Cell Mol Neurobiol. 2016 Oct;36(7):1035-43.
    [2]. Ohga K, et al. Int Immunopharmacol. 2008 Dec 20;8(13-14):1787-92.
    [3]. Yoshino T, et al. Eur J Pharmacol. 2007 Apr 10;560(2-3):225-33.
    [4]. Ishikawa J, et al. J Immunol. 2003 May 1;170(9):4441-9.
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