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  • Y06036

    货号: abs821270
    CAS号: 1832671-96-1
    分子式: C16H15BrN2O5S
    分子量: 427.27
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    货号-规格 货期 价格 数量
    abs821270-5mg 1-2周 ¥450.00
    - +
    abs821270-10mg 1-2周 ¥750.00
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    大包装询价
    产品描述
    描述
    Y06036 is a potent and selective BET inhibitor, which binds to the BRD4(1) bromodomain with Kd value of 82 nM. Antitumor activity.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO : 130 mg/mL (304.26 mM; Need ultrasonic)
    生物活性
    In vitro(体外研究)
    Y06036 (0.001-100 nM, 96 hours for LNCaP, C4-2B, and 22Rv1 cells; 144 hours for VCaP cells) exhibits low micromolar or nanomolar potencies (IC50: 0.29-2.6 μΜ) in the four androgen receptor (AR)-positive prostate cancer cell lines LNCaP, C4-2B, 22Rv1, and VCaP. Treatment of 22Rv1 cells with Y06036 (1, 2, 4, 8, and 16 μM, 48 hours) results in significant down-regulation of both full-length (AR-fl) and AR variants levels.Cell Viability AssayCell Line:LNCaP, C4-2B, 22Rv1, and VCaP prostate cancer cells Concentration:0.001-100 μMIncubation Time:96 hours for LNCaP, C4-2B, and 22Rv1; 144 hours for VCaPResult:Inhibited LNCaP, C4-2B, 22Rv1, and VCaP cells with IC50s of 1.06, 2.62, 1.50, 0.63 μM, respectively.
    In vivo(体内研究)
    Y06036 (0.001-100 nM, 96 hours for LNCaP, C4-2B, and 22Rv1 cells; 144 hours for VCaP cells) exhibits low micromolar or nanomolar potencies (IC50: 0.29-2.6 μΜ) in the four androgen receptor (AR)-positive prostate cancer cell lines LNCaP, C4-2B, 22Rv1, and VCaP. Treatment of 22Rv1 cells with Y06036 (1, 2, 4, 8, and 16 μM, 48 hours) results in significant down-regulation of both full-length (AR-fl) and AR variants levels.Cell Viability AssayCell Line:LNCaP, C4-2B, 22Rv1, and VCaP prostate cancer cells Concentration:0.001-100 μMIncubation Time:96 hours for LNCaP, C4-2B, and 22Rv1; 144 hours for VCaPResult:Inhibited LNCaP, C4-2B, 22Rv1, and VCaP cells with IC50s of 1.06, 2.62, 1.50, 0.63 μM, respectively.
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    • 实验方法 实验条件
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