Y06036
货号: abs821270
货号-规格 | 货期 | 价格 | 数量 |
abs821270-5mg | 1-2周 | ¥450.00 | - + |
abs821270-10mg | 1-2周 | ¥750.00 | - + |

产品描述 | ||
描述 | Y06036 is a potent and selective BET inhibitor, which binds to the BRD4(1) bromodomain with Kd value of 82 nM. Antitumor activity. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
可溶性/溶解性 | DMSO : 130 mg/mL (304.26 mM; Need ultrasonic) | |
生物活性 | ||
In vitro(体外研究) | Y06036 (0.001-100 nM, 96 hours for LNCaP, C4-2B, and 22Rv1 cells; 144 hours for VCaP cells) exhibits low micromolar or nanomolar potencies (IC50: 0.29-2.6 μΜ) in the four androgen receptor (AR)-positive prostate cancer cell lines LNCaP, C4-2B, 22Rv1, and VCaP. Treatment of 22Rv1 cells with Y06036 (1, 2, 4, 8, and 16 μM, 48 hours) results in significant down-regulation of both full-length (AR-fl) and AR variants levels.Cell Viability AssayCell Line:LNCaP, C4-2B, 22Rv1, and VCaP prostate cancer cells Concentration:0.001-100 μMIncubation Time:96 hours for LNCaP, C4-2B, and 22Rv1; 144 hours for VCaPResult:Inhibited LNCaP, C4-2B, 22Rv1, and VCaP cells with IC50s of 1.06, 2.62, 1.50, 0.63 μM, respectively. | |
In vivo(体内研究) | Y06036 (0.001-100 nM, 96 hours for LNCaP, C4-2B, and 22Rv1 cells; 144 hours for VCaP cells) exhibits low micromolar or nanomolar potencies (IC50: 0.29-2.6 μΜ) in the four androgen receptor (AR)-positive prostate cancer cell lines LNCaP, C4-2B, 22Rv1, and VCaP. Treatment of 22Rv1 cells with Y06036 (1, 2, 4, 8, and 16 μM, 48 hours) results in significant down-regulation of both full-length (AR-fl) and AR variants levels.Cell Viability AssayCell Line:LNCaP, C4-2B, 22Rv1, and VCaP prostate cancer cells Concentration:0.001-100 μMIncubation Time:96 hours for LNCaP, C4-2B, and 22Rv1; 144 hours for VCaPResult:Inhibited LNCaP, C4-2B, 22Rv1, and VCaP cells with IC50s of 1.06, 2.62, 1.50, 0.63 μM, respectively. | |
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