VCMMAE
货号： abs812281
| 货号-规格 | 货期 | 价格 | 数量 |
| abs812281-5mg | 1-2周 | ￥5458.00 | - + |
| abs812281-10mg | 1-2周 | ￥8435.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | VcMMAE是抗体偶联药物（ADC）中的抗有丝分裂剂，由一甲基阿里他汀E（MMAE）与二肽缬氨酸-瓜氨酸（Vc）交联而成。 | |
| 纯度 | 98% min | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 可溶性/溶解性 | DMSO: ≥ 54 mg/mL | |
| 生物活性 | ||
| 靶点 | Antibody-drug Conjugate | |
| In vitro(体外研究) | Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells. MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. Radiosensitization is evidenced by decreased clonogenic survival and increased DNA double strand breaks in irradiated cells. | |
| In vivo(体内研究) | Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolonged tumor regression in xenograft models. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
共 0 张，还能上传 8 张 提交
- 提示： 尊敬的客户您好，如果您对我们的产品有什么疑问或想要了解的，可以点击“我要咨询”按钮填写您的疑问。
提交不成功？请联系info@absin.cn。
Certificate of Analysis(COA)
促销资讯 更多
订购信息
您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商，请从以下的下拉列表中选择。
危险品化学品经营许可证(不带存储)
营业执照(三证合一)