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  • VCMMAE

    货号: abs812281
    CAS号: 646502-53-6
    分子式: C68H105N11O15
    分子量: 1316.63
    产品说明书
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    货号-规格 货期 价格 数量
    abs812281-5mg 1-2周 ¥5458.00
    - +
    abs812281-10mg 1-2周 ¥8435.00
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    大包装询价
    产品描述
    描述

    VcMMAE是抗体偶联药物(ADC)中的抗有丝分裂剂,由一甲基阿里他汀E(MMAE)与二肽缬氨酸-瓜氨酸(Vc)交联而成。

    纯度
    98% min
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO: ≥ 54 mg/mL
    生物活性
    靶点
    Antibody-drug Conjugate
    In vitro(体外研究)
    Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells. MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. Radiosensitization is evidenced by decreased clonogenic survival and increased DNA double strand breaks in irradiated cells.
    In vivo(体内研究)
    Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolonged tumor regression in xenograft models.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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