VCMMAE
货号: abs812281
货号-规格 | 货期 | 价格 | 数量 |
abs812281-5mg | 1-2周 | ¥5458.00 | - + |
abs812281-10mg | 1-2周 | ¥8435.00 | - + |

产品描述 | ||
描述 | VcMMAE是抗体偶联药物(ADC)中的抗有丝分裂剂,由一甲基阿里他汀E(MMAE)与二肽缬氨酸-瓜氨酸(Vc)交联而成。 | |
纯度 | 98% min | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
可溶性/溶解性 | DMSO: ≥ 54 mg/mL | |
生物活性 | ||
靶点 | Antibody-drug Conjugate | |
In vitro(体外研究) | Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells. MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. Radiosensitization is evidenced by decreased clonogenic survival and increased DNA double strand breaks in irradiated cells. | |
In vivo(体内研究) | Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolonged tumor regression in xenograft models. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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