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  • Vanoxerine
    货号: abs818551
    CAS号: 67469-69-6
    分子式: C28H32F2N2O
    分子量: 450.56
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    货号-规格 货期 价格 数量
    abs818551-10mg 1-2周 ¥970.00
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    abs818551-50mg 1-2周 ¥3528.00
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    大包装询价
    产品描述
    描述
    Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).IC50 value:Target: Dopamine reuptake inhibitorAt a cellular level, vanoxerine acts to block cardiac ion channels. Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels.[14] By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine. Vanoxerine is a potentially effective treatment for cardiac arrhythmias. A significant cause of cardiac arrhythmias is reentry, an electrophysiologic event in which the proliferating signal that refuses to terminate, and endures to reexcite the heart after the refractory period.
    基本信息
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    Dopamine Transporter
    参考文献
    参考文献
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