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  • UK-5099

    • PF-1005023; UK5099; UK 5099; PF1005023; PF 1005023
    货号: abs810654
    CAS号: 56396-35-1
    分子式: C18H12N2O2
    分子量: 288.31
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810654-5mg 1-2周 ¥789.00
    - +
    abs810654-10mg 1-2周 ¥1213.00
    - +
    abs810654-50mg 1-2周 ¥4123.00
    - +
    abs810654-100mg 1-2周 ¥6549.00
    - +
    大包装询价
    产品描述
    描述
    UK-5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    PF-1005023; UK5099; UK 5099; PF1005023; PF 1005023
    外观
    yellow to tan powder
    可溶性/溶解性
    DMSO : ≥ 50 mg/mL (173.43 mM)
    生物活性
    靶点
    mitochondrial pyruvate carrier
    In vitro(体外研究)
    UK-5099 covalently binds to Mpc and blocks pyruvate transport. UK-5099 enhances aerobic glycolysis and decreases mitochondrial oxidative phosphorylation in LnCap cell in vitro, which is accompanied by increasing proportion of side population (SP) fraction, higher level of stemness markers expression and exhibiting high resistance to chemotherapy. UK5099 enhances stem-like phenotype of prostatic cancer cell through metabolic shift from oxidative phosphorylation to aerobic glycolysis. UK-5099 suppresses proliferation and arrested LnCap cell cycle at G1/G0.
    In vivo(体内研究)
    UK-5099 slows the growth of patient-derived xenograft (PDX) tumors in mice without severe loss of animal body weight.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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