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  • Tripelennamine hydrochloride
    • 盐酸曲吡那敏;盐酸吡苄明;Pyribenzamine hydrochloride
    货号: abs813871
    CAS号: 154-69-8
    分子式: C16H21N3.HCl
    分子量: 291.82
    产品说明书
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    货号-规格 货期 价格 数量
    abs813871-25mg 1-2周 ¥432.00
    - +
    abs813871-50mg 1-2周 ¥775.00
    - +
    abs813871-100mg 1-2周 ¥849.00
    - +
    abs813871-200mg 1-2周 ¥1211.00
    - +
    大包装询价
    产品描述
    描述

    Tripelennamine HCl是一种广泛使用的组胺1拮抗剂(H1拮抗剂),抑制PhIP糖脂化,IC50

    纯度
    >98%
    储存/保存方法
    -20°C
    基本信息
    别名
    盐酸曲吡那敏;盐酸吡苄明;Pyribenzamine hydrochloride
    外观
    白色结晶性粉末
    可溶性/溶解性
    Ethanol :1 mg/mL (3.42 mM)

    DMSO :2 mg/mL (6.85 mM)

    Water :53 mg/mL (181.6 mM)
    生物活性
    靶点
    H1 receptor
    In vitro(体外研究)
    Tripelennamine is a substrate for a tertiary amine UDP-glucuronosyltransferases which catalyzes the formation of quaternary ammonium-linked glucuronides. Tripelennamine inhibits the glucuronidation of 2-amino-1-methyl-6-phenylimidazo pyridine (PhIP) by a mixture of competitive and noncompetitive inhibition in both human and rabbit liver microsomes. Vibrations of the aminopyridine chromophore in Tripelennamine at neutral pH, where the aminoalkyl chain is protonated, are modified when compared to the vibrational pattern recorded for a fully neutral molecule in alkaline solution.
    In vivo(体内研究)
    Tripelennamine HCl (i.v.) causes central nervous system (CNS) excitement in standing horses, and the horses became very alert, agitated, and uncomfortable, as indicated by their raising the head and tightening the neck muscles, excessive rapid movements of eyes and ears, biting, snorting, briskly swishing the tail, and stomping and pawing with front feet. Accordingly, hemoglobin concentration of standing horses increase significantly after Tripelennamine HCl treatment. Tripelennamine HCl (i.v.) significantly increases mixed venous blood O2 tension and hemoglobin-O2 saturation in standing horse, as well as arterial and mixed-venous blood O2 contents, but the arterial-to-mixed-venous O2 content gradient of standing horses is not significantly affected. Tripelennamine HCl (0.5 mg/kg i.v.) administrated both in horses and camels results in the terminal elimination half-lives of 2.39 and 2.08 hours, total body clearances of 0.97 and 0.84 L/h/kg. The volumes of distribution at steady state are 2.87 and 1.69 L/kg, the volumes of the central compartment of the two compartment pharmacokinetic model are 1.75 and 1.06 L/kg.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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