TP0903
货号: abs817386
货号-规格 | 货期 | 价格 | 数量 |
abs817386-5mg | 1-2周 | ¥1031.00 | - + |
abs817386-25mg | 1-2周 | ¥4409.00 | - + |
abs817386-100mg | 1-2周 | ¥10066.00 | - + |

产品描述 | ||
描述 | TP-0903 is a potent and selective Axl kinase inhibitor with IC50 of 27 nM. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
可溶性/溶解性 | 10 mM in DMSO | |
生物活性 | ||
靶点 | Axl | |
In vitro(体外研究) | In pancreatic cancer cells (PSN-1), TP-0903 shows strong antiproliferative activity with IC50 of 6 M. TP-0903 also induces strong G2/M arrest by potently inhibiting Aurora A and B. In CLL B cells from all the patients with CLL, TP-0903 causes a dose-dependent induction of massive apoptosis by targeting phosphorylated Axl, and overcomes CLL BMSC-mediated protection of CLL B cells from apoptosis. | |
In vivo(体内研究) | In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. | |
参考文献 | ||
参考文献 | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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