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  • TOS-ARG-OME HCl
    • TOS-ARG-OME hydrochloride;NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐
    货号: abs817354
    CAS号: 1784-03-8
    分子式: C14H23ClN4O4S
    分子量: 378.87
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs817354-50mg 1-2周 ¥386.00
    - +
    abs817354-100mg 1-2周 ¥662.00
    - +
    abs817354-500mg 1-2周 ¥1103.00
    - +
    大包装询价
    产品描述
    描述

    TOS-ARG-OME hydrochloride is a kind od amino acid derivatives.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    TOS-ARG-OME hydrochloride;NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐
    外观
    白色粉末
    可溶性/溶解性
    DMSO > 10 mM
    生物活性
    靶点
    APC
    In vitro(体外研究)
    TAME shows inhibitory effect on APC activation when added to mitotic Xenopus extract. TAME (1-200 μM) inhibits Cdc20 association with mitotic APC and also inhibits Cdh1 association with interphase APC. TAME significantly inhibits crosslinking of the IR peptide to Cdc27 and Cdc16 but only slightly reduces crosslinking to Cdc23 and Apc7 at 20 µM; TAME strongly inhibits crosslinking to all APC subunits at 200 µM. TAME also inhibits binding of wild type Cdc20 to the APC, but not binding of a ΔIR mutant. TAME (200 μM) induces Cdc20 dissociation from the APC in mitotic Xenopus extract calls for APC-dependent ubiquitination. TAME induces Cdc20 dissociation from the APC by promoting Cdc20 ubiquitination, but the dissociation can be suppresses by Cyclin B1. TAME terminates cyclin B1 ubiquitination prematurely. TAME interacts with ATP by β and γ phosphate and the adenine ring of ATP. TAME in combination with the Mg(II) ion accelerates the ATP hydrolysis process.
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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