Torsemide
- 托拉塞米;Torasemide
货号: abs813960
货号-规格 | 货期 | 价格 | 数量 |
abs813960-10mg | 1-2周 | ¥463.00 | - + |
abs813960-50mg | 1-2周 | ¥659.00 | - + |
abs813960-100mg | 1-2周 | ¥1188.00 | - + |

产品描述 | ||
描述 | Torsemide (Demadex) is a pyridine-sulfonyl urea type loop diuretic with an IC50 of 2.7 ?0.17 uM. It was mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 托拉塞米;Torasemide | |
外观 | 白色或类白色粉末 | |
可溶性/溶解性 | DMSO :1 mg/mL (2.87 mM) | |
生物活性 | ||
靶点 | Cl- channel | |
In vitro(体外研究) | Torsemide inhibits aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. Torsemide's primary site of action is the thick ascending loop of Henle in the nephron, where it promotes excretion of sodium, water, and chloride via interaction with the Na+, K+, 2Cl− cotransporter. Torsemide interferes with the secretion of, and receptor ligand binding of, the mineralocorticoid aldosterone in a dose-dependent manner. | |
In vivo(体内研究) | Torsemide results in elevated levels of circulating angiotensin II and aldosterone (supportive of interference with aldosterone at the receptor level) in dogs with experimental mitral regurgitation whereas furosemide results in elevated levels of angiotensin II, only. Torsemide increases the BUN and plasma creatinine concentrations in rats, compared with the baseline value. Torsemide immediately increases urine volume significantly. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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