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  • Tetrahydropalmatine
    • 延胡索乙素;消旋延胡索乙素;罗通定;DL-Tetrahydropalmatine
    货号: abs813174
    CAS号: 2934-97-6
    分子式: C21H25NO4
    分子量: 355.42
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    货号-规格 货期 价格 数量
    abs813174-10mg 1-2周 ¥607.00
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    abs813174-50mg 1-2周 ¥938.00
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    大包装询价
    产品描述
    描述

    Tetrahydropalmatine, an active component isolated from corydalis, acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

    来源
    延胡索
    纯度
    ≥98%
    储存/保存方法
    Store at -20°C
    产品用途
    用于含量测定、鉴别、药理实验、活性筛选等
    基本信息
    别名
    延胡索乙素;消旋延胡索乙素;罗通定;DL-Tetrahydropalmatine
    外观
    白色粉末
    可溶性/溶解性
    DMSO : 6.67 mg/mL (18.77 mM; Need ultrasonic)
    生物活性
    靶点
    Dopamine
    In vivo(体内研究)
    Tetrahydropalmatine (THP), an active component isolated from corydalis (a Chinese herbal medicine), possesses analgesic effects. Picrotoxin treatment alone has a significant effect on the following activity measure: there is an increase in horizontal motion time (HMT), vertical motion time (VMT), clockwise turnings (CT), anticlockwise turning (ACT) and a decrease in freezing time (FT). Tetrahydropalmatine treatment alone causes a decrease in HMT, VMT and total distance traveled (TDT), but an increase in FT. Pretreatment of rats with an i.p. dose of 10 mg/kg or 15 mg/kg of Tetrahydropalmatine significantly attenuates the Picrotoxin-induced enhancement in HMT, VMT, CT, ACT and TDT, as well as reduction in FT. Another 48 rats under urethane anesthesia are randomly divided into six groups, each of eight rats. The s.c. injection of Picrotoxin causes an increase in amygdaloid release of dopamine (DA), while i.p. injection of Tetrahydropalmatine at 10 mg/kg has an insignificant effect on amygdaloid release of DA. Again, the Picrotoxin-induced increase in amygdaloid release of DA is significantly attenuated by pretreatment with Tetrahydropalmatine. The Picrotoxin-induced augmented amygdaloid release of DA is almost completely abolished by pretreatment with Tetrahydropalmatine 30 min before s.c. injection of Picrotoxin.
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