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  • (±)-Tazifylline
    • (±)-他齐茶碱
    货号: abs822732
    CAS号: 79712-55-3
    分子式: C23H32N6O3S
    分子量: 472.60
    产品说明书
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    货号-规格 货期 价格 数量
    abs822732-1mg 缺货 询价
    abs822732-5mg 缺货 询价
    大包装询价
    产品描述
    描述
    (±)-Tazifylline is a potent, selective and long-acting histamine H1 receptor antagonist.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    (±)-他齐茶碱
    可溶性/溶解性
    DMSO*
    生物活性
    靶点
    H1-receptor
    In vitro(体外研究)
    Tazifylline potently inhibits contractions evoked by stimulation of histamine H1-receptors in isolated guinea pig ilea and exhibits high affinity for these receptors in radioligand binding studies in vitro Tazifylline has much lower affinity for histamine H2-receptors, alpha- and beta-adrenoceptors, 5-hydroxytryptamine and muscarinic receptor subtypes. Tazifylline poorly inhibits the release of histamine from rat peritoneal mast cells.
    In vivo(体内研究)
    In rats, guinea pigs and dogs the antihistaminic effect of Tazifylline is rapid in onset and long-lived. In anesthetized guinea pigs, Tazifylline markedly inhibits histamine-induced bronchoconstriction and protects conscious animals from the lethal effect of large doses of the amine. In conscious rats, Tazifylline is more potent in reducing the inflammatory effects of intradermal histamine than that evoked by anaphylactic reaction. In conscious dogs, orally administered Tazifylline inhibits histamine-induced skin inflammation for long periods of time and in anesthetized animals attenuated that portion of the histamine-evoked hypotension attributable to stimulation of H1-receptors. Large oral doses of Tazifylline does not reduce spontaneous locomotor activity in mice, nor do they produce overt symptoms of behavioral depression in conscious rats.
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    • 实验方法 实验条件
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