Tasimelteon
- 他司美琼;BMS-214778;VEC-162
货号: abs813161
货号-规格 | 货期 | 价格 | 数量 |
abs813161-5mg | 1-2周 | ¥460.00 | - + |
abs813161-10mg | 1-2周 | ¥828.00 | - + |
abs813161-50mg | 1-2周 | ¥2898.00 | - + |
abs813161-100mg | 1-2周 | ¥4671.00 | - + |

产品描述 | ||
描述 | Tasimelteon is a melatonin MT1 and MT2 receptor agonist. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 他司美琼;BMS-214778;VEC-162 | |
可溶性/溶解性 | DMSO ≥33 mg/mL | |
生物活性 | ||
靶点 | MT2 receptor ,MT1 receptor | |
In vitro(体外研究) | Tasimelteon is a circadian regulator that resets the master clock in the suprachiasmatic nuclei of the hypothalamus by binding to both melatonin MT1 and MT2 receptors making it a dual melatonin receptor agonist. The affinity of tasimelteon for the MT2 receptor is 4-fold higher than its affinity for the MT1 receptor. | |
In vivo(体内研究) | In rats and monkeys, the half-life of tasimelteon was approximately 2 h which is longer than the half-life of melatonin. Tasimelteon has a mean absolute bioavailability of approximately 38.3%. The higher oral-to-IV exposure ratios and decrease in the metabolite-to-parent ratios after IV administration for tasimelteon's metabolites indicate that although tasimelteon is subject to first-pass metabolism, a substantial fraction of its metabolism occurs post- rather than presystemically. Both oral and IV tasimelteon were well tolerated. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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