TAME
货号: abs811021
货号-规格 | 货期 | 价格 | 数量 |
abs811021-5mg | 4周 | ¥463.00 | - + |
abs811021-10mg | 4周 | ¥631.00 | - + |
abs811021-50mg | 4周 | ¥1189.00 | - + |
abs811021-100mg | 4周 | ¥2001.00 | - + |

产品描述 | ||
描述 | TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
可溶性/溶解性 | DMSO 69 mg/mL (201.51 mM) Water 69 mg/mL (201.51 mM) Ethanol 3 mg/mL (8.76 mM) | |
生物活性 | ||
靶点 | APC | |
In vitro(体外研究) | TAME inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 µM. TAME at concentration of 1-200 μM arrests interphase extract treated with recombinant cyclin B1/Cdc2 complex in mitosis, with stable cyclin B1 and phosphorylated Cdc27. TAME at concentration of 200 μM dramaticly inhibits the ubiquitin ligase activity of the Anaphase-Promoting Complex (APC), accompanied by reduced binding of Cdh1 to APC. TAME addition to interphase extract reduces Cdc20 association with the APC in a dose-dependent manner partly by binding directly to APC, and the contribution motif is the C-terminal isoleucine-arginine (IR) tail on APC. TAME is hydrolysed by trypsin with Km of 0.328 mM. TAME accelerates the ATP hydrolysis process about 12-fold. TAME interacts with β and γ phosphate and the adenine ring of ATP by the guanidinium group and the aromatic ring. TAME at concentration of 50 mM inhibits nutrient-induced germination and pressure-induced germination at 600 MPa in Bacillus subtilis. TAME induces a concentration dependent contractile response on ileal strips with EC50 of 4.3 x 103 M. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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