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  • TAME

    货号: abs811021
    CAS号: 901-47-3
    分子式: C14H22N4O4S
    分子量: 324.41
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs811021-5mg 4周 ¥463.00
    - +
    abs811021-10mg 4周 ¥631.00
    - +
    abs811021-50mg 4周 ¥1189.00
    - +
    abs811021-100mg 4周 ¥2001.00
    - +
    大包装询价
    产品描述
    描述

    TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO 69 mg/mL (201.51 mM)

    Water 69 mg/mL (201.51 mM)

    Ethanol 3 mg/mL (8.76 mM)
    生物活性
    靶点
    APC
    In vitro(体外研究)
    TAME inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 µM. TAME at concentration of 1-200 μM arrests interphase extract treated with recombinant cyclin B1/Cdc2 complex in mitosis, with stable cyclin B1 and phosphorylated Cdc27. TAME at concentration of 200 μM dramaticly inhibits the ubiquitin ligase activity of the Anaphase-Promoting Complex (APC), accompanied by reduced binding of Cdh1 to APC. TAME addition to interphase extract reduces Cdc20 association with the APC in a dose-dependent manner partly by binding directly to APC, and the contribution motif is the C-terminal isoleucine-arginine (IR) tail on APC. TAME is hydrolysed by trypsin with Km of 0.328 mM. TAME accelerates the ATP hydrolysis process about 12-fold. TAME interacts with β and γ phosphate and the adenine ring of ATP by the guanidinium group and the aromatic ring. TAME at concentration of 50 mM inhibits nutrient-induced germination and pressure-induced germination at 600 MPa in Bacillus subtilis. TAME induces a concentration dependent contractile response on ileal strips with EC50 of 4.3 x 103 M.
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