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  • TAK-242 (Resatorvid)

    • 瑞沙托维;Resatorvid; TAK242; TAK 242
    货号: abs814050
    CAS号: 243984-11-4
    分子式: C15H17ClFNO4S
    分子量: 361.82
    产品说明书
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    货号-规格 货期 价格 数量
    abs814050-5mg 现货 ¥1323.00
    - +
    abs814050-10mg 现货 ¥1985.00
    - +
    abs814050-50mg 1-2周 ¥7718.00
    - +
    大包装询价
    产品描述
    描述

    TAK-242 (Resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    瑞沙托维;Resatorvid; TAK242; TAK 242
    外观
    淡黄色固体
    可溶性/溶解性
    DMSO : ≥ 360 mg/mL (994.97 mM)
    生物活性
    靶点
    TLR4
    In vitro(体外研究)
    In RAW264.7 cells and mouse peritoneal macrophages, Resatorvid (TAK-242) suppresses lipopolysaccharide (LPS)-induced production of NO, tumor necrosis factor-α (TNF-α), and interleukin (IL)-6, with IC50 of 1.1 to 11 nM. Resatorvid (TAK-242) also suppresses the production of these cytokines from LPS-stimulated human peripheral blood mononuclear cells (PBMCs) at IC50 values from 11 to 33 nM.
    In vivo(体内研究)
    Resatorvid (TAK-242) apparently reduces the serum anti-dsDNA levels in both genotype mice. Alternatively, IFN-γ, TNF-α, and IL-1β production is markedly inhibited by Resatorvid (TAK-242), but their concentrations are still greatly higher than those in NS-treated counterparts. Resatorvid (TAK-242) pre-stress administration prevents the accumulation of potentially deleterious inflammatory and oxidative/nitrosative mediators in the brain frontal cortex of rats. Resatorvid (TAK-242) i.v. administration at the beginning of the stress session completely blocks TLR-4 mRNA and protein upregulation after stress exposure.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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