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  • Stugeron
    • 桂利嗪
    货号: abs816950
    CAS号: 298-57-7
    分子式: C26H28N2
    分子量: 368.51
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs816950-25mg 1-2周 ¥307.00
    - +
    abs816950-50mg 1-2周 ¥549.00
    - +
    abs816950-100mg 1-2周 ¥604.00
    - +
    abs816950-200mg 1-2周 ¥1087.00
    - +
    大包装询价
    产品描述
    描述

    Cinnarizine is a drug derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker, it is also known to promote cerebral blood flow, and so is used to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    桂利嗪
    外观
    白色或类白色结晶性粉末
    可溶性/溶解性
    DMSO : 68 mg/mL (184.5 mM)
    生物活性
    靶点
    Calcium channel,Histamine receptor
    In vitro(体外研究)
    Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations and is a histamine receptor antagonists.
    In vivo(体内研究)
    Cinnarizine has anticonvulsive properties in rats and mice. It could provide a direct neuroprotective effect against the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizures. Cinnarizine induces behavioural changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in female parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolism. Its half-life is 4 hours.
    参考文献
    参考文献
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