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  • STF-083010
  • 货号: abs812827
    CAS号: 307543-71-1
    分子式: C15H11NO3S2
    分子量: 317.38
    产品说明书
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    货号-规格 货期 价格 数量
    abs812827-10mg 1-2周 ¥824.00
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    大包装询价
    产品描述
    描述

     STF-083010 is a specific IRE1α endonuclease inhibitor.

    纯度
    98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    可溶性/溶解性
    DMSO Solubility: 63 mg/mL (198.5 mM)
    生物活性
    靶点
    IRE1α endonuclease
    In vitro(体外研究)
    In RPMI 8226, MM.1S, and MM.1R MM cell lines, STF-083010 exhibits cytostatic and cytotoxic activity in a dose and time dependent manner. In MiaPaCa2, Panc0403, and SU8686 cell lines, STF-083010 inhibits XBP1 splicing and blocks IRE1α's endonuclease activity without affecting its kinase activity. In Eμ-TCL1 CLL cells, STF-083010 exhibits about 70% growth inhibition after 3 days culture. In MEC1 and MEC2 cells, STF-083010 produces 20% growth inhibition in 48 h. WaC3 cells respond to treatments with STF-083010 with gradually decreased growth.
    In vivo(体内研究)
    In human multiple myeloma (MM) xenografts model, STF-083010 (i.p., 30 mg/kg) significantly inhibits the growth of tumor.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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