Sennoside B
- 番泻苷 B
货号: abs816015
货号-规格 | 货期 | 价格 | 数量 |
abs816015-25mg | 1-2周 | ¥2134.00 | - + |

产品描述 | ||
描述 | Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation. | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 番泻苷 B | |
外观 | 黄色结晶粉末 | |
可溶性/溶解性 | DMSO :100 mg/mL (115.9 mM) Ethanol :1 mg/mL (1.15 mM) | |
生物活性 | ||
靶点 | PDGFR,PDGFR | |
In vitro(体外研究) | Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM. | |
In vivo(体内研究) | LD50: Mice 5000 mg/kg (i.g.); Rats 5000mg/kg (i.g.). | |
参考文献 | ||
参考文献 | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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