Sennoside B

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

番泻苷 B

黄色结晶粉末

DMSO ：100 mg/mL (115.9 mM)

Ethanol ：1 mg/mL (1.15 mM)

PDGFR,PDGFR

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM.

LD50: Mice 5000 mg/kg (i.g.); Rats 5000mg/kg (i.g.).

[1]?Hiraoka A, et al. Chem Pharm Bull, 1989, 37(10), 2744-2746.

[2] Chen YC, et al. Life Sci. 2009, 84(25-26), 915-922.

[3] Mengs U, et al. Pharmacology, 1988, 36(Suppl. 1), 180-187.