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  • SEA0400
    • SEA 0400, SEA-0400
    货号: abs811746
    CAS号: 223104-29-8
    分子式: C21H19F2NO3
    分子量: 371.38
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs811746-5mg 1-2周 ¥2409.00
    - +
    abs811746-10mg 1-2周 ¥3301.00
    - +
    abs811746-50mg 1-2周 ¥9504.00
    - +
    大包装询价
    产品描述
    描述

    SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger with IC50 of 5-33 nM (inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia).

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    SEA 0400, SEA-0400
    可溶性/溶解性
    DMSO: ≥ 32 mg/mL
    生物活性
    靶点
    Na(addition)_Ca2(addition) Exchanger
    In vitro(体外研究)
    SEA0400 inhibits Na+-dependent 45Ca2+ uptake in cultured neurons, astrocytes, and microglia. IC50 values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia). SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca2+-dependent manner.
    In vivo(体内研究)
    SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice.
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