SB-431542
促销商品- SB431542;SB 431542
货号: abs810481
货号-规格 | 货期 | 价格 | 数量 |
abs810481-5mg | 现货 | - + | |
abs810481-10mg | 现货 | - + | |
abs810481-50mg | 现货 | - + |

产品描述 | ||
描述 | SB-431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | SB431542;SB 431542 | |
外观 | 黄色至粉色固体 | |
可溶性/溶解性 | DMSO : 38.4 mg/mL(100 mM) Ethanol : 3.8 mg/mL(10 mM) | |
生物活性 | ||
靶点 | ALK4;ALK7;ALK5 | |
In vitro(体外研究) | SB-431542 inhibits TGF-beta1-induced fibronectin mRNA formation while displaying no measurable cytotoxicity in the 48 h XTT assay. SB-431542 (1 μM) significantly reduced the TGFβ–induced nuclear accumulation of Smad proteins. The IC50 for inhibiting TGFβ–induced nuclear fluorescence is approximately 50 nM. BMP-stimulated Smad1 nuclear fluorescence in MG63 cells was unaffected by SB-431542. the synergistic action of two inhibitors of SMAD signaling, Noggin and SB431542, is sufficient to induce rapid and complete neural conversion of >80% of hES cells under adherent culture conditions. | |
In vivo(体内研究) | SB-431542 augmented the capacity of bone marrow dendritic cells (BM-DCs) and human DCs to incorporate FITC-conjugated dextran. Intraperitoneal administration of SB-431542 initiated 3 and 7 days after the implantation of colon-26 cancer cells into the peritoneal cavity of BALB/c mice significantly induced CTL activity against colon-26. SB-431542 significantly inhibited lung metastasis from transplanted 4T1 mammary tumors in Balb/c mice. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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- Tissue‐resident CD8+T memory cells with unique properties are present in human decidua during early pregnancy
Xixi Huang, Lu Liu, Chunfang Xu, Xiandong Peng, Dajin Li, Li Wang, Meirong Du
American Journal of Reproductive Immunology. 2020 Apr 23 .
影响因子: 3.091
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