首页 产品中心
  • SB-431542

    促销商品
    • SB431542;SB 431542
    货号: abs810481
    CAS号: 301836-41-9
    分子式: C22H16N4O3
    分子量: 384.39
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810481-5mg 现货 ¥441.00 ¥397.00
    - +
    abs810481-10mg 现货 ¥633.00 ¥570.00
    - +
    abs810481-50mg 现货 ¥2756.00 ¥2480.00
    - +
    大包装询价
    产品描述
    描述

    SB-431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    SB431542;SB 431542
    外观
    黄色至粉色固体
    可溶性/溶解性

    DMSO : 38.4 mg/mL(100 mM)

    Ethanol : 3.8 mg/mL(10 mM)
    生物活性
    靶点
    ALK4;ALK7;ALK5
    In vitro(体外研究)
    SB-431542 inhibits TGF-beta1-induced fibronectin mRNA formation while displaying no measurable cytotoxicity in the 48 h XTT assay. SB-431542 (1 μM) significantly reduced the TGFβ–induced nuclear accumulation of Smad proteins. The IC50 for inhibiting TGFβ–induced nuclear fluorescence is approximately 50 nM. BMP-stimulated Smad1 nuclear fluorescence in MG63 cells was unaffected by SB-431542. the synergistic action of two inhibitors of SMAD signaling, Noggin and SB431542, is sufficient to induce rapid and complete neural conversion of >80% of hES cells under adherent culture conditions.
    In vivo(体内研究)
    SB-431542 augmented the capacity of bone marrow dendritic cells (BM-DCs) and human DCs to incorporate FITC-conjugated dextran. Intraperitoneal administration of SB-431542 initiated 3 and 7 days after the implantation of colon-26 cancer cells into the peritoneal cavity of BALB/c mice significantly induced CTL activity against colon-26. SB-431542 significantly inhibited lung metastasis from transplanted 4T1 mammary tumors in Balb/c mice.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
      0张,还能上传 8 提交
          提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要提问”按钮填写您的疑问。
          提交不成功?请联系info@absin.cn。
          我要提问

      促销资讯 更多

        订购信息
        您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
        GO
        • 0