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  • Recombinant SARS-CoV-2 Spike RBD (B.1.1.529/Omicron) protein C-6His

    • SARS-CoV-2 RBD Protein, SARS-CoV-2 Spike RBD Protein, SARS-CoV-2 S Protein RBD
    货号: abs04719
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    货号-规格 货期 价格 数量
    abs04719-1mg 1-2周 ¥20670.00
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    大包装询价
    概述
    描述
    Recombinant SARS-CoV-2 S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Arg319-Phe541 (G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H) is expressed with a 6His tag at the C-terminus. G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y and Y505H mutations were identified in the SARS-CoV-2 variant (known as Omicron/B.1.1.529 lineage) which emerged in South Africa.
    别名
    SARS-CoV-2 RBD Protein, SARS-CoV-2 Spike RBD Protein, SARS-CoV-2 S Protein RBD
    种属
    SARS-CoV-2
    来源
    Mammalian
    分子量
    26.2kDa AP Mol Mass: 32-40kDa, reducing conditions
    形态
    Supplied as a 0.2 μm filtered solution of PBS, pH 7.4
    性能
    序列
    Arg319-Phe541
    标签
    C-6His
    纯化方法
    Affinity purification chromatography
    纯度
     Greater than 95% as determined by reducing SDS-PAGE.
    内毒素水平
    Less than 1 EU per μg by the LAL method.
    标记
    unconjugated
    储存/保存方法
    6 months from date of receipt,-20℃ to -70℃ as supplied.avoid repeated freeze-thaw cycles.
    靶标
    背景说明
    The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
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