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  • SAR-100842
  • 货号: abs820321
    CAS号: 1195941-38-8
    分子式: C27H27NO5
    分子量: 445.51
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs820321-1mg 4周 ¥8012.00
    - +
    abs820321-5mg 4周 ¥15145.00
    - +
    大包装询价
    产品描述
    描述
    SAR-100842 is a lysophaphatidic acid 1 (LPA1/Edg-2) receptor inhibitor.
    纯度
    98%
    储存/保存方法
    store at -20℃ for one year(Powder)
    生物活性
    靶点
    LPA1/Edg-2 Receptor
    In vitro(体外研究)
    SAR-100842 (Compound Example 14) is an Edg-2 receptor inhibitor extracted from patent WO2009135590A1, has an IC50 of . SAR-100842 (SAR100842) is a lysophaphatidic acid receptor 1 (LPA1) inhibitor, which can be used for the treatment of systemic sclerosis and related fibrotic diseases. In LPAR1-based in vitro inhibition of LPA-stimulated Ca2+ flux in a cell based assay, SAR-100842 (SAR100842) has an IC50 of 65 nM; and shows no activity up to 10 μM on LPA2, LPA3 or LPA5 in similar calcium assays. Increasing doses of SAR-100842 do not significantly affect proliferation of either cell line over time. There is a significant decrease in the ability of cells to migrate in a wound healing assay in a dose dependent manner, 64% reduction (p.
    In vivo(体内研究)
    SAR-100842 (Compound Example 14) is an Edg-2 receptor inhibitor extracted from patent WO2009135590A1, has an IC50 of . SAR-100842 (SAR100842) is a lysophaphatidic acid receptor 1 (LPA1) inhibitor, which can be used for the treatment of systemic sclerosis and related fibrotic diseases. In LPAR1-based in vitro inhibition of LPA-stimulated Ca2+ flux in a cell based assay, SAR-100842 (SAR100842) has an IC50 of 65 nM; and shows no activity up to 10 μM on LPA2, LPA3 or LPA5 in similar calcium assays. Increasing doses of SAR-100842 do not significantly affect proliferation of either cell line over time. There is a significant decrease in the ability of cells to migrate in a wound healing assay in a dose dependent manner, 64% reduction (p.
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