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  • Sangivamycin
    • 7-Deaza-7-carbamoyladenosine
    货号: abs42027034
    CAS号: 18417-89-5
    分子式: C12H15N5O5 · xH2O
    分子量: 309.3
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    货号-规格 货期 价格 数量
    abs42027034-1mg 6-8周 ¥2525.00
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    大包装询价
    产品描述
    描述
    Sangivamycin is a cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). Sangivamycin is also a selective and potent PKC (protein kinase C) inhibitor (IC50 = 10μM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors. The phosphorylation of histone H1 protein is a mechanism by which Sangivamycin prevents the cell growth and acts as cytotoxic agent against a variety of human cancers.
    来源
    Streptomyces rimosus
    应用
    A cytotoxic purine nucleoside
    储存/保存方法
    Store at 4° C
    形态
    Solid
    基本信息
    别名
    7-Deaza-7-carbamoyladenosine
    沸点
    880.6° C at 760 mmHg (Predicted)
    折射率
    n20D 1.89 (Predicted)
    IC50
    HFF: IC50 = 10 nM (human); L1210: IC50 = 3 nM (mouse); Human herpesvirus 5: IC50 = 30 nM; KB: IC50 = 80 nM (human); PKC: IC50 = 10 µM
    Ki 数据
    GRK 1: Ki= 180 nM (human); GRK 2: Ki= 67 µM (human)
    可溶性/溶解性
    Soluble in water (700 mg/L at 25 °C), chloroform (44.51 g/100mL at 25 °C), dichloromethane (19.20 g/100mL at 25 °C), methanol (9.98 g/100mL at 25 °C), DMSO (50 mM), ethanol (1.28 g/100mL at 25 °C)
    MDL
    MFCD00214391
    PubChem CID
    14978
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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