S3I-201
促销商品- S3I201, NSC74859, NSC 74859,NSC-74859, S3I 201
货号： abs810740
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810740-5mg | 现货 | - + | |
| abs810740-50mg | 现货 | - + |
大包装询价| 产品描述 | ||
| 描述 | S3I-201 (NSC 74859) is a Stat3 inhibitor with IC50 of 86 μM. | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | S3I201, NSC74859, NSC 74859,NSC-74859, S3I 201 | |
| 外观 | white to beige Powder | |
| 可溶性/溶解性 | DMSO ：36.5 mg/mL (100 mM) | |
| 生物活性 | ||
| 靶点 | STAT3 | |
| In vivo(体内研究) | Human breast (MDA-MB-231) tumor-bearing mice are given an i.v. injection of NSC 74859 (S3I-201) or vehicle every 2 or every 3 days for 2 weeks, and tumor measurements are taken every 2-3 days. Compared with control (vehicle-treated) tumors, which continued to grow, human breast tumors in mice that received S3I-201 display strong growth inhibition. Continued evaluation of treated mice on termination of treatment shows no resumption of tumor growth, suggesting potentially a long-lasting effect of S3I-201 on tumor growth. Compared with vehicle-treated control tumors (n=15), which continued to grow, S3I-201 treatment of somatotroph tumor xenografts (n=15) significantly attenuated tumor growth for the duration of the experiment. Tumors derived from NSC 74859-treated rats are significantly smaller than those from the untreated group (220±16 mm3 vs. 287±16 mm3, P3 vs. 708±83 mm3, P. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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- Allogeneic adipose‐derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF‐1α/IL‐10 pathway
Junchao Liu, Peng Qiu, Jinbao Qin, Xiaoyu Wu, Xin Wang, Xinrui Yang, Bo Li, Wenjie Zhang, Kaichuang Ye, Zhiyou Peng, Xinwu Lu
STEM CELLS. 2020 Jul 06 ; 10
影响因子： 6.022
Certificate of Analysis(COA)
