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  • S3I-201

    促销商品
    • S3I201, NSC74859, NSC 74859,NSC-74859, S3I 201
    货号: abs810740
    CAS号: 501919-59-1
    分子式: C16H15NO7S
    分子量: 365.36
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810740-5mg 现货 ¥415.00 ¥360.00
    - +
    abs810740-50mg 现货 ¥2133.00 ¥1200.00
    - +
    大包装询价
    产品描述
    描述

    S3I-201 (NSC 74859) is a Stat3 inhibitor with IC50 of 86 μM.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    S3I201, NSC74859, NSC 74859,NSC-74859, S3I 201
    外观
    white to beige Powder
    可溶性/溶解性
    DMSO :36.5 mg/mL (100 mM)
    生物活性
    靶点
    STAT3
    In vivo(体内研究)
    Human breast (MDA-MB-231) tumor-bearing mice are given an i.v. injection of NSC 74859 (S3I-201) or vehicle every 2 or every 3 days for 2 weeks, and tumor measurements are taken every 2-3 days. Compared with control (vehicle-treated) tumors, which continued to grow, human breast tumors in mice that received S3I-201 display strong growth inhibition. Continued evaluation of treated mice on termination of treatment shows no resumption of tumor growth, suggesting potentially a long-lasting effect of S3I-201 on tumor growth. Compared with vehicle-treated control tumors (n=15), which continued to grow, S3I-201 treatment of somatotroph tumor xenografts (n=15) significantly attenuated tumor growth for the duration of the experiment. Tumors derived from NSC 74859-treated rats are significantly smaller than those from the untreated group (220±16 mm3 vs. 287±16 mm3, P3 vs. 708±83 mm3, P.
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    • 实验方法 实验条件
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