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  • S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR)

    • S-(4-硝基苄基)-6-硫代肌苷
    货号: abs819687
    CAS号: 38048-32-7
    分子式: C17H17N5O6S
    分子量: 419.4
    产品说明书
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    货号-规格 货期 价格 数量
    abs819687-50mg 1-2周 ¥1979.00
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    产品描述
    描述

    S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) is a small molecule inhibitor of equilibrative nucleoside transporter (ENT) proteins. These transport proteins are described in relation to their sensitivity to NBMPR, designated as either es (NBMPR-sensitive) or ei (NBMPR-insensitive). They provide good research tools anticancer, antiviral, cardioprotective, and neuroprotective agents. Inhibition of ENT1 by NBMPR blocks the uptake and transport of adenosine, which affects the regulation of extracellular adenosine levels and the cardiac system signaling associated with adenosine.

    应用
    An inhibitor of ENTs with potential anticancer, cardio-, and neuro- protective properties
    纯度
    ≥98%
    使用方法
    Store stock solutions at -20°C or below and used within 1 month.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    S-(4-硝基苄基)-6-硫代肌苷
    外观
    solid
    熔点
    187-190° C (lit.)
    IC50
    Potent adenosine uptake and nucleoside transport : IC50 = 4.6 nM
    可溶性/溶解性
    Soluble in water (700 mg/L at 25 °C), chloroform (44.51 g/100mL at 25 °C), dichloromethane (19.20 g/100mL at 25 °C), methanol (9.98 g/100mL at 25 °C), DMSO (50 mM), ethanol (1.28 g/100mL at 25 °C)
    MDL
    MFCD00005745
    PubChem CID
    65407
    EC号码
    253-753-4
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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