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  • RGX-104

    • RGX 104;RGX104;CPD1632
    货号: abs814489
    CAS号: 610318-03-1
    分子式: C34H34Cl2F3NO3
    分子量: 632.54
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs814489-5mg 1-2周 ¥1874.00
    - +
    abs814489-10mg 1-2周 ¥3087.00
    - +
    abs814489-25mg 1-2周 ¥6064.00
    - +
    abs814489-50mg 1-2周 ¥9151.00
    - +
    大包装询价
    产品描述
    描述

    RGX-104 is a orally bioavailable liver X receptor agonist that modulates innate immunity via transcriptional activation of the ApoE gene. 

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    RGX 104;RGX104;CPD1632
    外观
    Powder
    可溶性/溶解性
    DMSO : ≥ 125 mg/mL (197.62 mM)
    生物活性
    靶点
    LXR
    In vitro(体外研究)
    RGX-104 is an oral first-in-class LXR agonist that robustly induces ApoE expression resulting in innate-immune mediated anti-tumor activity. RGX-104 drives anti-tumor immunity by regulating the abundance and activity of myeloid derived suppressor cells (MDSC) and dendritic cells (DC).
    In vivo(体内研究)
    Antitumor activity has been demonstrated with RGX-104 monotherapy in several syngeneic and xenograft tumor models, including melanoma, lung cancer, ovarian cancer, GBM and others. The anti-tumor activity of LXR-agonism is related to constitutive upregulation of ApoE expression.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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