Absin品牌现货抑制剂清单:
abs817925 |
Chlorpromazine hydrochloride |
50mg,100mg,500mg,1g |
靶点: 5-HT Receptor |
Chlorpromazine Hydrochloride 是一种有效的 dopamine D2 受体,5-HT2A 受体,potassium channel,sodium channel 的拮抗剂,抑制 D2 受体和 serotonin 5-HT2A 受体的活性,Ki 值分别为 363 nM 和 8.3 nM。 |
abs813682 |
Imipramine hydrochloride |
100mg |
靶点: 5-HT Receptor |
Imipramine is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination). |
abs817970 |
Olanzapine |
25mg,100mg |
靶点: 5-HT Receptor |
Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. |
abs814233 |
Ramosetron (Hydrochloride) |
50mg,100mg |
靶点: 5-HT Receptor |
Ramosetron Hydrochloride(YM060 Hydrochloride) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. |
abs816242 |
Captopril |
50mg,200mg,100mg |
靶点: ACE |
Captopril是一种血管紧张素转换酶(ACE)抑制剂,IC50为6 nM。 |
abs813513 |
Benztropine mesylate |
100mg,200mg,1g |
靶点: AChR |
Benztropine抑制MTSET诱导的[3H]WIN与野生型多巴胺转运蛋白结合的抑制,EC50为28 μM且具有浓度依赖特性。Benztropine对X-A342C DAT的保护率(EC50/抑制[3H]WIN (4nM)结合的IC50)为32,这是通过保护DAT342号半胱氨酸实现的。 在没有钠盐时W84L DAT对Benztropine的表观平衡解离常数明显高于野生型DAT,这种差异在[3H]CFT处理的HEK-293细胞并含有130 mM钠盐条件下变小了。 |
abs817411 |
Mecamylamine hydrochloride |
1mg,5mg,10mg |
靶点: AChR |
Mecamylamine hydrochloride is a nicotinic antagonist, used as a ganglionic blocker in hypertension. |
abs813918 |
PNU 282987 hydrochloride |
5mg,10mg,50mg,100mg |
靶点: AChR |
PNU-282987 is a highly selective α7 nicotinic acetylcholine receptor (α7 nAChR) agonist with Ki of 27 nM. PNU-282987 has no detectable agonist activity and negligible antagonist activity at the neuromuscular junction form of the receptor (α1β1γδ), the predominant ganglionic nAChR (α3β4), and the α4β2 subtype. PNU-282987 is found to be a functional antagonist of the 5-HT3 receptor with IC50 of ~4.5 μM. PNU-282987 displays potent activity at both α7-5HT3 chimera and native α7 nAChR. PNU-282987 is shown to open native alpha7 nAChRs in cultured rat neurons in a concentration-dependent manner, which can be blocked by MLA. Consistently, PNU-282987 reverse an amphetamine-induced gating deficit in rats. PNU-282987 is inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors with Ki of 930 nM. PNU-282987 enhances GABAergic synaptic activity when applied to hippocampal slices. Furthermore, PNU-282987 improves the inherent hippocampal gating deficit occurring in a subpopulation of anesthetized rats, and enhances amphetamine-induced hippocampal θ oscillation.Systemic administration of PNU-282987 significantly enhances the power (by 40%) of hippocampal theta oscillation induced by electrical stimulation of the brainstem reticular formation in anaesthetized rats, suggesting that precognitive actions of alpha7 nAChR agonists could be mediated, at least in part, by modulation of hippocampal oscillatory activity. |
abs816922 |
5'-AMP monohydrate |
10mg,50mg,100mg |
靶点: Adenosine Receptor |
Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-. |
abs811909 |
Theophylline |
100mg,200mg,500mg,1g |
靶点: Adenosine Receptor |
Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP. |
abs816196 |
ZM241385 |
10mg,50mg,200mg |
靶点: Adenosine Receptor |
ZM-241385 is a high affinity antagonist ligand selective for the <b>adenosine A2A receptor</b>. |
abs813466 |
AdipoRon |
10mg,25mg,50mg,100mg |
靶点: Adiponectin Receptor |
AdipoRon is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively. |
abs816457 |
Atenolol |
100mg,200mg,500mg |
靶点: Adrenergic Receptor |
Atenolol is a selective β1 receptor antagonist. |
abs814928 |
Brimonidine |
10mg,50mg |
靶点: Adrenergic Receptor |
Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist. |
abs816270 |
Clonidine hydrochloride |
100mg,200mg,500mg |
靶点: Adrenergic Receptor |
Clonidine hydrochloride (Catapres) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg. It treats high blood pressure by stimulating α2 receptors in the brain, which decreases cardiac output and peripheral vascular resistance, lowering blood pressure. It has specificity towards the presynaptic α2 receptors in the vasomotor center in the brainstem. This binding decreases presynaptic calcium levels, and inhibits the release of norepinephrine (NE). The net effect is a decrease in sympathetic tone. |
abs819242 |
Fenoterol hydrobromide |
100mg,1g |
靶点: adrenergic receptor |
Fenoterol溴酸盐是一个β 2肾上腺素能激动剂, 用于打通呼吸道到肺部, 被归类为交感神经β2激动剂和哮喘药物 |
abs813005 |
Isoproterenol Hydrochloride |
100mg,500mg |
靶点: Adrenergic Receptor |
Isoproterenol hydrochloride is a phenethylamine derivative and selective β-AR adrenergic agonist shown to increase cytosolic cAMP. Isoproterenol hydrochloride exhibits promotion of glycogen breakdown and causes bronchodilation and vasorelaxant effects. Also potentially stimulates relaxation in nitric oxide mediated endothelium-dependent smooth muscle. Isoproterenol Hydrochloride is an activator of β2-AR and ERK. |
abs813340 |
Mirabegron |
5mg,10mg,50mg |
靶点: Adrenergic Receptor |
Mirabegron是一种选择性的beta3-adrenoceptor(β3肾上腺素受体)激动剂,EC50为22.4 nM。 |
abs817064 |
Salbutamol |
10mg,25mg,50mg,100mg |
靶点: Adrenergic Receptor |
Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD). |
abs814913 |
Xylazine |
500mg,1g |
靶点: Adrenergic Receptor |
Xylazine (Rompun) is an α2 class of adrenergic receptor agonist. Xylazine is a clonidine analoque that acts on presynaptic and postsynaptic receptors of the central and peripheral nervous systems as an a 2-adrenergic agonist. |
abs815982 |
Yohimbine hydrochloride |
250mg,500mg,1g |
靶点: Adrenergic Receptor |
Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. |
abs817538 |
CH 223191 |
5mg,10mg,50mg |
靶点: AhR |
CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM. |
abs814131 |
ITE |
50mg,100mg |
靶点: AhR |
ITE is an Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). |
abs822722 |
Tapinarof |
5mg,25mg |
靶点: AhR |
Tapinarof is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. |
abs810633 |
GDC-0068 |
5mg,10mg,50mg,100mg |
靶点: Akt |
GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. |
abs812028 |
GSK690693 |
10mg,50mg |
靶点: Akt |
GSK690693是 一种泛Akt抑制剂,靶向作用于Akt1/2/3,在无细胞试验中IC50为2 nM/13 nM/9 nM,也对AGC激酶家族:PKA,PrkX和PKC同工酶敏感。 |
abs810621 |
MK-2206 2HCl |
5mg,10mg,50mg,100mg |
靶点: Akt |
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2. |
abs810467 |
Perifosine |
5mg,10mg,50mg,100mg |
靶点: Akt |
Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM. |
abs810216 |
SC-79 |
5mg,10mg,50mg,100mg |
靶点: Akt |
SC-79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. |
abs812124 |
AZD5363 |
5mg,10mg,25mg,50mg |
靶点: Akt;Autophagy |
AZD5363有效抑制Akt(Akt1/Akt2/3)的所有亚型,在无细胞试验中IC50为3 nM/8 nM/8 nM,对P70S6K/PKA也具有相似的抑制效果,而对ROCK1/2抑制活性较低。 |
abs810155 |
Alda-1 |
5mg,10mg,50mg,100mg |
靶点: ALDH |
Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). |
abs810526 |
DMH1 |
10mg,25mg,50mg,100mg |
靶点: ALK |
DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. |
abs815934 |
Vitamin B12 |
25mg,50mg,100mg,200mg |
靶点: Alkaloids |
Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. |
abs815911 |
Bestatin |
10mg,20mg,50mg,100mg |
靶点: Aminopeptidase |
Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage, and bone marrow stem cell as well as stimulates the release of interleukin-1 and -2, thus further enhances its antitumor activity. |
abs813003 |
(S)-AMPA |
1mg,5mg |
靶点: AMPAR |
(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid is an active enantiomer of AMPA ((R,S)-AMPA) that induces apoptotic cell death in cortical neurons. Does not exhibit any affinity for NMDA receptors. (S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid is an activator of GluR. |
abs812835 |
CNQX |
10mg,25mg |
靶点: AMPAR |
CNQX (FG9065) 是高效的 AMPA/kainate 受体拮抗剂。 |
abs812836 |
CNQX disodium salt |
10mg,25mg |
靶点: AMPAR |
CNQX disodium salt is a potent and competitive GluR (kainate/quisqualate (non-NMDA) receptor) antagonist. It also shows antagonism of the NMDA receptor at the glycine modulatory site. It is a more water soluble form of CNQX. |
abs812842 |
DNQX |
10mg,50mg |
靶点: AMPAR |
DNQX is a non-N-methyl-D-aspartate (non-NMDA) receptor complex antagonist. The compound has been shown to attenuate JNK3 activation and has been shown not to stimulate a robust long-term potentiation in hippocampul studies. 6,7-Dinitroquinoxaline-2,3-dione (DNQX) is an inhibitor of GluR. |
abs813008 |
L-Quisqualic acid |
5mg,25mg |
靶点: AMPAR |
L-Quisqualic acid acts as an agonist for mGluR-1 (metabotropic glutamate receptor 1), and can be used to differentiate between mGluR-1 and mGluR-4. It has been reported to induce a slow K(+)-current response in B6 neurons of Aplysia buccal ganglia. It has been shown to inhibit human PSM (glutamate carboxypeptidase II, GCPII), an enzyme of the central nervous system and the human prostate, and may thus provide neuroprotection and could be useful for the imaging, detection, and treatment of prostate cancer. It has also been shown to increase the release of acetylcholine from the rat hippocampus and striatum. L-Quisqualic acid is an activator of GluR. |
abs813006 |
NBQX |
5mg,25mg |
靶点: AMPAR |
NBQX is a potent, selective and competitive AMPA receptor antagonist. |
abs812848 |
NBQX disodium salt |
1mg,5mg,25mg |
靶点: AMPAR |
NBQX disodium salt is a water soluble, selective, and potent GluR (AMPA/kainate receptor) antagonist. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. |
abs810657 |
A-769662 |
5mg,10mg,50mg,100mg |
靶点: AMPK |
A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity. |
abs812834 |
AICAR |
100mg,500mg |
靶点: AMPK |
AICAR (阿卡地新; Acadesine) 是AMPK活化剂,可作用于急性淋巴细胞白血病。 |
abs810530 |
Dorsomorphin free base |
5mg,50mg |
靶点: AMPK |
Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), B |
abs810529 |
Dorsomorphin-2HCl |
5mg,10mg,50mg,100mg,500mg |
靶点: AMPK |
Dorsomorphin 2Hcl (Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits ALK2, ALK3, and ALK 6 . |
abs810156 |
FPS-ZM1 |
5mg,10mg,50mg,100mg |
靶点: Amyloid-β |
FPS-ZM1 is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively. |
abs816001 |
MK-0752 |
5mg,10mg,50mg |
靶点: Amyloid-β |
MK-0752 is a moderately potent <b>γ-secretase</b> inhibitor, which reduces Aβ40 production with <b>IC50</b> of 5 nM. Phase 1/2. |
abs820713 |
PE859 |
1mg,5mg |
靶点: Amyloid-β |
PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. |
abs812898 |
Deferoxamine Mesylate |
50mg,100mg,500mg,1g |
靶点: Amyloid-β;Mitophagy;Autophagy |
Deferoxamine mesylate 是一种铁离子螯合剂,能够有效减少氧化应激和神经元的死亡。 |
abs817935 |
Bicalutamide |
50mg,100mg,500mg |
靶点: Androgen Receptor |
Bicalutamide 是非甾体抗雄激素化合物,能与雄激素受体结合,可作用于前列腺癌,IC50为0.16 μM。 |
abs817962 |
Dehydroepiandrosterone |
50mg,100mg,200mg,500mg |
靶点: Androgen Receptor |
Dehydroepiandrosterone (DHEA) has potential chemopreventive activity. Produced endogenously, DHEA is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. |
abs810669 |
Enzalutamide |
5mg,10mg,50mg,100mg |
靶点: Androgen Receptor |
MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM. |
abs816702 |
Flutamide |
50mg,500mg |
靶点: Androgen Receptor |
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor. |
abs810055 |
RAD140 |
5mg,10mg,50mg,100mg |
靶点: Androgen Receptor |
RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). |
abs815922 |
Telmisartan |
50mg,100mg,500mg |
靶点: Angiotensin Receptor |
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. |
abs817006 |
Amoxicillin |
10mg,200mg |
靶点: Antibacterial |
Amoxicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Amoxicillin Anhydrous is the anhydrous form of a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. |
abs813004 |
Carbenicillin disodium salt |
250mg,1g |
靶点: Antibacterial |
Carbenicillin disodium salt is a penicillin-derived, β-lactam antibiotic which inhibits the synthesis of peptidoglycan, a key component of the bacterial cell wall. In studies investigating the roles of biogenic polyamines, spermidine and spermine, on antibiotic susceptibility of several microorganisms it was observed that the mean inhibitory concentration (MIC) of β-lactam antibiotics such as Carbenicillin was decreased with the addition of spermidine and spermine to cultures of Escherichia coli and Salmonella enterica. Additionally, in plants Carbenicillin was investigated for its effects on morphology and growth of Beta vulgaris, Capsicum annuum and Glehnia littoralis roots. In this study, Carbenicillin was noted to inhibit root elongation while promoting root branching in contrast to Ampicillin . |
abs813546 |
Cetylpyridinium Chloride |
50mg,100mg |
靶点: Antibacterial |
Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic. |
abs817097 |
Chloramphenicol |
200mg,1g,5g |
靶点: Antibacterial |
Chloramphenicol is a broad-spectrum antibiotic. |
abs812865 |
Doxycycline Hyclate |
50mg,500mg |
靶点: Antibacterial |
Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. |
abs810644 |
Ertapenem |
5mg,50mg |
靶点: Antibacterial |
Ertapenem is a long-acting, broad-spectrum antibiotic that is in the β-lactam subclass known as carbapenems. It inhibits the synthesis of bacterial cell walls by attaching to penicillin-binding proteins. |
abs810643 |
Ertapenem Sodium |
10mg,50mg |
靶点: Antibacterial |
Ertapenem Sodium |
abs812846 |
Geneticin (G418 Sulfate) |
250mg,500mg,5g |
靶点: Antibacterial |
G418 (Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1; blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. |
abs814119 |
Lefamulin(BC-3781) |
25mg,50mg |
靶点: Antibacterial |
Lefamulin is a semi-synthetic compound that inhibits the synthesis of bacterial protein, which is required for bacteria to grow. Lefamulin acts by binding to the peptidyl transferase center, or PTC, on the bacterial ribosome in such a way that it interferes with the interaction of protein production at two key sites known as the “A” site and the “P” site, resulting in the inhibition of bacterial proteins and the cessation of bacterial growth. Lefamulin’s binding occurs with high affinity, high specificity and at molecular sites that are different than other antibiotic classes. |
abs812975 |
Monensin sodium salt |
25mg,100mg,50mg,1ml*10mM(Ethanol) |
靶点: Antibacterial |
Sodium Monensin, isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. |
abs816887 |
Spectinomycin dihydrochloride pentahydrate |
25mg,100mg |
靶点: Antibacterial |
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. |
abs814442 |
streptomycin |
50mg,100mg |
靶点: Antibacterial |
本体通过作用于细菌体内的核糖体,抑制细菌蛋白质合成,并破坏细菌细胞膜的完整性。 |
abs816955 |
Tetracycline |
50mg,100mg,500mg |
靶点: Antibacterial |
Tetracycline is a naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. |
abs813926 |
Thiamphenicol |
20mg,50mg,100mg,200mg |
靶点: Antibacterial |
Thiamphenicol (Thiophenicol) is an antimicrobial antibiotic and a methyl-sulfonyl analogue of chloramphenicol. Thiamphenicol (Thiophenicol) has a similar antibacterial spectrum to chloramphenicol. Thiamphenicol (Thiophenicol) inhibits protein synthesis in bacteria. Thiamphenicol (Thiophenicol) has a bacteriostatic action against a broad range of microorganisms, although it may be bactericidal for some species under some conditions, and in concentrations 3 to 5 times higher than the bacteriostatic concentrations. Thiamphenicol (Thiophenicol) is particularly used for the treatment of sexually transmitted infections and pelvic inflammatory disease. |
abs817545 |
Ascomycin (FK520) |
5mg,10mg,25mg,50mg |
靶点: Antifungal |
Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3. |
abs813976 |
Nystatin |
50mg,100mg,200mg,500mg |
靶点: Antifungal |
Nystatin (Mycostatin) is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections. Nystatin interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. |
abs816307 |
Nitazoxanide |
25mg,50mg,100mg |
靶点: Antiparasitic |
Nitazoxanide (Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM) The anti- protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. It has also been shown to have activity against influenza A virus. Nitazoxanide and tizoxanide inhibited virus replication of all canine influenza virus with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively. |
abs814525 |
FIN56 |
5mg,25mg,50mg,100mg |
靶点: Apoptosis Inducer |
FIN56 is a specific inducer of ferroptosis . |
abs816203 |
NSC348884 |
5mg,25mg,100mg |
靶点: Apoptosis Inducer |
NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM. |
abs810535 |
AZ20 |
5mg,10mg,50mg,100mg |
靶点: ATM/ATR |
AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR. |
abs812170 |
KU-55933 (ATM Kinase Inhibitor) |
5mg,10mg,50mg |
靶点: ATM/ATR |
KU-55933 (ATM Kinase Inhibitor)是一种有效的,特异性ATM抑制剂,在无细胞试验中IC50/Ki为12.9 nM/2.2 nM,与DNA-PK, PI3K/PI4K, ATR和mTOR相比,对ATM具有高度选择性。 |
abs813881 |
VE-822 |
5mg,10mg,25mg,50mg |
靶点: ATM/ATR |
VE-822是选择性ATR抑制剂,Ki< 0.2 nM,ATR选择性比高相关性的PI3K关联酶ATM/DNA-PK高了170倍。作为对XRT和gemcitabine的响应,VE-822(80 nM)减弱ATR信号传导途径,并降低肿瘤细胞存活率。在正常细胞中,VE-822(80 nM)减弱ATR信号通路强度,但并没有增强辐射和gemcitabine杀伤正常细胞的能力。与XRT中的MiaPaCa-2和PSN-1细胞相比,VE-822(80 nM)增加XRT引起的残余γH2AX和53BP1灶。 |
abs810012 |
Brefeldin A |
10mg,1mL*10mM(DMSO),25mg |
靶点: ATPase |
布雷菲德菌素A(BrefeldinA)是一种内酯抗生素和ATPase抑制剂,作用于蛋白质转运,在HCT 116细胞中IC50为0.2μM,诱导癌细胞分化和凋亡。BrefeldinA是一种真菌代谢产物,抑制内质网和高尔基体之间的传输,BrefeldinA导致膜蛋白分布受损。BrefeldinA作用于肿瘤细胞,主要通过诱导分化和凋亡而发挥其细胞毒性作用。 |
abs817431 |
Sodium orthovanadate |
100mg,500mg |
靶点: ATPase |
Sodium orthovanadate is a commonly used general inhibitor for PTP (protein tyrosine phosphatases), alkaline phosphatase (ALP) and ATPase. Na3VO4 acts as a competitive inhibitor and is completely reversible upon the addition of EDTA or by dilution. The PTP activities are conveniently separable from the protein phosphoseryl and phosphothreonyl phosphatase (PSP) activities inhibited by Fluoride and EDTA. Vanadate is routinely used to preserve the protein tyrosyl phosphorylation state in cells, cell lysates, and protein tyrosine kinase assays. Sodium Orthovanadate is an inhibitor of AK and PFK. |
abs812122 |
Barasertib (AZD1152-HQPA) |
5mg,10mg,50mg |
靶点: Aurora Kinase |
Barasertib (AZD1152-HQPA)是一种高度选择性的Aurora B抑制剂,无细胞试验中IC50为0.37 nM,作用于Aurora B比作用于Aurora A选择性高3700倍左右。 |
abs812081 |
VX-680 (Tozasertib, MK-0457) |
25mg,100mg,250mg |
靶点: Aurora Kinase;Autophagy |
VX-680 (Tozasertib, MK-0457)是一种pan-Aurora抑制剂,对Aurora A作用最强,无细胞试验中Kiapp为0.6 nM,而对Aurora B/Aurora C的作用较弱,对Aurora A选择性比其他55种激酶高100倍。 |
abs811001 |
MLN8237 |
5mg,10mg,50mg |
靶点: Aurora Kinase;Autophagy;Apoptosis |
MLN8237 (Alisertib) is a selective Aurora kinase A inhibitor with a median IC50 of 61 nM. |
abs819061 |
3PO |
5mg,25mg |
靶点: Autophagy |
3PO is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH. |
abs816050 |
Hydroxychloroquine Sulfate |
50mg,200mg |
靶点: Autophagy |
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. |
abs817883 |
Metformin hydrochloride |
100mg,500mg,1g |
靶点: Autophagy |
Metformin hydrochloride 是一种双胍类降糖药,用于治疗对饮食调整没有反应的非胰岛素依赖型糖尿病。 |
abs810549 |
PFK-15 |
5mg,10mg,50mg,100mg |
靶点: Autophagy |
PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancer cells with IC50 of 20 nM. |
abs810392 |
GSK2606414 |
5mg,10mg,25mg,50mg |
靶点: Autophagy;PERK |
GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM. |
abs810160 |
LY3009120 |
5mg,10mg,50mg,100mg |
靶点: Autophagy;Raf |
LY3009120 is a potent and selective pan-RAF inhibitor with potential anticancer activity. |
abs817900 |
Verteporfin |
5mg,10mg,25mg,50mg |
靶点: Autophagy;YAP |
Verteporfin 是苯并卟啉衍生物,是一种光敏剂,用于光动力学疗法。 |
abs817597 |
A-1210477 |
5mg,10mg,50mg |
靶点: Bcl-2 |
A-1210477 is a potent and selective MCL-1 and Bcl-2 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members. |
abs810559 |
ABT-199 |
5mg,50mg,1g |
靶点: Bcl-2 |
Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 3. |
abs812113 |
ABT-263 (Navitoclax) |
5mg,10mg,25mg,50mg |
靶点: Bcl-2 |
ABT-263 (Navitoclax)是一种有效的Bcl-xL,Bcl-2和Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。 |
abs810729 |
Dasatinib |
25mg,200mg |
靶点: Bcr-Abl |
Dasatinib (BMS-354825, Sprycel) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.5 nM and 79 nM, respectively. |
abs810705 |
PTC-209 |
5mg,10mg,50mg,100mg |
靶点: BMI-1;Autophagy |
PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 uM in in both GEMS reporter and ELISA assays. |
abs810419 |
Ibrutinib |
5mg,50mg,100mg |
靶点: BTK |
PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM. |
abs816418 |
Neomycin sulfate |
100mg,200mg,500mg,1g |
靶点: Calcium Channel |
Neomycin sulphate?belongs to a class of antibiotics known as the aminoglycosides. Neomycin sulphate belongs to a class of antibiotics known as the aminoglycosides. Neomycin sulphate is bactericidal in action (kills bacteria). Neomycin sulphate (Neomycin sulphate) does this by causing the bacteria to produce defective proteins which are essential for their growth. Neomycin sulphate is an antibiotic, active against many strains of Gram-positive and Gram-negative bacteria including Staph. aureus, E. coli, Klebsiella spp., H. influenzae, S. typhi, Shigella and Mycobacterium tuberculosis. It is ineffective against fungi and viruses. |
abs812833 |
1-EBIO |
1mg,5mg,10mg,50mg,1g |
靶点: Calcium channel |
1-Ethyl-2-benzimidazolinone is a calium channel agonist. |
abs816169 |
Bay K 8644 |
5mg,10mg,25mg,100mg |
靶点: Calcium Channel |
Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. |
abs813709 |
Lomerizine hydrochloride |
25mg,50mg,100mg,200mg |
靶点: Calcium Channel |
Lomerizine dihydrochloride is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine. |
abs816300 |
Nifedipine |
500mg,1g,5g |
靶点: Calcium Channel |
Nifedipine (Adalat), a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Nifedipine (Adalat) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal’s angina) and antihypertensive, although a large number of other uses have recently been found for this agent, such as Raynaud’s phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers. |
abs816033 |
Verapamil hydrochloride |
20mg,50mg,200mg |
靶点: Calcium Channel |
Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent. |
abs810421 |
KN-93 Phosphate |
5mg,10mg,50mg,100mg |
靶点: CaMK |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
abs810050 |
Forskolin |
5mg,25mg,100mg |
靶点: cAMP |
Forskolin在各种各样细胞类型中,是一种普遍存在的真核细胞腺苷酸环化酶(AC)激活剂,在细胞生理学研究中,通常用来提高cAMP水平。Forskolin可以使膜,细胞或组织制备液中cAMP含量上升。Forskolin 不仅可以活化AC 而且可以与某些其它蛋白相互作用,包括葡萄糖转运蛋白和离子通道。Forskolin在不与细胞表面受体相互作用前提下刺激腺苷酸环化酶活性。在脂肪细胞中Forskolin's促进 cAMP产生进而可以抑制嗜碱性粒细胞和肥大细胞脱颗粒作用以及组胺释放,降低血压、眼内压,抑制血小板聚集,促进血管舒张,支气管扩张和甲状腺激素分泌,刺激脂肪分解。Forskolin抑制血小板活化因子 (PAF)的结合, 这种抑制不依赖于cAMP形成可能是 Forskolin's直接作用于 PAF或者通过干扰PAF与它的受体结合实现的。Forskolin似乎对多种膜转运蛋白也有效果并且可以抑制脂肪细胞,红细胞,血小板,和其他细胞中的葡萄糖运输。Forskolin也被用于治疗青光眼。 |
abs810117 |
Iodopravadoline(AM-630) |
5mg,10mg,50mg,100mg |
靶点: Cannabinoid Receptor |
AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 μM and 31.2 nM, respectively. |
abs810695 |
WIN-55212-2 mesylate |
5mg,100mg |
靶点: Cannabinoid Receptor |
WIN 55212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. |
abs812901 |
Emodin |
50mg,100mg |
靶点: Casein Kinase |
Emodin 是一种广谱抗癌剂。Emodin 抑制蛋白激酶CK2 (IC50 为 2 μM。 |
abs814789 |
AS 101 |
10mg,50mg |
靶点: Caspase |
AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. |
abs810484 |
PAC-1 |
10mg,25mg,50mg,100mg |
靶点: Caspase |
PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3. |
abs812064 |
VX765 |
10mg,50mg |
靶点: Caspase |
Belnacasan (VX-765)是一种有效的选择性caspase-1抑制剂,无细胞试验中Ki为0.8 nM。 |
abs812077 |
Z-DEVD-FMK |
1mg,5mg |
靶点: Caspase |
Z-DEVD-FMK是一种特异性,不可逆的Caspase-3抑制剂,也能有效抑制caspase-6, caspase-7, caspase-8和caspase-10。 |
abs813891 |
Z-IETD-FMK |
1mg,5mg |
靶点: Caspase |
Z-IETD-FMK is a specific Caspase-8 inhibitor. |
abs812078 |
Z-VAD-FMK |
1mg,5mg |
靶点: Caspase |
Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。 |
abs812152 |
Dinaciclib (SCH727965) |
5mg,25mg,50mg |
靶点: CDK |
Dinaciclib (SCH727965)是一种新型有效的CDK抑制剂,作用于CDK2,CDK5,CDK1和CDK9,无细胞试验中IC50分别为1 nM,1 nM,3 nM和4 nM。它也会阻断胸甘(dThd) DNA整合。 |
abs811515 |
LDC000067 |
10mg,50mg |
靶点: CDK |
LDC000067 is a highly selective CDK9 inhibitor . |
abs810424 |
LEE011 |
5mg,50mg |
靶点: CDK |
LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
abs817903 |
LY2835219 |
5mg,10mg,25mg,100mg |
靶点: CDK |
LY2835219对CDK4和CDK6的IC50分别为2 nM和10 nM。 |
abs810149 |
Palbociclib isethionate |
5mg,10mg,50mg,100mg |
靶点: CDK |
Palbociclib isethionate(PD-0332991 isethionate) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. |
abs810516 |
PD0332991 HCl |
5mg,10mg,50mg,100mg |
靶点: CDK |
Palbociclib is an oral, small molecule cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, now in Phase 3 clinical development for advanced breast cancer. |
abs810696 |
PD0332991(free base) |
5mg,100mg,1g |
靶点: CDK |
Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. |
abs810659 |
RO-3306 |
5mg,10mg,50mg,100mg |
靶点: CDK |
Ro-3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D. |
abs810366 |
SNS-032 |
5mg,10mg,50mg,100mg |
靶点: CDK |
SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). |
abs810415 |
AZD-7762 |
5mg,10mg,50mg,100mg |
靶点: Chk |
AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM; equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. |
abs812861 |
Imatinib mesylate |
50mg,100mg |
靶点: c-Kit |
Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
abs817884 |
Imatinib |
50mg,500mg |
靶点: c-Kit;PDGFR;Autophagy |
Imatinib (STI571)是一种多靶点酪氨酸激酶抑制剂,作用于v- v-Abl, c-Kit和PDGFR 时,IC50分别为0.6, 0.1和0.1 μM。 |
abs813646 |
Flufenamic acid |
25mg,50mg,100mg,200mg |
靶点: COX |
Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator. |
abs817976 |
Indomethacin |
50mg,200mg,500mg |
靶点: COX |
Indomethacin是非甾体抗炎化合物,可作用于发烧,肿胀和疼痛等。 |
abs813979 |
Meloxicam |
50mg,100mg,200mg,500mg |
靶点: COX |
Meloxicam (Mobic) is a nonsteroidal anti-inflammatory drug with analgesic and fever reducer effects. Meloxicam inhibits cyclooxygenase (COX), the enzyme responsible for converting arachidonic acid into prostaglandin H2--the first step in the synthesis of prostaglandins, which are mediators of inflammation. Meloxicam has been shown, especially at its low therapeutic dose, selectively to inhibit COX-2 over COX-1. |
abs816427 |
Naproxen sodium |
50mg,500mg |
靶点: COX |
Naproxen 是一种非选择性环氧合酶(COX)抑制剂,作用于COX-1和COX-2时,IC50分别为8.7 μM和5.2 μM。Naproxen作用于完整细胞,抑制COX-1和 COX-2效果差不多,IC50分别为2.2 μg/mL和1.3 μg/mL。 在体外,Naproxen作用于大鼠和人类,降低LPS诱导的PGE2和TXB2产量,抑制PGE2 时,IC50分别为30.7 μM和79.5 μM,抑制TXB2时,IC50 分别为72.4 μM 和48.3 μM。 Naproxen抑制人血小板TXB2产量和LPS诱导的人单核细胞TXB2 产量,IC50分别为5.7和6.4, 也稍微选择性抑制组成型和诱导型COX-2,作用于COX-1的IC50值与作用于COX-2 的IC50值之比为6.3。 |
abs816060 |
Salicylic acid |
100mg,500mg,1g |
靶点: COX |
Salicylic acid, a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase. |
abs812197 |
Plerixafor (AMD3100) |
5mg,10mg,50mg,100mg |
靶点: CXCR |
Plerixafor (AMD3100)是一种趋化因子受体拮抗剂,作用于CXCR4和CXCL12介导的趋化性,无细胞试验中IC50分别为44 nM和5.7 nM。 |
abs817864 |
Calpeptin |
10mg,50mg |
靶点: Cysteine Protease |
Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. |
abs812017 |
E-64 |
10mg,25mg |
靶点: Cysteine Protease |
E-64 is a natural, potent, and irreversible inhibitor of cysteine proteases; IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively. |
abs817702 |
N-Ethylmaleimide |
25mg,50mg,100mg,200mg |
靶点: Cysteine Protease |
N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies |
abs812852 |
PMSF |
50mg,100mg,200mg |
靶点: Cysteine Protease |
PMSF (Phenylmethanesulfonyl fluoride) is an irreversible inhibitor of serine proteinases, which is associated with the development of the delayed organophosphorus neuropathy. It has a role in a lot of cellular repair and regeneration processes in many kinds of tissues. PMSF is a long acting Neuropathy Target Esterase (NTE) inhibitor. NTE is a protection was related to inhibition of the putative target of organophosphate-induced delayed polyneuropathy (OPIDP). PMSF can increase NTE inhibition to more than 90%. PMSF also acts as an active site directed reagent for γ-glutamyl transpeptidase. |
abs813404 |
Leflunomide |
25mg,50mg,100mg,200mg |
靶点: Dehydrogenase |
Leflunomide (HWA486)是一种免疫抑制剂,其活性代谢产物为Teriflunomide。 |
abs812856 |
Teriflunomide |
50mg,100mg |
靶点: Dehydrogenase |
Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent. |
abs817923 |
Methotrexate |
50mg,100mg,200mg,500mg |
靶点: DHFR |
Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties. |
abs811952 |
Triptolide (PG490) |
1mg,5mg |
靶点: Diterpenoids |
Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii. |
abs810466 |
Cisplatin |
5mg,50mg |
靶点: DNA Alkylator/Crosslinker |
Cisplatin is an inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. |
abs815950 |
Cyclophosphamide Monohydrate |
50mg |
靶点: DNA Alkylator/Crosslinker |
Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA. |
abs817879 |
Decitabine |
10mg,25mg,50mg |
靶点: DNA Methyltransferase |
Decitabine是一种有效的DNA甲基化抑制剂,作用于HL-60和KG1a细胞时,IC50分别为100 ng/mL和1 ng/mL。 |
abs818568 |
Zebularine |
10mg,50mg |
靶点: DNA Methyltransferase |
Zebularine is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM in a cell-free assay. |
abs817898 |
5-Fluorouracil |
5mg,50mg,100mg,200mg |
靶点: DNA/RNA Synthesis |
Fluorouracil (5-Fluoracil, 5-FU)是DNA/RNA合成抑制剂,通过抑制胸苷酸合成酶(TS)而干扰核苷酸合成。 |
abs817895 |
Bleomycin Sulfate |
10mg,50mg |
靶点: DNA/RNA Synthesis |
Bleomycin Sulfate是一种糖肽类抗生素,作用于UT-SCC-19A细胞,IC50为4 nM。 |
abs811906 |
Brdu |
50mg,200mg |
靶点: DNA/RNA Synthesis |
Brdu,中文全名5-溴脱氧尿嘧啶核苷,为胸腺嘧啶的衍生物,可代替胸腺嘧啶在DNA合成期(S期),活体注射或细胞培养加入,而后利用抗Brdu单克隆抗体,ICC染色,显示增殖细胞。同时结合其它细胞标记物,双重染色,可判断增殖细胞的种类,增殖速度,对研究细胞动力学有重要意义。 目前常用的细胞增殖标记物有4种,Brdu (5-bromo-2--deoxyuridine), DNA polymerase α,PCNA ,Ki-67 等。因组织细胞内无内源性Brdu存在,所以Brdu应用较广。 |
abs813303 |
Capecitabine |
50mg,100mg,500mg |
靶点: DNA/RNA Synthesis |
Prodrug of 5-Fluorouracil (5-FU). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available. |
abs817679 |
Cordycepin |
10mg,25mg,100mg,200mg |
靶点: DNA/RNA Synthesis |
Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity. Extracted?from?Cordyceps;Store?the?product?in?sealed,?cool?and?dry?condition |
abs812845 |
Folic acid |
100mg,500mg |
靶点: DNA/RNA Synthesis |
Folic acid(Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis. |
abs814679 |
Gemcitabine |
10mg,50mg,100mg,200mg |
靶点: DNA/RNA Synthesis |
Gemcitabine is a nucleoside metabolic inhibitor in PANC1(IC50=50 nM), MIAPaCa2(IC50=40 nM), BxPC3(IC50=18 nM) and Capan2 cells(IC50=12 nM). |
abs810450 |
PSI-7977 |
5mg,100mg |
靶点: DNA/RNA Synthesis |
PSI-7977 is an investigational nucleotide analog currently in Phase 2 for treatment of chronic HCV infection. |
abs810434 |
PR-619 |
5mg,10mg,50mg,100mg |
靶点: DUB |
PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. |
abs817172 |
Crystal Violet |
25mg,50mg,100mg,200mg |
靶点: Dye Reagent |
Crystal violet is a triarylmethane dye that is a mixture of violet rosanilinis, with antibacterial, antifungal, and anthelmintic properties. |
abs810256 |
Dihydroethidium |
5mg,10mg,50mg,100mg |
靶点: Dye Reagent |
Dihydroethidium(Hydroethidine; PD-MY 003) is a superoxide indicator; exhibits blue-fluorescence in the cytosol until oxidized, where it intercalates within the cell's DNA, staining its nucleus a bright fluorescent red. |
abs816408 |
Indocyanine green |
50mg,100mg,500mg |
靶点: Dye Reagent |
Indocyanine green (Cardiogreen) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow,and for ophthalmic angiography. It has a peak spectral absorption at about 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than Fluorescein angiography. ICG binds tightly to plasma proteins and becomes confined to the vascular system. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver to bile juice. |
abs810482 |
Dynasore |
5mg,10mg,50mg,100mg |
靶点: Dynamin |
Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. |
abs810678 |
Afatinib (BIBW2992) |
5mg,50mg,1g |
靶点: EGFR |
BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively. |
abs810014 |
AG 490 |
5mg,10mg,25mg,50mg |
靶点: EGFR |
AG-490 (Tyrphostin B42)是一种EGFR抑制剂,在无细胞试验中IC50为0.1μM,作用于EGFR比作用于ErbB2选择性高135倍,对JAK2也有抑制作用,对Lck,Lyn,Btk,Syk和Src没有抑制活性。 |
abs810718 |
AZD-9291 |
5mg,50mg |
靶点: EGFR |
AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM). |
abs812013 |
Canertinib (CI1033) |
10mg,25mg,50mg,100mg |
靶点: EGFR |
Canertinib (CI-1033) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Phase 3. |
abs810004 |
Genistein |
5mg,10mg,50mg |
靶点: EGFR |
Genistein(NPI 031L)是豆制品中的植物雌激素,是PTK特异性抑制剂,能阻断EGF或胰岛素介导的NIH-3T3有丝分裂,IC50分别为12μM和19μM。 Genistein是一个ATP竞争性抑制剂。在离体酶,受体制剂和包括血小板、淋巴球的整个细胞以及各种各样人工培养的细胞中,Genistein抑制酪氨酸磷酸化。Genistein也会抑制人工培养细胞中EGF受激的磷酸化作用,并且也会抑制Topo II (拓扑异构酶 II)。Genistein抑制人工培养的A431表皮样癌细胞中EGF受激的酪氨酸磷酸化。抑制作用与ATP竞争,而不与基底竞争。Genistein阻断NIH-3T3 细胞中EGF,胰岛素和凝血酶介导的促有丝分裂作用。Genistein也充当GPR30受体的激动剂,结合于PPARγ和雌激素受体。Genistein也结合于PPARγ,作为该受体的激动剂,其Ki为 5.7μM。 Genistein对成年动物的乳腺癌,前列腺癌和其它内分泌依赖性肿瘤具有预防作用。Genistein在饮食中剂量依赖性减少了低分化前列腺癌的发病率,下调了雄性激素受体,雌激素受体-α,孕激素受体,表皮生长因子受体,胰岛素样生长因子-I和胞外信号调节激酶-1,但不影响雌激素受体-β和转化生长因子-α的mRNA的表达。膳食genistein可以通过调节特定性激素受体和生长因子信号通路预防乳腺癌和前列腺癌。Genistein与前列腺肿瘤辐射结合更加抑制了原发性肿瘤的生长,并且增加了对其自发性转移到主动脉旁淋巴结的控制,提高了小鼠存活率。奇怪的是,Genistein单独治疗增加了其到淋巴结的转移。 |
abs812860 |
Lapatinib(free base) |
25mg,100mg |
靶点: EGFR |
Lapatinib,以 Lapatinib Ditosylate的形式使用,是一种有效的EGFR和ErbB2抑制剂,在无细胞试验中IC50分别为10.2和9.8 nM。 |
abs810455 |
WZ-4002 |
5mg,10mg,50mg,100mg |
靶点: EGFR |
WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I). |
abs812854 |
Gefitinib (ZD1839) |
10mg,100mg |
靶点: EGFR;Autophagy |
Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. |
abs818039 |
Stearic acid |
25mg,50mg,100mg,200mg |
靶点: Endogenous Metabolite |
1. Stearic Acid can reduce metastatic tumor burden. 2. Stearic Acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes. 3. Stearic Acid and its derivatives have been used as gelators in food and pharmaceutical gel formulations. 4. Stearic Acid is a potent phosphatase 1B inhibitor, possibly causing an enhancement in the insulin receptor signaling to stimulate glucose uptake into adipocytes. 5. Stearic Acid has the potential to increase dry matter intake and yields of milk and milk components, without affecting conversion of feed to milk, body condition score, or body weight. |
abs817643 |
Cyclopamine |
5mg,10mg,25mg,50mg |
靶点: Endogenous Metabolite;Hedgehog |
Cyclopamine is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). |
abs822945 |
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine |
500ug,5mg |
靶点: Endothelin Receptor |
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way. |
abs810733 |
(+)-JQ-1 |
5mg,50mg,1g |
靶点: Epigenetic Reader Domain |
(+)-JQ1 is a BET bromodomain inhibitor, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. |
abs814013 |
EED-226 |
50mg,100mg |
靶点: Epigenetic Reader Domain |
EED226 is a potent and selective PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED. |
abs811323 |
GDC0994 |
5mg,10mg |
靶点: ERK |
GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. |
abs810767 |
SCH-772984 |
5mg,10mg,50mg |
靶点: ERK |
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
abs810342 |
XMD8-92 |
5mg,10mg,50mg,100mg |
靶点: ERK |
XMD8-92 is highly selective ERK5/BMK1 inhibitor with Kd values of 80, 190, 600 and 890 nM for BMK1, DCAMKL2, PLK4 and TNK1 respectively ; displays selectivity over 402 diverse kinases. |
abs810737 |
Fulvestrant |
10mg,100mg |
靶点: ERR |
Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.094 nM. |
abs814771 |
PHTPP |
10mg,100mg |
靶点: ERR |
PHTPP is an ERβ selective antagonist with 36-fold selective for ER βover ERα. |
abs815896 |
Tamoxifen |
100mg,200mg,500mg,1g |
靶点: ERR |
Tamoxifen is an antagonist of the estrogen receptor in breast tissue. |
abs812065 |
XCT790 |
5mg,10mg,50mg |
靶点: ERR |
XCT-790是雌激素相关受体(ERR)α反向激动剂,能诱导化疗抗性的癌细胞死亡。 |
abs810650 |
Rivaroxaban |
5mg,50mg,100mg |
靶点: Factor Xa |
Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. |
abs813072 |
Ferrostatin-1 |
5mg,10mg,25mg,50mg |
靶点: Ferroptosis |
Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂,EC50为60 nM。 |
abs810754 |
Liproxstatin-1 |
5mg,10mg,50mg,100mg |
靶点: Ferroptosis |
Liproxstatin-1 is able to suppress ferroptosis in cells, in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage. |
abs816204 |
RSL3 |
5mg,25mg |
靶点: Ferroptosis |
RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis. |
abs812189 |
PD173074 |
5mg,10mg,50mg,100mg |
靶点: FGFR |
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. |
abs817015 |
Luteolin |
10mg,50mg,100mg |
靶点: Flavonoids |
Luteolin is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentrated on the direct and indirect actions of flavonoids on tumor cells, and has found a variety of anticancer effects such as cell growth and kinase activity inhibition, apoptosis induction, suppression of the secretion of matrix metalloproteinases and of tumor invasive behavior. Furthermore, some studies have reported the impairment of in vivo angiogenesis by dietary flavonoids. Experimental animal studies indicate that certain dietary flavonoids possess antitumoral activity. |
abs813419 |
Pamidronate disodium salt |
25mg,100mg,200mg |
靶点: FPPS;HAP |
Pamidronate Disodium是一种含氮的双磷酸盐类药物,用于预防骨质疏松症。 |
abs812162 |
GW4064 |
5mg,10mg,50mg |
靶点: FXR |
GW4064是一种farnesoid X receptor (FXR)激动剂,CV1细胞系中EC50为65 nM。 |
abs810675 |
INT-747(Obeticholic acid) |
10mg,100mg |
靶点: FXR |
INT-747(Obeticholic acid; 6-ECDCA) is a potent and selective FXR agonist(EC50=99 nM) endowed with anticholestatic activity. |
abs812832 |
(+)-Bicuculline |
50mg,250mg,1g |
靶点: GABA Receptor |
(+)-Bicuculline is an antagonist of the GABAA receptor. (+)-Bicuculline is the parent compound of the water soluble N-methyl derivatives (-)-Bicuculline methiodide and (-)-Bicuculline methobromide . Antagonism of the GABAA receptor by (+)-Bicuculline blocks the neurotransmission inhibition function of the GABA system in vitro. |
abs817800 |
(R)-baclofen |
5mg,10mg,25mg,50mg |
靶点: GABA Receptor |
(R)-baclofena, a derivative of gamma-aminobutyric acid,is commonly utilized for the treatment of spasticity. |
abs817028 |
Baclofen |
50mg,100mg,200mg,500mg |
靶点: GABA Receptor |
Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission. |
abs813509 |
Bemegride |
50mg,100mg,200mg |
靶点: GABA Receptor |
Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning. |
abs821861 |
OTX008 |
5mg,25mg |
靶点: Galectin |
OTX008 is a selective inhibitor of galectin-1. |
abs812022 |
GANT61 |
5mg,10mg,50mg |
靶点: Gli |
GANT61是一种GLI1及GLI2诱导的转录抑制剂,抑制hedgehog,在表达GLI1的HEK293T细胞中IC50为5 μM,选择性作用于其他通路,如TNF和糖皮质激素受体基因的转录。 |
abs811907 |
Hydrocortisone |
25mg,200mg |
靶点: Glucocorticoid Receptor |
Hydrocortisone, a glucocorticoid receptor agonist, promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. Therapeutic Hydrocortisone is a synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. |
abs814165 |
GPR120 Compound A |
10mg,25mg |
靶点: GPR120 |
GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 μm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1). |
abs810578 |
AR-A014418 |
5mg,10mg,50mg,100mg |
靶点: GSK-3 |
AR-A014418 is a selective and effective GSK3β inhibitor with an IC 50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases. |
abs810052 |
CHIR-99021 (CT99021) |
5mg,25mg |
靶点: GSK-3 |
CHIR-99021 is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
abs818358 |
CHIR-99021 (CT99021) HCl |
2mg,5mg |
靶点: GSK-3 |
CHIR-99021 monohydrochloride is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
abs810638 |
IM-12 |
5mg,10mg,50mg,100mg |
靶点: GSK-3 |
The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling. |
abs810674 |
Kenpaullone |
5mg,50mg |
靶点: GSK-3 |
Kenpaullone is an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β). |
abs810372 |
LY2090314 |
5mg,10mg,50mg,100mg |
靶点: GSK-3 |
LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively. |
abs817887 |
SB216763 |
5mg,10mg,50mg |
靶点: GSK-3 |
SB216763是一种有效的,选择性GSK-3α抑制剂,IC50为34.3 nM,对GSK-3β具有同样的抑制作用。 |
abs810710 |
TWS119 |
5mg,10mg,50mg,100mg |
靶点: GSK-3 |
TWS119 is a GSK-3β inhibitor with IC50 of 30 nM. |
abs816302 |
Divalproex Sodium |
25mg,50mg,100mg |
靶点: HDAC |
Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. In rare cases, it is also used as a treatment for major depressive disorder, and increasingly taken long-term for prevention of both manic and depressive phases of bipolar disorder, especially the rapid-cycling variant. It is also used in the US for the treatment of epilepsy, chronic pain associated with neuropathy, and migraine headaches. Its chemical name is sodium hydrogen bis (2-propylpentanoate). The extended release formulation allows for a single daily dose. |
abs812019 |
Entinostat (MS-275, SNDX-275) |
10mg,100mg |
靶点: HDAC |
Entinostat (MS-275)强烈抑制HDAC1和HDAC3,无细胞试验中IC50分别为0.51 μM和1.7 μM,抑制作用强于HDACs 4, 6, 8,和10。 |
abs810414 |
LBH-589(Panobinostat) |
5mg,50mg |
靶点: HDAC |
Panobinostat(LBH-589) is a broad-spectrum HDAC inhibitor; low nanomolar concentrations (IC50=5-20 nM) of LBH589 induced cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8) hyperacetylation in MOLT-4 and Reh cell. |
abs810329 |
MC1568 |
5mg,50mg |
靶点: HDAC |
MC1568 is a class II (IIa) HDAC inhibitor selective for HDAC4 and HDAC6. |
abs812203 |
Rocilinostat (ACY-1215) |
5mg,10mg,50mg |
靶点: HDAC |
Rocilinostat (ACY-1215)是一种选择性HDAC6抑制剂,无细胞试验中IC50为5 nM,作用于HDAC6比作用于HDAC1/2/3(I型HDACs)选择性高10倍以上,对HDAC8具有微弱的作用活性,对HDAC4/5/7/9/11, Sirtuin1和Sirtuin2具有最小的作用活性。 |
abs812936 |
TMP269 |
2mg,5mg,10mg,25mg |
靶点: HDAC |
TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. |
abs817876 |
Trichostatin A (TSA) |
2mg,5mg,10mg |
靶点: HDAC |
Trichostatin A (TSA)是一种HDAC抑制剂,IC50为1.8 nM左右,HDAC8是HDAC家族中唯一不受TSA影响的成员。 |
abs812857 |
Vorinostat (SAHA) |
5mg,250mg |
靶点: HDAC;Mitophagy;Autophagy |
Vorinostat (SAHA) is an HDAC1/3 inhibitor with IC50 of ~10 nM. |
abs812230 |
Vismodegib(GDC0449) |
5mg,10mg,50mg,200mg |
靶点: Hedgehog;Autophagy |
Vismodegib (GDC0449)是一种新型有效的,特异性hedgehog抑制剂,无细胞试验中IC50为3 nM,也会抑制P-gp,IC50为3.0μM。 |
abs817881 |
2-Methoxyestradiol |
10mg,20mg,50mg,100mg |
靶点: HIF |
2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. |
abs810172 |
Dimethyloxaloylglycine(DMOG) |
25mg,50mg,100mg,200mg |
靶点: HIF |
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor). |
abs810656 |
FG-4592 |
5mg,50mg |
靶点: HIF |
FG-4592 is an HIF αprolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production. Phase 2/3. |
abs810573 |
IOX2 |
5mg,10mg,50mg,100mg |
靶点: HIF |
IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). IOX 2 displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases. |
abs812890 |
LW6 |
1mg,5mg,10mg,25mg |
靶点: HIF |
LW6是hypoxia-inducible factor 1(HIF)抑制剂。在缺氧环境下,LW6能通过降解HIF-1α,从而有效地抑制HIF-1α的积累,不影响HIF-1α mRNA水平。在cell-based HRE-reporter gene assays中,LW6抑制缺氧诱导的HIF-1α转录活性的IC50为2.64 μM。 |
abs817539 |
C646 |
5mg,10mg,25mg,50mg |
靶点: Histone Acetyltransferase |
C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases. |
abs821482 |
WM-8014 |
1mg,5mg |
靶点: Histone Acetyltransferase |
WM-8014 is an inhibitor of MOZ, a member of histone acetyltransferases, with an IC50 of 55 nM. |
abs814357 |
AS-8351 |
50mg,100mg |
靶点: Histone Demethylase |
AS 8351 induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409. |
abs810698 |
BIX-01294 |
5mg,50mg |
靶点: Histone Methyltransferase |
BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM. |
abs810322 |
GSK-126 |
5mg,10mg,50mg,100mg |
靶点: Histone Methyltransferase |
GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase with Ki value of 0.5 nM. |
abs817602 |
MI-2 (Menin-MLL Inhibitor) |
2mg,5mg,10mg,25mg |
靶点: Histone Methyltransferase |
MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. |
abs813376 |
Lopinavir |
50mg,200mg,1g |
靶点: HIV Protease |
Lopinavir是一种有效的HIV protease(HIV蛋白酶)抑制剂, Ki为1.3 pM。Lopinavir与突变型 HIV 蛋白酶(V82A, V82F 和 V82T)结合,Ki分别为4.9 pM, 3.7 pM和 3.6 pM。0.5 nM Lopinavir抑制93%野生型HIV蛋白酶活性。Lopinavir作用于MT4细胞,在有或无50% HS存在时,Lopinavir抑制HIV蛋白酶活性,EC50 分别为 102 nM 和17 nM。 |
abs813725 |
Mevastatin |
20mg,50mg,100mg,200mg |
靶点: HMGCR |
Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
abs817897 |
Simvastatin |
25mg,50mg,100mg,200mg |
靶点: HMGCR |
Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. |
abs810017 |
17-AAG |
5mg,10mg,25mg,50mg,100mg |
靶点: HSP |
Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。 |
abs811156 |
MKT 077 |
5mg,10mg,100mg |
靶点: HSP |
Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. |
abs817352 |
ADP |
10mg,50mg,100mg,500mg |
靶点: Human Endogenous Metabolite |
Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
abs816805 |
Uric Acid |
100mg,500mg |
靶点: Human Endogenous Metabolite |
An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN. |
abs811206 |
Birinapant (TL32711) |
5mg,10mg,50mg |
靶点: IAP |
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. |
abs810825 |
GDC-0152 |
10mg |
靶点: IAP |
GDC-0152 is a potent inhibitor of IAPs; binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with K(i) values of 28, 14, 17, and 43 nM, respectively. |
abs810180 |
Epacadostat (INCB024360) |
5mg,50mg |
靶点: IDO |
Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. Phase 2. |
abs810553 |
NLG-919 |
5mg,10mg,50mg,100mg |
靶点: IDO |
NLG-919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. |
abs812837 |
D-AP5 |
1mg,10mg |
靶点: iGluR |
D-AP5 is a selective antagonist of the NMDA receptor. D(-)-2-Amino-5-phosphonovaleric acid is described to antagonize amino acid-induced synaptic excitations, blocking L-aspartate and dorsal root-evoked spinal neuron excitation, without affecting cholinergic excitation induced by exogenous acetylcholine administration. Evoked electrical activity of neurons is suppressed by D(-)-2-Amino-5-phosphonovaleric acid antagonism of motoneuronal depolarizations at the NMDAR. The (+)-stereoisomer of D(-)-2-Amino-5-phosphonovaleric acid demonstrates considerably diminished NMDAR activity as compared to this (-)-isomer. |
abs810013 |
Bay 11-7082 |
5mg,10mg,25mg |
靶点: IKK |
BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system. |
abs812008 |
BAY11-7085 |
10mg,25mg |
靶点: IKK |
BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
abs812134 |
BMS-345541 |
5mg,25mg |
靶点: IKK |
BMS-345541是一种催化亚基的高选择性抑制剂,作用于IKK-2和IKK-1,无细胞试验中IC50分别为0.3 μM和4 μM。 |
abs811226 |
IKK-16 |
10mg,50mg,100mg |
靶点: IKK |
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
abs812057 |
TPCA-1 |
5mg,10mg,25mg |
靶点: IKK |
TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1.。 |
abs812858 |
Dexamethasone |
50mg,100mg |
靶点: IL Receptor |
Dexamethasone (DHAP)是一种有效的半合成的糖皮质激素类甾体药物,也是一种interleukin receptor调节剂,具有抗炎和免疫抑制作用。 |
abs816504 |
Arbidol hydrochloride |
5mg,10mg,50mg,100mg,1g |
靶点: Influenza Virus |
Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane. |
abs810092 |
CWHM-12 |
5mg,10mg,50mg,100mg |
靶点: Integrin |
CWHM-12 a novel small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8; less potency on αvβ5(IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1. |
abs810192 |
cyclo(-RGDfK) |
5mg,10mg,50mg,100mg |
靶点: Integrin |
cyclo(-RGDfK,-Arg-Gly-Asp-D-Phe-Lys)) is a selective αvβ3-integrin antagonist. |
abs810712 |
Tirofiban |
5mg,50mg |
靶点: Integrin |
Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist. |
abs810404 |
Baricitinib |
5mg,10mg,50mg,100mg |
靶点: JAK |
Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Phase 3. |
abs810416 |
Filgotinib (GLPG0634) |
5mg,10mg,50mg,100mg |
靶点: JAK |
GPLG0634 is a novel inhibitor of JAK1 and JAK2 with IC50 of 10nM and 28nM respectively. |
abs810565 |
Momelotinib (CYT387,CYT-387) |
5mg,10mg,50mg,100mg |
靶点: JAK |
CYT387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 11 nM and 18 nM, respectively. |
abs817700 |
Pyridone 6 |
2mg,10mg,25mg |
靶点: JAK |
Pyridone 6(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases. |
abs810523 |
Ruxolitinib |
5mg,10mg,50mg,100mg,500mg |
靶点: JAK |
Ruxolitinib is a potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively and is relatively less selective for JAK3 (IC50 = 322 nM). |
abs812831 |
Ruxolitinib phosphate |
5mg,50mg |
靶点: JAK |
Ruxolitinib phosphate(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. |
abs812216 |
TG101348(SAR302503) |
5mg,10mg,25mg,50mg |
靶点: JAK |
Fedratinib (SAR302503, TG101348)是一种选择性JAK2抑制剂,在无细胞试验中IC50为3 nM,作用于JAK2比作用于JAK1和JAK3选择性高35和334倍。 |
abs812960 |
Tofacitinib(CP 690550) |
5mg,10mg,25mg,50mg,1g |
靶点: JAK |
Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1. |
abs810295 |
wp1066(STAT Inhibitor III) |
5mg,10mg,50mg,100mg |
靶点: JAK |
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT. |
abs817944 |
Anisomycin |
10mg,50mg,100mg |
靶点: JNK |
Anisomycin是一种吡咯烷抗生素, 抑制蛋白质合成, 也是有效的SAPKs/JNKs激活剂。 |
abs810008 |
SP600125 |
10mg,50mg |
靶点: JNK;Autophagy |
SP600125是一种广谱JNK抑制剂,作用于JNK1,JNK2和JNK3,无细胞试验中IC50分别为40nM,40nM和90nM,比作用于MKK4选择性高10倍,比作用于MKK3,MKK6,PKB,和PKCα选择性高25倍,比作用于ERK2,p38,Chk1,EGFR等选择性高100倍。 |
abs818331 |
JPH203 |
5mg,25mg |
靶点: LAT1 |
JPH203 is a potent and selective L-type amino acid transporter 1 (LAT-1) inhibitor. |
abs812002 |
Fingolimod hydrochloride |
100mg,200mg |
靶点: LPL Receptor;PAK |
Fingolimod (FTY720) HCl是一种S1P拮抗剂,在K562 和 NK细胞中IC50为0.33 nM。 |
abs810297 |
LRRK2-IN-1 |
10mg,50mg,100mg |
靶点: LRRK2 |
LRRK2-IN-1 inhibits both wild-type and G2019S mutant LRRK2 kinase activity with IC50 values of 13 nM and 6 nM , respectively with 0.1 mM ATP in the assay. |
abs813423 |
Levetiracetam |
25mg,50mg,100mg,200mg |
靶点: mAChR |
Levetiracetam是一种抗癫痫化合物。 |
abs816579 |
Methscopolamine bromide |
25mg,50mg,100mg,200mg |
靶点: mAChR |
Methscopolamine (Pamine), as a natural plant alkaloid, is a muscarinic acetylcholine receptor blocker. |
abs813783 |
Pilocarpine hydrochloride |
100mg,200mg,500mg |
靶点: mAChR |
Pilocarpine hydrochloride is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. |
abs816974 |
Corticosterone |
2mg,5mg,10mg,25mg |
靶点: MAT |
Corticosterone is a sensitive inhibitor of monoamine transport. |
abs812182 |
NUTLIN 3 |
5mg,10mg,25mg,100mg |
靶点: MDM2 |
Nutlin-3是一种有效的,选择性Mdm2(它自身和p53的环指依赖性泛素蛋白连接酶)拮抗剂,无细胞试验中IC50为90 nM;可稳定p53缺陷细胞中的p73。 |
abs813165 |
Nutlin-3a |
5mg,10mg,100mg |
靶点: MDM2 |
Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM. |
abs813183 |
AZD8330 |
5mg,10mg,50mg |
靶点: MEK |
AZD8330是一种新型,选择性的,非ATP竞争性MEK 1/2抑制剂,IC50为7 nM。AZD8330可以有效抑制MEK 1/2。在pERK系统中AZD8330能达到超豪微摩尔级的效力,在MEK 1/2抑制剂敏感的细胞系的功能(扩增)实验中也能达到低至超豪微摩尔级的效力。MEK抑制剂AZD8330特异性抑制促分裂原活化蛋白激酶激酶1(MEK 或 MAP/ERK激酶1),抑制了生长因子调节的细胞信号传导的过程并抑制了肿瘤细胞增殖。 |
abs813214 |
Binimetinib |
5mg,10mg,50mg,100mg |
靶点: MEK |
Binimetinib是一种有效的MEK1/2抑制剂,IC50为12 nM。ARRY-438162(625 nM)抑制体外破骨细胞分化,IC50为39 nM。ARRY-438162(10 μM)抑制体外破骨细胞再吸收,IC50为625 nM。ARRY-438162(2 μM)微弱影响成骨细胞分化。 |
abs810381 |
BIX02188 |
5mg,50mg |
靶点: MEK |
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
abs810764 |
Cobimetinib |
2mg,5mg,10mg,50mg |
靶点: MEK |
GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase, also known as MEK, a serine/threonine kinase that is a component of the RAS/RAF/MEK/ERK pathway. |
abs810010 |
PD 98059 |
5mg,10mg,50mg |
靶点: MEK |
PD98059是一种非ATP竞争性的MEK抑制剂,无细胞试验中IC50为2 μM,特异性抑制MEK-1介导的MAPK激活;不直接抑制ERK1或ERK2。PD98059不会抑制已经被c-Raf磷酸化的 MEK1。 |
abs810490 |
PD0325901 |
5mg,10mg,50mg,100mg |
靶点: MEK |
PD0325901 is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2. |
abs817537 |
PD184352 (CI-1040) |
5mg,10mg,25mg,50mg |
靶点: MEK |
PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2. |
abs810658 |
Trametinib (GSK1120212) |
5mg,10mg,50mg,100mg |
靶点: MEK |
Trametinib is a dual-kinase inhibitor that is used in the treatment of advanced malignant melanoma. Trametinib therapy is associated with transient elevations in serum aminotransferase and alkaline phosphatase levels during therapy, but has yet to be linked cases of clinically apparent acute liver injury. |
abs810003 |
U0126 |
5mg,10mg,25mg,50mg,100mg |
靶点: MEK |
U-0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor. |
abs810857 |
U0126-EtOH |
10mg,100mg |
靶点: MEK |
U0126-EtOH(U-0126) is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059. |
abs813011 |
CHPG Sodium salt |
10mg,50mg |
靶点: mGluR |
CHPG Sodium salt is the more aqueous soluble version of the selective mGluR agonist CHPG , which has been shown to be inactive at mGluR-1a which is expressed in CHO cells. |
abs814359 |
FITM |
2mg,5mg |
靶点: mGluR |
FITM is a nove mGlu1 inhibitor. FITM shows high affinity (Ki = 2.5 nM, fig. S2) and selectivity for mGlu1 over mGlu5. |
abs812847 |
L-AP4 |
1mg,10mg |
靶点: mGluR |
Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. |
abs810222 |
MPEP hydrochloride |
5mg,10mg,50mg,100mg |
靶点: mGluR |
MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM. |
abs813885 |
VU 0364770 |
5mg,10mg,50mg,250mg |
靶点: mGluR |
VU 0364770是一种mGlu4正变构调节剂(PAM),EC50为1.1 μM,对68种其他受体,包括其他mGlu亚型,几乎没有作用活性。VU0364770是一种强有效的代谢型谷氨酸受体4 (mGlu4)正向别构调节剂。在含有EC20浓度谷氨酸盐情况下1.1 μM的VU0346770 对人源mGlu4效能可以使谷氨酸盐浓度响应曲线向左移动31.4倍。290 nM的 VU0364770对大鼠mGlu4具有效能并诱导谷氨酸盐浓度响应曲线向左移动18.1 倍。 |
abs820868 |
Cytochalasin B |
1mg |
靶点: Microtubule/Tubulin |
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin. |
abs810739 |
Docetaxel |
5mg,25mg,100mg |
靶点: Microtubule/Tubulin |
Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
abs816143 |
Docetaxel Trihydrate |
25mg,50mg,100mg,200mg |
靶点: Microtubule/Tubulin |
Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
abs817886 |
Nocodazole |
10mg,50mg,100mg |
靶点: Microtubule/Tubulin |
Nocodazole是一种微管聚合的快速可逆抑制剂,也抑制Abl, Abl(E255K)和Abl(T315I),IC50分别为0.21 μM, 0.53 μM和0.64 μM。 |
abs810020 |
Paclitaxel |
5mg,10mg,25mg,50mg,100mg |
靶点: Microtubule/Tubulin |
Paclitaxel (紫杉醇) 是微管聚合稳定剂,IC50是0.1 pM。Paclitaxel 是有丝分裂抑制剂。 |
abs812886 |
Amphotericin B |
50mg,100mg |
靶点: Miscellaneous |
Amphotericin B 是一种两亲的多烯类抗生素,能够使含有麦角固醇的细胞膜渗透化。 |
abs816057 |
i-Inositol |
100mg,500mg |
靶点: Miscellaneous |
i-Inositol, also known as myo-inositol, is a chemical compound which is sugar alcohol. i-Inositol is involved in a number of biological processes including insulin signal transduction, cytoskeleton transduction and so on. |
abs814575 |
Palmitic Acid |
25mg,100mg |
靶点: Miscellaneous |
Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity. |
abs814596 |
Hemin |
100mg,500mg |
靶点: Mitophagy;Autophagy |
Hemin is an iron-containing porphyrin used in the management of porphyria attacks, particularly in acute intermittent porphyria. |
abs810002 |
SB 203580 |
5mg,10mg,100mg |
靶点: Mitophagy;p38 MAPK;Autophagy |
SB203580是一种p38 MAPK抑制剂,在THP-1细胞中IC50为0.3-0.5μM,对SAPK3(106T)和SAPK4(106T)选择性低10倍,且阻断PKB磷酸化,IC50为3-5μM。SB203580是第一个被报道的p38抑制剂。 |
abs814352 |
Necrosulfonamide (NSA) |
50mg |
靶点: MLKL |
Necrosulfonamide (NSA) is a very specific and potent necrosis inhibitor with an IC50 less than 0.2 uM. |
abs817933 |
GM6001 |
2mg,5mg,10mg,50mg |
靶点: MMP |
GM6001 (galardin, ilomastat)是泛MMP抑制剂,对MMP-1,MMP-2,MMP-3,MMP-7,MMP-8,MMP-9,MMP-12,MMP-14和MMP-26的Ki为0.4-27 nM。 |
abs810260 |
T-5224 |
5mg,50mg |
靶点: MMP |
T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1, attenuates lipopolysaccharide-induced liver injury in mice. |
abs818298 |
XMU-MP-1 |
2mg,5mg,10mg |
靶点: MST |
XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50 values of 71.1 and 38.1 nM against MST1 and MST2. |
abs812994 |
Glycine |
25mg,100mg |
靶点: MT Receptor |
Glycine is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. |
abs812897 |
Melatonin |
100mg,500mg,1g |
靶点: MT Receptor |
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant. |
abs813441 |
AZD2014 |
5mg,10mg,50mg,100mg |
靶点: mTOR |
AZD2014是一种新型mTOR抑制剂,IC50为2.8 nM;高选择性作用于多种PI3K亚型(α/β/γ/δ)。AZD2014 是AZD8055的类似物,是mTOR 激酶的选择性抑制剂。与Rapamycin相比,AZD2014 更有效抑制mTORC1: AZD2014 降低 p4EBP1 Thr37/46, 抑制翻译起始复合体,和降低全部蛋白合成,而Rapamycin没有这些效果。AZD2014 也抑制mTORC2生物标记pAKTSer473和 pNDRG1Thr346。 |
abs810772 |
AZD-8055 |
10mg,50mg,100mg |
靶点: mTOR |
AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. |
abs810396 |
Everolimus |
5mg,10mg,50mg,100mg |
靶点: mTOR |
Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
abs810040 |
FK-506 |
5mg,10mg,25mg,100mg |
靶点: mTOR |
Tacrolimus (FK506) 是一种23元大环内酯物,通过结合到抑免蛋白 FKBP12 (FK506结合蛋白) 产生新的复合物,从而降低T细胞中肽酰脯氨酰异构酶活性。FK-506和环孢霉素A阻断细胞质成分的移位,而不影响T淋巴细胞中核亚基的合成。FK-506通过抑制需要白细胞介素-2转录诱导的Ca(2+)-依赖过程,阻止T细胞增殖。FK-506结合于不同的细胞内蛋白质(免疫亲和素)家族,学术上称为亲环素类和FK 506结合蛋白(FKBPs)。FK-506特异性抑制细胞内磷酸酶,在药物浓度下,抑制活化的T细胞中白介素2的产生。FK-506和CsA通过抑制早期钙相关的涉及淋巴因子表达,凋亡,和脱粒作用,在细胞中几乎发挥相同的生物学作用。FK-506与细胞内受体家族结合,学术上称为FK-506结合蛋白(FKBPs)。 |
abs810344 |
INK-128 |
5mg,10mg,50mg,100mg |
靶点: mTOR |
INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM; >200-fold less potent to class I PI3K isoforms. |
abs812032 |
KU-0063794 |
5mg,10mg,25mg,50mg |
靶点: mTOR |
KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks. |
abs810289 |
MHY1485 |
5mg,10mg,50mg,100mg |
靶点: mTOR |
MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. |
abs820227 |
MSDC-0602 |
5mg,25mg,500mg,1g |
靶点: mTOR |
MSDC-0602, a PPARγ-sparing thiazolidinedione (TZD), interacts with the mitochondrial pyruvate carrier (MPC) and inhibits its activity and are effective for treatment of type 2 diabetes with reducing risk of PPARγ-mediated side effects. |
abs812186 |
OSI027 |
5mg,10mg,50mg |
靶点: mTOR |
OSI027是一种选择性的有效的双重mTORC1和mTORC2抑制剂,无细胞试验中IC50分别为22 nM 和 65 nM,作用于mTOR的选择性比作用于PI3Kα,PI3Kβ,PI3Kγ或 DNA-PK高100多倍。 |
abs810030 |
Rapamycin |
5mg,10mg,100mg |
靶点: mTOR |
Rapamycin (Sirolimus)是一种特定的 mTOR 抑制剂,在 HEK293细胞中,IC50 为 ~0.1nM。 Rapamycin作用于HEK293细胞,抑制内源性mTOR活性,IC50为~0.1nM,而iRap和AP21967 作用时,IC50分别为~5 nM 和~10 nM。Rapamycin处理酿酒酵母,诱导细胞周期停在G1/S期,且抑制翻译。Rapamycin显著抑制T98G和U87-MG细胞活力,这种作用具有剂量依赖性,IC50分别为2nM和1μM,而对U373-MG细胞没有作用活性,IC50>25μM。Rapamycin(100 nM) 作用于对Rapamycin敏感的U87-MG和T98G细胞,通过抑制mTOR功能,而诱导细胞周期停在G1期,也诱导自噬而不是凋亡。 在体内,Rapamycin 处理,特定阻断mTOR下游靶点,如p70S6K磷酸化和激活,和PHAS-1/4E-BP1导致的eIF4E抑制释放,完全阻断跖肌重量和纤维尺寸的肥厚增高。短期Rapamycin处理,即使按最低剂量0.16 mg/kg处理, 强抑制p70S6K活性, 与提高的肿瘤细胞死亡和Eker肾脏肿瘤坏死相关。Rapamycin作用于CT-26移植瘤模型,通过降低VEGF产量,及阻断VEGF诱导的内皮细胞信号,而抑制转移性肿瘤生长和血管新生。Rapamycin每天按4mg/kg剂量处理C6移植瘤,显著降低肿瘤生长,和肿瘤血管通透性。 |
abs813199 |
Ridaforolimus |
5mg,10mg,25mg,50mg |
靶点: mTOR |
Ridaforolimus (Deforolimus, MK-8669)是一种选择性的mTOR抑制剂,IC50为0.2 nM;对mTOR信号通路的抑制作用及与FKBP12结合能力和Rapamycin接近。使用Deforolimus处理HT-1080细胞,抑制S6和4E-BP1磷酸化, 这种作用存在剂量依赖性,IC50分别为0.2 nM和5.6 nM, EC50分别为0.2 nM 和1.0 nM, 且导致细胞尺寸降低,G1期细胞增多,和抑制葡萄糖摄取,EC50为0.1-1 nM。Deforolimus作用于一组细胞系,具有显著抗增殖活性,EC50为0.2-2.3 nM。Deforolimus 有效且选择性抑制VEGF产量,这种作用存在剂量依赖性, EC50为~0.1 nM。 |
abs812924 |
Torin2 |
2mg,5mg,10mg,25mg |
靶点: mTOR |
Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively. |
abs812923 |
Torin-1 |
5mg,20mg,50mg |
靶点: mTOR;Autophagy |
Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM; exhibits 1000-fold selectivity for mTOR than PI3K. |
abs819572 |
Apocynin |
1g,5g |
靶点: NADPH Oxidase |
Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
abs810175 |
GKT137831 |
5mg |
靶点: NADPH Oxidase |
GKT137831 is a novel and specific dual Nox1/Nox4 inhibitor with Ki of 140±40 nM and 110±30 nM; a potent inhibitor of fibrosis and hepatocyte apoptosis. |
abs812157 |
FK866 |
5mg,10mg,25mg,50mg |
靶点: NAMPT |
FK866 (APO866, Daporinad)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase),无细胞试验中IC50为0.09 nM。 |
abs810606 |
S0859 |
5mg,10mg,50mg,100mg |
靶点: NBC |
S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
abs814191 |
AHU-377 hemicalcium salt |
50mg,100mg,1g |
靶点: Neprilysin |
AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM. |
abs813925 |
Oseltamivir phosphate |
100mg,200mg,500mg |
靶点: Neuraminidase |
Oseltamivir phosphate (Tamiflu) is a competitive neuraminidase inhibitor. The prodrug oseltamivir phosphate (Tamiflu) is itself not virally effective; however, once in the liver, it is converted by natural chemical processes, hydrolysed hepatically to its active metabolite, the free carboxylate of oseltamivir (GS4071). Oseltamivir phosphate (Tamiflu) serves as a competitive inhibitor towards sialic acid, found on the surface proteins of normal host cells. By blocking the activity of the viral neuraminidase enzyme, oseltamivir phosphate (Tamiflu) prevents new viral particles from being released by infected cells. Oseltamivir phosphate (Tamiflu) is an antiviral drug that slows the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell. |
abs812850 |
Substance P |
5mg,25mg |
靶点: Neurokinin Receptor |
Substance P 是一种神经肽,作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor,NK1R) |
abs810538 |
JSH-23 |
5mg,10mg,50mg,100mg |
靶点: NF-kB |
JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM. |
abs814766 |
Pyrrolidinedithiocarbamate ammonium |
100mg,500mg |
靶点: NF-kB |
Pyrrolidinedithiocarbamate ammonium, a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction. |
abs810745 |
QNZ |
5mg,50mg |
靶点: NF-kB |
QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively. |
abs811516 |
SC75741 |
10mg,50mg |
靶点: NF-kB |
SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. |
abs810111 |
MCC-950 sodium |
5mg,10mg,50mg,100mg |
靶点: NLR |
MCC950 (CP-456773) sodium is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs. |
abs810778 |
(-)-MK 801 maleate |
10mg,50mg,1g |
靶点: NMDAR |
(-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist . |
abs810777 |
(+)MK-801 maleate |
10mg,100mg,1g |
靶点: NMDAR |
Dizocilpine maleate(MK 801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM |
abs813680 |
Ifenprodil Tartrate |
10mg,25mg,50mg,100mg,200mg |
靶点: NMDAR;Potassium Channel;iGluR |
Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM. |
abs817782 |
ML130 (Nodinitib-1) |
10mg,50mg |
靶点: NOD |
ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. |
abs817904 |
L-NAME HCl |
100mg,500mg |
靶点: NOS |
L-NAME盐酸盐是一种细胞渗透性的NO合成酶抑制剂, 作用于nNOS (牛), eNOS (人), 和 iNOS (鼠)时, Ki值分别为 15 nM, 39 nM, 和 4.4 μM。 |
abs811411 |
FLI-06 |
10mg,50mg,100mg |
靶点: Notch |
FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. |
abs814799 |
tert-Butylhydroquinone |
1g,5g |
靶点: Nrf2 |
Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2. |
abs821242 |
Remdesivir |
5mg,50mg,1g |
靶点: NRTI |
Remdesivir (GS-5734) is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. |
abs813494 |
8-Azaguanine |
25mg,50mg,100mg |
靶点: Nucleoside Antimetabolite/Analog |
Azaguanine-8 is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism. 8-Azaguanine is a purine analogue that shows antineoplastic activity. Azaguanine-8 functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, so that it can inhibite cellular growth. Azaguanine-8 has been reported that a study of the in vivo metabolism of 8-azaguanine-2-C 14 by mouse neoplasms that are susceptible or resistant to growth inhibition by 8-azagnanine. The results show that the growth of those neoplasms which convert significant amounts of 8-azaguanine to 8-azaguanylic acid is inhibited by 8-azaguanine. |
abs811263 |
Arbidol |
5mg,10mg,50mg |
靶点: Others |
Arbidol is a Russian-made potent broad-spectrum antiviral with demonstrated activity against a number of enveloped and non-enveloped viruses. |
abs815864 |
Oxytocin (Syntocinon) |
25mg,100mg |
靶点: OXTR |
Oxytocin(Syntocinon) is a nine amino acid peptide that is synthesized in hypothalamic neurons and transported down axons of the posterior pituitary for secretion into blood. |
abs812031 |
KN-62 |
5mg,10mg,50mg |
靶点: P2X Receptor |
KN-62是可渗透入细胞的CaM激酶II抑制剂,IC50为0.9 μM,直接与该酶的钙调蛋白结合位点结合,同时还是非竞争性P2X7受体拮抗剂,IC50为15 nM。 |
abs817419 |
Suramin Sodium Salt |
25mg |
靶点: P2Y Receptor |
Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM). |
abs812131 |
BIRB 796 (Doramapimod) |
5mg,10mg,50mg,100mg |
靶点: p38 MAPK |
BIRB 796 (Doramapimod)是一种泛p38 MAPK抑制剂,在无细胞试验中作用于p38α/β/γ/δ的IC50分别为38 nM,65 nM,200 nM 和520 nM,并且能够与p38α结合,在THP-1细胞中Kd为0.1 nM,比作用于JNK2选择性高330倍,对c-RAF,Fyn 和Lck具有较弱的抑制作用,对ERK-1,SYK,IKK2也有微弱抑制作用。 |
abs812172 |
LY2228820 |
5mg,10mg,50mg |
靶点: p38 MAPK |
LY2228820是一种新型有效的p38 MAPK抑制剂,无细胞试验中IC50为7 nM,不改变p38 MAPK的活化。 |
abs812866 |
SB 203580 hydrochloride |
10mg,25mg,100mg |
靶点: p38 MAPK |
SB 203580 hydrochloride is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM. |
abs810009 |
SB202190 (FHPI) |
5mg,50mg |
靶点: p38 MAPK |
SB202190(FHPI)是一种有效的p38MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。 |
abs815903 |
Ketoconazole |
25mg,50mg,100mg,500mg |
靶点: P450 |
Ketoconazole inhibits <b>cyclosporine oxidase</b> and <b>testosterone 6 beta-hydroxylase</b> with <b>IC50</b> of 0.19 mM and 0.22 mM, respectively. |
abs814549 |
Baicalein |
50mg,100mg,200mg |
靶点: P450 |
Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. |
abs813510 |
Benzbromarone |
25mg,50mg,100mg,200mg,1g |
靶点: P450 |
Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout. |
abs816243 |
Memantine hydrochloride |
500mg,1g,5g |
靶点: P450 |
Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively. |
abs810579 |
JNJ26854165 |
5mg,10mg,50mg,100mg |
靶点: p53 |
JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. |
abs817620 |
Pifithrin-α |
5mg,10mg,25mg,50mg |
靶点: p53 |
Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. |
abs814321 |
Cl-amidine |
25mg,50mg |
靶点: PAD |
Cl-amidine is a cell-permeable compound that acts as a pan PAD inhibitor (IC50 = 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively) in enzymatic assays. |
abs813223 |
INO-1001 |
100mg,500mg |
靶点: PARP |
INO-1001是一种有效的PARP抑制剂,作用于CHO细胞的IC50为<50 nM,在再灌注期间,是一种因氧化诱导而发生的心肌功能障碍的调节剂。用浓度为0.05 到50 μM的INO-1001处理CHO细胞30分钟,明显抑制PARP 活性, IC50 为50 nM, INO-1001浓度为1 μM 或更高时抑制PARP活性达95%,且没有细胞毒性。此外, INO-1001通过阻断大部分受辐射的DNA片段修复而使CHO 细胞敏感。用400 μM H2O2处理后,通过增强乙酰胆碱诱导的, 依赖内皮细胞层的, NO调节的血管舒张,而提高INO-1001抑制PARP活性。 |
abs812037 |
Olaparib (AZD2281, KU0059436) |
5mg,10mg,50mg,100mg |
靶点: PARP |
Olaparib (AZD2281, Ku-0059436)是一种选择性的PARP1/2抑制剂,无细胞试验中IC50为5 nM/1 nM,比对Tankyrase-1的作用强300倍。 |
abs811902 |
GW 4869 |
5mg,25mg |
靶点: PDE |
A cell-permeable, symmetrical dihydroimidazolo-amide compound that acts as a potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase) [IC50 = ~ 1 µM, rat brain; Km for sphingomyelin ~13 µM]. Does not inhibit human A-SMase (acid sphingomyelinase) even at 150 µM. Weakly inhibits the activities of bovine protein phosphatase 2A and mammalian lyso-PAF PLC, while no inhibition is observed for bacterial phosphatidylcholine-specific PLC. Reported to offer complete protection against TNF-α or diamine-induced cell death in MCF7 breast Y cells at 20 µM. Does not modify the intracellular glutathione levels or interfere with TNF-α or diamine-mediated signaling effects. |
abs817348 |
IBMX |
25mg,100mg |
靶点: PDE |
3-Isobutyl-1-methylxanthine is a potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES |
abs819222 |
Pentoxifylline |
10mg,250mg,1g |
靶点: PDE |
Pentoxifylline是竞争性非选择性磷酸二酯酶(PDE)抑制剂。 |
abs816222 |
PF-8380 |
10mg,50mg,200mg |
靶点: PDE |
PF-8380 is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. |
abs817078 |
Sildenafil |
5mg,25mg,100mg,500mg |
靶点: PDE |
Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH. |
abs819476 |
Sunitinib |
100mg,500mg |
靶点: PDGFR |
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. |
abs810349 |
BX-795 |
5mg,10mg,50mg,100mg |
靶点: PDK-1 |
BX795 is a potent and selective dual inhibitor of TBK1/PDK1 with IC50s of 2 nM/6 nM respectively; > 50 fold selectivity over PKA, PKC, c-Kit, GSK3β etc. |
abs812199 |
PS48 |
5mg,10mg |
靶点: PDK-1 |
PS48是一小分子PDK1激动剂,Kd值为10.3uM,特异性结合PDK1的PIF-binding pocket,区别于ATP结合位点。 |
abs815928 |
Curcumin |
50mg,200mg |
靶点: Phenols |
Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB. |
abs815905 |
Resveratrol |
50mg,200mg,100mg |
靶点: Phenols |
Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. |
abs817676 |
Xanthoxyline |
10mg,50mg,250mg |
靶点: Phenols |
Derivatives of xanthoxyline have antispasmodic activity. |
abs817781 |
Caffeic Acid Phenethyl Ester |
50mg,200mg |
靶点: Phenylpropanoids |
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
abs812987 |
β-Glycerophosphate sodium salt hydrate |
1g,5g |
靶点: Phosphatase |
β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor. |
abs810836 |
ML-348(ML348) |
5mg,50mg |
靶点: Phospholipase |
ML 348(ML348) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). |
abs811072 |
BYL-719(Alpelisib) |
5mg,10mg,50mg |
靶点: PI3K |
BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. |
abs810586 |
NVP-BKM120(Buparlisib) |
5mg,50mg |
靶点: PI3K |
BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. |
abs812217 |
TGX221 |
5mg,25mg,100mg |
靶点: PI3K |
TGX-221 是一种p110β-特定的抑制剂,在无细胞试验中IC50为 5 nM,作用于p110β的选择性是作用于p110α的1000倍。 |
abs813440 |
AZD6482 |
5mg,10mg,25mg,50mg |
靶点: PI3K;Autophagy |
AZD6482是一种PI3Kβ抑制剂,IC50为10 nM,作用于PI3Kβ比作用于PI3Kδ, PI3Kα和PI3Kγ选择性分别高8,87和109倍。AZD6482是PI3Kβ抑制剂,IC50为21 nM, 然而, AZD6482也抑制PI3Kα,γ,和δ, IC50为 80 nM到1.4 μM, 明显比其(+)-对印异构体(S型)低很多。AZD6482是抗血小板药,在洗涤血小板聚集(WPA)实验中,抑制活化血小板粘附/聚集,且促进血小板解聚,IC50为6 nM。而且, AZD6482靶向作用于PI3Kβ,特定抑制血栓形成而不影响正常止血。 |
abs810397 |
Idelalisib (CAL-101) |
5mg,10mg,50mg,100mg |
靶点: PI3K;Autophagy |
CAL-101 is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ thanp110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. |
abs811026 |
ZSTK474 |
10mg,50mg,100mg |
靶点: PI3K;Autophagy |
ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. |
abs810001 |
LY 294002 |
10mg,25mg,100mg |
靶点: PI3K;DNA-PK;Autophagy |
LY294002 是首个合成的已知抑制PI3Kα/δ/β的小分子,在无细胞测定中IC50分别为 0.5μM/0.57 μM/0.97μM;在溶液中比在Wortmannin中稳定,也能够阻断自噬体的形成。LY294002是选择性的, 可渗透细胞的特定PI3K抑制剂,可作用于酶的ATP结合位点,且抑制自体吞噬的螯合作用。在体内,LY294002也抑制肿瘤生长和诱导凋亡,尤其作用于LoVo肿瘤, 因此作用于鼠癌性腹膜炎模型具有明显药效。 LY294002明显抑制卵巢癌生长和腹水形成。 |
abs812195 |
PI-103 |
5mg,10mg,25mg,50mg |
靶点: PI3K;DNA-PK;mTOR;Autophagy |
PI-103是一种多靶点 PI3K 抑制剂,在无细胞试验中作用于p110α/β/δ/γ的IC50为 2 nM/3 nM/3 nM/15 nM,对 mTOR/DNA-PK的作用较小,IC50为30 nM/23 nM。 |
abs810575 |
3-Methyladenine |
50mg,200mg,500mg |
靶点: PI3K;Endogenous Metabolite;Mitophagy;Autophagy |
3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM. |
abs813206 |
Apitolisib (GDC-0980, RG7422) |
5mg,10mg,50mg |
靶点: PI3K;mTOR |
Apitolisib (GDC-0980, RG7422)是一种有效的,I型PI3K抑制剂,作用于PI3Kα/β/δ/γ,IC50分别为5 nM/27 nM/7 nM/14 nM,也抑制mTOR,Ki为17 nM,高选择性作用于其他PIKK家族激酶。 |
abs814051 |
GSK1059615 |
5mg,10mg,50mg |
靶点: PI3K;mTOR |
GSK1059615是一种PI3Kα/β/δ/γ (可逆的)和mTOR的双重抑制剂,IC50分别为0.4 nM/0.6 nM/2 nM/5 nM和12 nM。GSK1059615也抑制mTOR,IC50为12 nM。GSK1059615抑制PI3K通路,诱导细胞停滞在G1期,可观察到凋亡。GSK1059615有效作用于胸腺癌细胞。 |
abs812111 |
BEZ235(NVP-BEZ235) |
25mg,50mg,100mg,200mg |
靶点: PI3K;mTOR;Autophagy |
BEZ235 (NVP-BEZ235, Dactolisib) 是一种双重ATP竞争性 PI3K 和 mTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。 |
abs810323 |
Omipalisib |
5mg,10mg,50mg,100mg |
靶点: PI3K;mTOR;Autophagy |
GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively. |
abs810616 |
AZD1208 |
5mg,10mg,50mg,100mg |
靶点: Pim |
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. |
abs812211 |
SGI-1776 |
5mg,10mg,50mg |
靶点: Pim |
SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1. |
abs810011 |
H-89 2HCl |
5mg,25mg,100mg |
靶点: PKA |
H892HCl是一种有效的PKA抑制剂,无细胞试验中Ki为48nM,作用于PKA比作用于PKG选择性高10倍,比作用于PKC,MLCK,钙调蛋白激酶II和酪蛋白激I/II选择性高500倍。 |
abs810006 |
Staurosporine |
5mg,25mg |
靶点: PKA;PKC |
Staurosporine是一种有效的PKC抑制剂,在无细胞试验中作用于PKCα,PKCγ 和PKCη,IC50分别为2nM,5nM 和 4nM,对PKCδ(20nM)和PKCε(73nM作用较弱,对PKCζ (1086nM)的活性很低。同时 对其他的激酶PKA,PKG,S6K,CaMKII,等也显示抑制活性。 |
abs810742 |
GO-6983 |
2mg,5mg,10mg,50mg |
靶点: PKC |
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ. |
abs811101 |
Sotrastaurin |
5mg,10mg,25mg,50mg |
靶点: PKC |
Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis. |
abs812129 |
BI2536 |
5mg,10mg |
靶点: PLK |
BI2536是Plk1抑制剂,IC50为0.83 nM,还能抑制BRD4,IC50为25 nM。 |
abs813204 |
GSK461364 |
5mg,10mg,20mg,50mg |
靶点: PLK |
GSK461364抑制纯化的Plk1,Ki为2 nM,比作用于Plk2/3选择性高1000倍。GSK461364作用于非细胞分裂细胞,从多起点抑制癌细胞系增殖。 野生型p53的RNA沉默提高GSK461364的抗增殖活性。许多癌症疗法对p53野生型患者更有效, p53缺陷肿瘤对GSK461364的高度敏感性可提供治疗肿瘤的机会。 |
abs813185 |
Volasertib (BI 6727) |
5mg,10mg,50mg |
靶点: PLK |
Volasertib (BI 6727)是一种高度有效的Plk1抑制剂,IC50为0.87 nM,比作用于Plk2和Plk3选择性高6和65倍。如同BI2536,BI6727是属于dihydropteridinone类化合物的ATP竞争性激酶抑制剂。除了Plk1,BI6727也有效地抑制两个密切相关的激酶Plk2和Plk3,IC50分别为为5 nM和56 nM。 BI6727在浓度高达10 μM时对五十多种激酶均没有抑制活性。 |
abs811224 |
LGK-974 |
5mg,10mg,50mg |
靶点: PORCN |
LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay. |
abs816511 |
Diazoxide |
25mg,50mg,100mg,200mg |
靶点: Potassium Channel |
Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. |
abs817310 |
Glyburide |
50mg,500mg |
靶点: Potassium Channel |
Glibenclamide(Glyburide) is a sulfonylurea compound that modulates insulin production. |
abs812222 |
TRAM-34 |
5mg,10mg,50mg |
靶点: Potassium Channel |
TRAM-34是中电导的钙激活的钾离子通道(KCa3.1),Kd为20 nM,不抑制细胞色素P450。 |
abs810411 |
GW-9662 |
5mg,50mg |
靶点: PPAR |
GW9662 is a selective PPAR antagonist, inhibiting PPARγ, PPARα and PPARδ with IC50 of 3.3 nM, 32 nM and 2 μM, respectively. |
abs814605 |
Troglitazone |
5mg,25mg |
靶点: PPAR |
Troglitazone is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. |
abs817916 |
Rosiglitazone |
10mg,50mg,100mg,200mg |
靶点: PPAR;TRP Channel;Autophagy |
Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rare instances of acute liver injury. |
abs816075 |
Desogestrel |
10mg,25mg,100mg |
靶点: Progesterone Receptor |
Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. |
abs813640 |
Ethynodiol diacetate |
100mg,500mg |
靶点: Progesterone Receptor |
Ethynodiol diacetate是第一批合成的避孕药用孕激素之一。去甲二氢愈创木酸(NDGA) (< 1.5 μM)在150 μg/mL ethynodiol diacetate处理的人淋巴细胞中可以降低姐妹染色单体的交换率(SCEs)。在S9混合物存在的情况下NDGA处理会减轻ethynodiol diacetate 引起的遗传毒性损伤,这可能是通过对细胞色素P450s的抑制实现的而P450s会阻止ethynodiol diacetate的代谢活化,也可能是由于 NDGA具有清除自由基的功能。在S9混合物存在的情况下, Ethynodiol diacetate (150 μg/mL)会增加人淋巴细胞中姐妹染色单体的交换率(SCEs)和染色体畸变(CAs)频率并能 抑制淋巴细胞增殖。 |
abs817907 |
Mifepristone |
50mg,100mg,200mg,500mg |
靶点: Progesterone Receptor |
Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist. |
abs818385 |
CJ-42794 |
10mg,50mg |
靶点: Prostaglandin Receptor |
CJ-42794, as a selective antagonist of EP4, less binds to EP2 and does not have binding affinity for EP1 or EP3. It displays minimal effect on numerous other receptors, channels, or enzymes. CJ-42794 delays the healing of gastric ulcers, inhibiting the upregulation of VEGF expression and angiogenesis. EP4, activated by prostaglandin E2 (PGE2), is a G-protein-coupled receptor, which plays vital roles in bone formation and resorption, cancer, and atherosclerosis via elevating the second messenger cyclic AMP (cAMP). |
abs813348 |
OC000459 |
5mg,10mg,25mg,50mg |
靶点: Prostaglandin Receptor |
OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM). |
abs817305 |
Prostaglandin E1 |
1mg,5mg,10mg |
靶点: Prostaglandin Receptor |
Prostaglandin E1 (Alprostadil) is a prostaglandin, which is used in the treatment of erectile dysfunction and has vasodilatory properties. |
abs819421 |
Prostaglandin E2 |
5mg,50mg |
靶点: Prostaglandin Receptor |
Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. |
abs810671 |
Bortezomib |
5mg,100mg,1g |
靶点: Proteasome |
Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. |
abs815899 |
Celastrol |
10mg,25mg,50mg,100mg |
靶点: Proteasome |
Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. |
abs812072 |
Epoxomicin |
1mg,5mg,10mg |
靶点: Proteasome |
Epoxomicin(BU-4061T)是从放线菌中分离出的抗肿瘤化合物,是20S蛋白酶体的选择不可逆抑制剂。 |
abs817874 |
MG-132 |
5mg,10mg,50mg,100mg |
靶点: Proteasome |
MG-132是一种蛋白酶体抑制剂,IC50为100 nM。还能抑制钙蛋白酶,IC50为1.2 μM。 |
abs810532 |
Dabrafenib |
5mg,10mg,50mg,100mg |
靶点: Raf |
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3. |
abs817880 |
Sorafenib |
10mg,50mg,100mg,1mL*10mM(DMSO),500mg |
靶点: Raf |
Sorafenib是Raf-1, B-Raf和VEGFR-2等的多重激酶抑制剂,IC50分别为6 nM, 22 nM和90 nM。 |
abs810719 |
Sorafenib Tosylate |
5mg,100mg |
靶点: Raf |
Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. |
abs810221 |
Azeliragon(PF-04494700,TTP488) |
5mg,10mg,50mg,100mg |
靶点: RAGE |
Azeliragon is an oral, small-molecule inhibitor of RAGE. |
abs812855 |
Tretinoin |
10mg,200mg |
靶点: RAR/RXR |
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE). |
abs812880 |
ZCL 278 |
10mg,25mg,50mg,100mg |
靶点: Ras |
ZCL278 是一种选择性的 Cdc42 调节剂,直接结合到 Cdc42,且抑制其功能,Kd 为 11.4 μM。 |
abs813820 |
Sodium ascorbate |
50mg,200mg |
靶点: Reactive Oxygen Species |
Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement. |
abs810874 |
Azidothymidine (AZT) |
100mg,25mg,200mg |
靶点: Reverse Transcriptase |
Zidovudine is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines.。 |
abs814803 |
Pyridoxal phosphate |
500mg,1g |
靶点: Reverse Transcriptase;Endogenous Metabolite |
Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. |
abs817938 |
Lamivudine |
10mg,50mg,100mg |
靶点: Reverse Transcriptase;HIV |
Lamivudine (拉米夫定) 为核苷类似物,是逆转录酶抑制剂,IC50为2.7 mM。 |
abs810493 |
Necrostatin-1 |
5mg,10mg,50mg,100mg |
靶点: RIP Kinase |
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. |
abs812079 |
Fasudil hydrochloride |
200mg,500mg |
靶点: ROCK |
Fasudil Hydrochloride (盐酸法舒地尔; HA-1077; AT-877) 能抑制ROCK-II,PKA,PKG,PKC和MLCK,Ki分别为0.33 μM,1.6 μM,1.6 μM,3.3 μM和36 μM。 |
abs810456 |
Thiazovivin |
5mg,50mg |
靶点: ROCK |
Thiazovivin is a rock inhibitor and enhances fibroblast reprogramming efficiency to generate stem cells |
abs812864 |
Y-27632 |
5mg,10mg,50mg |
靶点: ROCK |
Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over Others kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
abs810640 |
Y-27632 2HCl |
5mg,50mg |
靶点: ROCK |
Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM. |
abs810473 |
DAPT |
5mg,10mg,50mg |
靶点: secretase;Autophagy |
DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma. |
abs811980 |
GSK-872 |
5mg,10mg,25mg,50mg |
靶点: Ser/Thr Protease |
GSK-872 is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity. |
abs819464 |
Parthenolide |
50mg,200mg |
靶点: Sesquiterpenoids |
Parthenolide is an NF-κB inhibitor, reduces histone deacetylase 1 (HDAC-1) and DNA methyltransferase 1 independent of NF-κB inhibition. |
abs810051 |
SHP099 hydrochloride |
5mg,25mg,100mg |
靶点: SHP |
SHP099 exhibits dose-dependent pathway inhibition and antitumor activity in xenograft models. SHP-099 stabilizes SHP2 in an auto-inhibited conformation, concurrently binds to the interface of the N-terminal SH2, C-terminal SH2, and protein tyrosine phosphatase domains, thus inhibiting SHP2 activity through an allosteric mechanism. SHP099 suppresses RAS–ERK signaling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro and is efficacious in mouse tumor xenograft models. SHP099’s activity provides evidence that pharmacological inhibition of SHP2 is a viable strategy to target RTK-driven cancers and presents a new chemical tool for further interrogation of the multifaceted cellular functions of SHP2 in development, tumorigenesis, RTK-driven drug resistance and immune-checkpoint modulation.SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1). Because it is an oncoprotein associated with multiple cancer-related diseases, as well as a potential immunomodulator, controlling SHP2 activity is of significant therapeutic interest. |
abs814581 |
3-TYP |
5mg,50mg |
靶点: Sirtuin |
3-TYP is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively. |
abs812154 |
EX-527 |
5mg,10mg,25mg |
靶点: Sirtuin |
EX-527 (Selisistat)是一种有效的,选择性SIRT1抑制剂,无细胞试验中IC50为38 nM,比作用于SIRT2和SIRT3选择性高200倍以上。 |
abs816969 |
Nicotinamide |
50mg,100mg,200mg,500mg |
靶点: Sirtuin |
Nicotinamide (Vitamin B3), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an activator of sirtuins. |
abs810572 |
Tenovin-6 |
5mg,10mg,50mg,100mg |
靶点: Sirtuin |
Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator. |
abs810337 |
Purmorphamine |
5mg,10mg,50mg,100mg |
靶点: Smo |
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM. |
abs812956 |
Smoothened Agonist (SAG) |
2mg,5mg |
靶点: Smo |
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). |
abs813536 |
Camostat Mesilate |
50mg,200mg,1g |
靶点: Sodium Channel |
Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase. |
abs813304 |
Riluzole |
25mg,50mg,100mg,200mg |
靶点: Sodium Channel |
Riluzole用于治疗肌萎缩性侧索硬化症。 |
abs820248 |
EIPA |
5mg |
靶点: Sodium Channel;TRP Channel |
EIPA is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
abs810398 |
PP2 |
5mg,50mg |
靶点: Src |
PP2 is Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA. |
abs816685 |
Fluoxetine hydrochloride |
25mg,50mg,100mg,200mg |
靶点: SSRIs |
Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
abs814103 |
BP-1-102 |
5mg,10mg,50mg,100mg |
靶点: STAT |
BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, binds Stat3 with an affinity Kd of 504 nM and blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM. |
abs813012 |
Colivelin |
500μg,1mg |
靶点: STAT |
Colivelin is a neuroprotective peptide and activator of STAT3. It is able to protect neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. It also suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and improves memory impairment in Alzheimer's disease (AD) models. |
abs817878 |
Fludarabine |
5mg,10mg,25mg,50mg |
靶点: STAT |
Fludarabine是一种STAT1活性抑制剂和DNA合成抑制剂。 |
abs810148 |
Napabucasin (BBI608) |
5mg,10mg,50mg,100mg |
靶点: STAT |
Napabucasin (BBI608) is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells. |
abs810740 |
S3I-201 |
5mg,50mg |
靶点: STAT |
S3I-201 (NSC 74859) is a Stat3 inhibitor with IC50 of 86 μM. |
abs812053 |
Stattic |
10mg,50mg |
靶点: STAT |
Stattic是STAT3的有效抑制剂,主要用于癌症的治疗。 |
abs816876 |
Cholesterol |
10mg,25mg,100mg,50mg |
靶点: Steroids |
Cholesterol is the major sterol in mammals, and its importance in fundamental cellular processes is becoming more appreciated. |
abs814362 |
GK921 |
10mg,50mg |
靶点: Tgase |
GK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 uM in cancer cell lines. |
abs817882 |
LY2109761 |
2mg,10mg,25mg,50mg |
靶点: TGF-β |
LY2109761是一种新型的,选择性的TGF-β receptor type I/II (TβRI/II)双重抑制剂,Ki分别为38 nM和300 nM,同时也抑制Smad2的磷酸化。 |
abs812862 |
Pirfenidone |
50mg,100mg |
靶点: TGF-β |
Pirfenidone抑制TGF-β产生和TGF-β刺激的胶原蛋白产生,且降低TNF-α和IL-1β产量,具有抗纤维化和抗炎特性。 |
abs817694 |
A-83-01 |
5mg,10mg,25mg,50mg |
靶点: TGF-β Receptor |
A-83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 nM, 45 nM and 7.5 nM, respectively. |
abs810528 |
LDN193189 |
5mg,10mg,50mg,100mg |
靶点: TGF-β Receptor |
LDN193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively. |
abs810511 |
LY2157299 |
5mg,10mg,50mg,100mg,500mg |
靶点: TGF-β Receptor |
LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2. |
abs810425 |
LY-364947 |
5mg,10mg,50mg,100mg |
靶点: TGF-β Receptor |
LY-364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, shows 7-fold selectivity over TGFβR-II. |
abs810481 |
SB-431542 |
5mg,10mg,50mg |
靶点: TGF-β Receptor |
SB-431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases. |
abs810389 |
SB-505124 |
5mg,10mg,50mg,100mg |
靶点: TGF-β Receptor |
SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6. |
abs810374 |
SB525334 |
2mg,5mg,10mg,50mg |
靶点: TGF-β Receptor |
SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6. |
abs812105 |
SIS3 HCl |
2mg,5mg,10mg |
靶点: TGF-β/Smad |
SIS3是一种新型的特异性Smad3抑制剂,通过抑制Smad3的磷酸化抑制TGF-β和activin信号,而不影响MAPK/p38, ERK或PI3-kinase信号通路。 |
abs817911 |
AEBSF hydrochloride |
50mg,100mg,1ml*10mM(DMSO),200mg |
靶点: Thrombin |
AEBSF是水溶性的,不可逆的丝氨酸蛋白酶抑制剂,抑制蛋白酶如胰凝乳蛋白酶,激肽释放酶,血纤维蛋白溶酶,凝血酶,胰蛋白酶。 |
abs816274 |
Trifluorothymidine |
25mg,50mg,100mg,200mg |
靶点: Thymidylate Synthase |
Trifluridine (Viroptic) is an anti-herpesvirus antiviral drug, used primarily on the eye. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing. |
abs812870 |
Liothyronine sodium |
50mg,100mg,250mg |
靶点: Thyroid Hormone Receptor |
3,3',5-Triiodo-L-thyronine sodium 是一种有效的甲状腺激素 (thyroid hormone),可以结合并激活 β1甲状腺激素受体 (TRβ1)。 |
abs816930 |
L-Thyroxine |
5mg,25mg,100mg |
靶点: Thyroid Hormone Receptor |
L-Thyroxine(Levothyroxine) is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells; reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. |
abs810694 |
Resiquimod |
5mg,10mg,50mg,100mg |
靶点: TLR |
Resiquimod (R-848; S28463) is a potent synthetic agonist of TLR7/TLR8 that possesses antiviral and antitumoral activities. |
abs814050 |
TAK-242 (Resatorvid) |
5mg,10mg,50mg |
靶点: TLR |
TAK-242 (Resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. |
abs810732 |
Lenalidomide |
5mg,50mg |
靶点: TNF-alpha |
Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. |
abs817509 |
Pomalidomide |
5mg,10mg,50mg,100mg |
靶点: TNF-alpha |
Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. |
abs812889 |
Ciprofloxacin |
10mg,50mg,100mg,200mg |
靶点: Topoisomerase |
Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM. |
abs817233 |
Adriamycin |
10mg,50mg |
靶点: Topoisomerase |
Doxorubicin is an Anthracycline Topoisomerase Inhibitor. The mechanism of action of doxorubicin is as a Topoisomerase Inhibitor. The chemical classification of doxorubicin is Anthracyclines. |
abs810716 |
Doxorubicin hydrochloride |
5mg,50mg |
靶点: Topoisomerase |
Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. |
abs812962 |
Etoposide |
50mg,100mg,200mg,500mg |
靶点: Topoisomerase |
Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
abs817737 |
Salirasib |
5mg,10mg,25mg,50mg |
靶点: Transferase |
Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2. |
abs812984 |
Astragaloside IV |
10mg,50mg,100mg |
靶点: Triterpenoids |
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 µM; LC50 = 865 µM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts. |
abs813345 |
HC-030031 |
5mg,10mg,50mg,100mg |
靶点: TRP Channel |
HC-030031是一种选择性的TRPA1通道阻断剂,可以拮抗AITC和formalin引起的钙流入,IC50分别为6.2μM和5.3μM。HC-030031能快速且可逆阻断AITC或Formalin引起的内向和外向电流,也能抑制N-methylmaleimide和Electrophillic前列腺素引起的TRPA1激活。HC-030031不抑制TRPV1, TRPV3, TRPV4 hERG, 或NaV1.2通道介导的电流。 |
abs817037 |
Metronidazole |
25mg,200mg |
靶点: URAT1 |
Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. |
abs815860 |
Atosiban |
50mg,500mg |
靶点: Vasopressin Receptor |
Atosiban(RW22164; Tractocile)为九肽,是desamino-oxytocin类似物,是竞争性加压素/催产素受体拮抗剂,能抑制催产素介导的三磷酸肌醇从子宫肌层细胞膜上释放。 |
abs816342 |
Tolvaptan |
10mg,25mg,50mg,100mg |
靶点: Vasopressin Receptor |
Tolvaptan (OPC-41061)?is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28uM for the inhibition of AVP-induced platelet aggregation. Tolvaptan (OPC-41061) is used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan (OPC-41061) is also in fast-track clinical trials for polycystic kidney disease. Treatment with t tolvaptan (OPC-41061) causes rapid and sustained body weight reductions concurrent with increases in urine output, improves and/or normalizes serum sodium in hyponatremic patients, reduces signs and symptoms of congestion and increases thirst. However, tolvaptan (OPC-41061) has not been shown to decrease heart failure re-hospitalization or mortality. As an adjunct to standard therapy, tolvaptan (OPC-41061) is unique in that it is virtually the only novel agent tested in patients hospitalized for acute heart failure syndrome (AHFS) to reach its primary end point for short-term efficacy without causing deleterious side effects. |
abs816022 |
Vitamin D3 |
25mg,100mg,50mg |
靶点: VD/VDR |
Vitamin D3 是维生素D的一种, 结合并激活H305F/H397Y突变型维生素D 受体(VDR),EC50 为300 nM. |
abs810744 |
Erastin |
5mg,10mg,50mg,100mg |
靶点: VDAC |
Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. |
abs810179 |
Apatinib |
5mg,50mg |
靶点: VEGFR |
Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. |
abs814025 |
Apatinib Mesylate |
5mg,50mg,5g |
靶点: VEGFR |
Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM. |
abs813181 |
Axitinib |
25mg,50mg,100mg,200mg,1g |
靶点: VEGFR |
Axitinib是一种多靶点抑制剂,作用于VEGFR-1, VEGFR-2,VEGFR-3,PDGFR-β和c-KIT时,其IC50分别为0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM和1.7 nM。Axitinib是受体激酶抑制剂,作用于VEGFR-1, VEGFR-2,VEGFR-3, PDGFR-β和c-KIT时IC50分别为0.1 , 0.2, 0.1-0.3, 1.6 和1.7 nM 。Axitinib可以阻断VEGFR的自磷酸化作用,VEGF调节的内皮细胞活力,微管形成,及下游信号。Axitinib抑制多种细胞系的增殖,如作用于IGR-N91, IGR-NB8, SH-SY5Y ,无VEGF刺激的HUVEC时IC50分别为>1000 nM, 849 nM, 274 nM和573 nM。 |
abs810651 |
E-7080(Lenvatinib) |
5mg,50mg |
靶点: VEGFR |
E7080 (Lenvatinib; Vargatef) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β. |
abs810672 |
Regorafenib (BAY 73-4506) |
5mg,10mg,50mg,100mg,1g |
靶点: VEGFR;RET;PDGFR;Autophagy;Raf |
Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
abs817347 |
Trolox |
50mg,100mg,200mg,500mg |
靶点: Vitamin |
Troloxa is a vitamin E analogue, used in reducing oxidative stress or damage. |
abs810693 |
Adavosertib |
5mg,10mg,25mg,50mg,1g,5g,10g |
靶点: Wee1 |
MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 (IC50: 5.2 nM, in a cell-free assay); hinders G2 DNA damage checkpoint. Adavosertib selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. |
abs810509 |
IWP-2 |
5mg,50mg |
靶点: Wnt |
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. |
abs810444 |
IWR-1 endo |
5mg,10mg,50mg,100mg |
靶点: Wnt |
IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
abs812851 |
Wnt agonist 1 |
5mg,50mg |
靶点: Wnt |
Wnt Agonist is a cell-permeable pyrimidine compound that acts as, at an IC50 > 60 μM, a potent and selective activator of Wnt signaling. In addition to mimicking the effect of Wnt, Wnt Agonist has also induced β-catenin and T-cell fate-dependent transcriptional activity in HEK-293T cells at an EC50 = 700 nM. When applied to Xenopous embryos Wnt Agonist caused substantial head defects development. Wnt Agonist has also been observed to enhance beta cell expansion in vitro. The compound is beneficial for studying the effects of Wnt pathway due to the activation of Wnt without inhibiting the activity of GSK-3β. |
abs810639 |
Wnt-C59 |
5mg,10mg,50mg,100mg |
靶点: Wnt;Porcupine |
Wnt-C59(C59) is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. |
abs810355 |
FH535 |
5mg,50mg |
靶点: Wnt;PPAR;β-catenin |
FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. |
abs810648 |
XAV-939 |
5mg,10mg,25mg,50mg |
靶点: β-catenin;PARP |
XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM, regulates axin levels and does not affect CRE, NF-κB or TGF-β. |
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