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  • Recombinant Human TIGIT Fc Chimera

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    • TIGIT Fc Chimera蛋白,Recombinant Human TIGIT Fc Chimera,T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, Tigit, VSIG9, VSTM3
    货号: abs05031
    产品说明书
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    货号-规格 货期 价格 数量
    abs05031-25μg 现货 ¥800.00 ¥560.00
    - +
    abs05031-100μg 现货 ¥2000.00 ¥1400.00
    - +
    大包装询价
    概述
    别名
    TIGIT Fc Chimera蛋白;T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, Tigit, VSIG9, VSTM3
    种属
    human
    来源
    HEK293
    分子量
    45-49KDa(Reducing)
    外观
    Lyophilized Powder
    形态
    Lyophilized from a 0.22 μm filtered solution of PBS, 5% trehalose, pH 7.2.
    性能
    序列
    Met22-Pro141
    标签
    C-Fc
    纯度
    >95% by SDS-PAGE(Reducing)&SEC-HPLC
    内毒素水平
    <0.1 EU/μg (gel-clot)
    标记
    unconjugated
    溶解方法
    Centrifuge tubes before opening.Reconstitute no more than 1 mg/mL according to the size in deionized water.
    储存/保存方法
    Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
    注意事项
    This product contains 5% trehalose, if you need recombinant protein without added trehalose, please contact us.
    靶标
    背景说明
    TIGIT (T cell Ig and ITIM domain, also known as WUCAM, Vstm3, VSIG9) is a member of the poliovirus receptor (PVR)/Nectin family. It consists of an extracellular immunoglobulin variable region (IgV) domain, a type 1 transmembrane domain and has a classical immunoreceptor tyrosine inhibitory motif (ITIM) and immunoglobulin tyrosine tail (ITT) motifs of intracellular domains. TIGIT is expressed in lymphocytes, especially effector and regulatory CD4+ T cells, follicular helper CD4+ T cells, effector CD8+ T cells and natural killer (NK) cells. CD155 (also called PVR, Necl5 or Tage4) is a high-affinity ligand of TIGIT. IGIT inhibits the activity of the immune system by binding to CD155 highly expressed on the tumor surface. This product is a human TIGIT recombinantly expressed by HEK293 cells, fused with human IgG1 Fc Recombinant protein is made by sterilizing filtration after multi-step purification, adding 5% trehalose, and sub-packaging and lyophilizing.
    Accession
    Q495A1
    2μg (NR: non-reducing conditions, R: reducing conditions).
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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