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  • Recombinant Human PD-L1 His Tag

    全线7折
    • PD-L1蛋白,Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1 Ligand 1, Programmed Death Ligand 1, B7 Homolog 1, B7-H1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
    货号: abs04722
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs04722-25μg 现货 ¥800.00
    - +
    abs04722-100μg 现货 ¥2000.00 ¥1400.00
    - +
    大包装询价
    概述
    别名
    PD-L1蛋白;Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1 Ligand 1, Programmed Death Ligand 1, B7 Homolog 1, B7-H1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
    种属
    human
    来源
    HEK293
    分子量
    30-35 KD(Reducing)
    外观
    Lyophilized Powder
    形态
    Lyophilized from a 0.22 μm filtered solution of PBS, 5% trehalose, pH 7.2.
    性能
    序列
    Phe19-Arg238
    标签
    C-6His
    纯度
    >95% by SDS-PAGE(Reducing)
    内毒素水平
    <0.1 EU/μg (gel-clot)
    标记
    unconjugated
    溶解方法
    Centrifuge tubes before opening.Reconstitute no more than 1 mg/mL according to the size in deionized water.
    储存/保存方法
    Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
    注意事项
    This product contains 5% trehalose, if you need recombinant protein without added trehalose, please contact us.
    靶标
    背景说明
    Programmed cell death 1 ligand 1 (PD-L1) is a type 1 transmembrane protein expressed in humans with a size of 40 kDa and is believed to be immune diseases, as well as certain diseases such as hepatitis), is related to the suppression of the immune system. Under normal circumstances, the immune system will react to foreign antigens accumulated in the lymph nodes or spleen, promoting the proliferation of antigen-specific cytotoxic T cells (CD8+ T cells). The programmed cell death receptor-1 (PD-1) binds to programmed cell death-ligand 1 (PD-L1), which can transmit inhibitory signals and reduce the proliferation of lymph node CD8+ T cells, and PD-1 can also This regulates the Bcl-2 gene and controls the accumulation of antigen-specific T cells in lymph nodes. This product is made by HEK293 cell line expressing human PD-L1, C-6His recombinant protein, after multi-step purification, filtering, adding 5% trehalose, and freeze-drying.
    Accession
    Q9NZQ7
    1μg (NR: non-reducing conditions, R: reducing conditions).
    When PD-L1 His tag, Human is immobilized at 2.8µg/mL, it binds to PD-1 Fc Chimera, Human with an EC50 of 4.334-5.695µg/mL.
    PD-L1 His Tag, Human (Cat. No. abs04722) captured on CM5 chip via, can bind PD-1 Fc Chimera, Human (Cat. No. abs04721) with an affinity constant of 0.1836 μM as determined in a SPR assay (Biacore T200).
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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