Recombinant Human PD-L1 Fc Chimera

PD-L1 Fc Chimera蛋白;Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1 Ligand 1, Programmed Death Ligand 1, B7 Homolog 1, B7-H1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1

human

HEK293

65-70 kDa (Reducing)

Lyophilized Powder

Lyophilized from a 0.22 μm filtered solution of PBS, 5% trehalose, pH 7.2.

Phe19-Arg238

C-Fc

＞95% by SDS-PAGE(Reducing)

＜0.1 EU/μg (gel-clot)

unconjugated

Centrifuge tubes before opening.Reconstitute no more than 1 mg/mL according to the size in deionized water.

Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.

This product contains 5% trehalose, if you need recombinant protein without added trehalose, please contact us.

Programmed cell death 1 ligand 1 (PD-L1) is a type 1 transmembrane protein expressed in humans with a size of 40 kDa and is believed to be immune diseases, as well as certain diseases such as hepatitis), is related to the suppression of the immune system. Under normal circumstances, the immune system will react to foreign antigens accumulated in the lymph nodes or spleen, promoting the proliferation of antigen-specific cytotoxic T cells (CD8+ T cells). The programmed cell death receptor-1 (PD-1) binds to programmed cell death-ligand 1 (PD-L1), which can transmit inhibitory signals and reduce the proliferation of lymph node CD8+ T cells, and PD-1 can also This regulates the Bcl-2 gene and controls the accumulation of antigen-specific T cells in lymph nodes. This product is made by HEK293 cell line expressing human PD-L1 and fused with human IgG1 Fc recombinant protein, after multi-step purification, filtering, adding 5% trehalose, and lyophilizing.

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