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  • Recombinant Human PD-1 His Tag

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    • PD-1蛋白,Programmed cell death protein 1,hPD-1,PDCD1,CD279
    货号: abs05023
    产品说明书
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    货号-规格 货期 价格 数量
    abs05023-25μg 现货 ¥800.00
    - +
    abs05023-100μg 现货 ¥2000.00 ¥1400.00
    - +
    大包装询价
    概述
    别名
    PD-1蛋白;Programmed cell death protein 1,hPD-1,PDCD1,CD279
    种属
    Human
    来源
    HEK293
    分子量
    28-36 kDa (Reducing)
    外观
    Lyophilized Powder
    形态
    Lyophilized from a 0.22 μm filtered solution of PBS, 5% trehalose, pH 7.4.
    性能
    序列
    Leu25-Gln167
    标签
    C-6His
    纯度
    >95% by SDS-PAGE(Reducing)
    内毒素水平
    <0.1 EU/μg (gel-clot)
    标记
    unconjugated
    溶解方法
    Centrifuge tubes before opening.Reconstitute no more than 1 mg/mL according to the size in deionized water.
    储存/保存方法
    Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
    注意事项
    This product contains 5% trehalose, if you need recombinant protein without added trehalose, please contact us.
    靶标
    背景说明
    PD-1 (programmed death 1) programmed death receptor 1 is an important immunosuppressive molecule, belonging to the immunoglobulin superfamily, and is a membrane protein of 268 amino acid residues. Immunomodulation targeting PD-1 is of great significance in anti-tumor, anti-infection, anti-autoimmune diseases and organ transplantation survival. Its ligand PD-L1 can also be used as a target. The combination of PD-1 and PD-L1 initiates the programmed death of T cells and enables tumor cells to obtain immune escape. This product is made from HEK293 cell line expressing human PD-1, C-6His recombinant protein, after multi-step purification, filtering, adding 5% trehalose, and lyophilizing.
    Accession
    Q15116
    1μg (NR: non-reducing conditions, R: reducing conditions).
    Immobilized PD-1 His Tag, Human (Cat. No. abs05023) at 1.5μg/mL (100μL/well) can bind PD-L1 Fc Chimera, Human (Cat. No. abs05024) with an EC50 of 0.141-0.174µg/mL.
    PD-1 His Tag, Human (Cat. No. abs05023) captured on CM5 chip via, can bind PD-L1 Fc Chimera, Human (Cat. No. abs05024) with an affinity constant of 0.6644 μM as determined in a SPR assay (Biacore T200).
    Loaded PD-L1 Fc Chimera, Human (Cat. No. abs05024) on Protein A Biosensor, can bind PD-1 His Tag, Human (Cat. No. abs05023) with an affinity constant of 1.6 μM as determined in BLI assay.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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