Recombinant Human CD47 His Tag

CD47 蛋白;antigen identified by monoclonal 1D8, Antigenic surface determinant protein OA3, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 antigen, CD47 glycoprotein, CD47 molecule, CD47, IAP, IAPintegrin associated protein, Integrin-associated protein, leukocyte surface antigen CD47, MER6, MER6integrin-associated signal transducer, OA3, Protein MER6, Rh-related antigen

human

HEK293

33-45 kDa(Reducing)

Lyophilized Powder

Lyophilized from a 0.22 μm filtered solution of PBS, 5% trehalose, pH 7.2.

Gln19-Pro139

C-6His

＞95% by SDS-PAGE(non-Reducing)

＜0.2 EU/μg(gel-clot)

unconjugated

Centrifuge tubes before opening.Reconstitute no more than 1 mg/mL according to the size in deionized water.

Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.

This product contains 5% trehalose, if you need recombinant protein without added trehalose, please contact us.

The leukocyte surface antigen CD47, also known as integrin-associated protein (IAP), is a typical representative of the "marker of self" among all cell-expressed targets. CD47 is a 52 kDa glycoprotein with an immunoglobulin variable N-terminal domain, 5 transmembrane domains and a short C-terminal intracellular tail with four alternatively different splicing isoforms, resulting in 4 subtypes are formed. CD47 is an immune cell group that plays a major role in targeted tumor immunotherapy. CD47 expressed by cancer cells interacts with SIRP family proteins SIRPα and SIRPγ expressed by NK cells to protect cancer cells from being phagocytosed and eliminated in this way. CD47 is highly expressed on a variety of solid tumor cells and malignant hematological tumor cells, and its expression level is positively correlated with disease progression. This product is made from human CD47 recombinantly expressed by HEK293 cell line, added with 5% trehalose, and lyophilized.

Q08722