首页 产品中心
  • Recombinant Human B7-H3/CD276 His Tag

    全线7折
    • B7-H3蛋白, CD276蛋白,Recombinant Human B7-H3/CD276 His Tag,B7H3, B7-H3, CD276 antigen, CD276 molecule, CD276, B7H34Ig-B7-H3, B7-H3B7 homolog 3, Costimulatory molecule
    货号: abs05030
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs05030-25μg 现货 ¥800.00 ¥560.00
    - +
    abs05030-100μg 现货 ¥2000.00 ¥1400.00
    - +
    大包装询价
    概述
    别名
    B7-H3蛋白, CD276蛋白;B7H3, B7-H3, CD276 antigen, CD276 molecule, CD276, B7H34Ig-B7-H3, B7-H3B7 homolog 3, Costimulatory molecule
    种属
    human
    来源
    HEK293
    分子量
    38-48 kDa(Reducing)
    外观
    Lyophilized Powder
    形态
    Lyophilized from a 0.22 μm filtered solution of PBS, 5% trehalose, pH 7.2.
    性能
    序列
    Leu29-Pro245
    标签
    C-10His
    纯度
    >95% by SDS-PAGE(Reducing)&SEC-HPLC
    内毒素水平
    <0.1 EU/ug(gel-clot)
    标记
    unconjugated
    溶解方法
    Centrifuge tubes before opening.Reconstitute no more than 1 mg/mL according to the size in deionized water.
    储存/保存方法
    Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
    注意事项
    This product contains 5% trehalose, if you need recombinant protein without added trehalose, please contact us.
    靶标
    背景说明
    B7-H3 (B7 homolog 3 protein), also known as CD276, is an important immune checkpoint molecule of the B7-CD28 family. is a type I transmembrane glycoprotein composed of 316 amino acids containing a putative 28AA signal peptide, a 217AA extracellular domain consisting of immunoglobulin constant (IgC) and variable (IgV) structures, a transmembrane domain and 45 amino acid cytoplasmic domain. B7-H3 is a T cell co-suppressive molecule with partial co-stimulatory functions. B7-H3 can effectively inhibit the function of T cells and NK cells, and also has an effect on bone development. The expression of B7-H3 is low in normal tissues, and it is expressed in a variety of malignant tumors. It is closely related to the growth, metastasis, recurrence, and poor prognosis of malignant tumors. B7-H3 can down-regulate T helper type 1-mediated immune responses, inhibit CD4+ T cell activation, and inhibit the production of cytokines, which may play a role in promoting cancer cell immune escape. This product is made by recombinant expression of human B7-H3/CD276 in HEK293 cells, after multi-step purification, sterilization, filtration, adding 5% trehalose, and lyophilizing.
    Accession
    Q5ZPR3-2
    1μg (R: reducing conditions).
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
      0张,还能上传 8 提交
          提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要咨询”按钮填写您的疑问。
          提交不成功?请联系info@absin.cn。
          我要咨询

      促销资讯 更多

        订购信息
        您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
        GO
        • 0