Recombinant Human B7-H3/CD276 His Tag

B7-H3蛋白, CD276蛋白;B7H3, B7-H3, CD276 antigen, CD276 molecule, CD276, B7H34Ig-B7-H3, B7-H3B7 homolog 3, Costimulatory molecule

human

HEK293

38-48 kDa(Reducing)

Lyophilized Powder

Lyophilized from a 0.22 μm filtered solution of PBS, 5% trehalose, pH 7.2.

Leu29-Pro245

C-10His

＞95% by SDS-PAGE(Reducing)&SEC-HPLC

＜0.1 EU/ug(gel-clot)

unconjugated

Centrifuge tubes before opening.Reconstitute no more than 1 mg/mL according to the size in deionized water.

Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.

This product contains 5% trehalose, if you need recombinant protein without added trehalose, please contact us.

B7-H3 (B7 homolog 3 protein), also known as CD276, is an important immune checkpoint molecule of the B7-CD28 family. is a type I transmembrane glycoprotein composed of 316 amino acids containing a putative 28AA signal peptide, a 217AA extracellular domain consisting of immunoglobulin constant (IgC) and variable (IgV) structures, a transmembrane domain and 45 amino acid cytoplasmic domain. B7-H3 is a T cell co-suppressive molecule with partial co-stimulatory functions. B7-H3 can effectively inhibit the function of T cells and NK cells, and also has an effect on bone development. The expression of B7-H3 is low in normal tissues, and it is expressed in a variety of malignant tumors. It is closely related to the growth, metastasis, recurrence, and poor prognosis of malignant tumors. B7-H3 can down-regulate T helper type 1-mediated immune responses, inhibit CD4+ T cell activation, and inhibit the production of cytokines, which may play a role in promoting cancer cell immune escape. This product is made by recombinant expression of human B7-H3/CD276 in HEK293 cells, after multi-step purification, sterilization, filtration, adding 5% trehalose, and lyophilizing.

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