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  • Recombinant Cynomolgus MMP-8 Protein(His Tag)

    自产金标
    • MMP-8; CLG1; HNC; PMNL-CL
    货号: abs05322
    产品说明书
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    货号-规格 货期 价格 数量
    abs05322-100ug 1-2周 ¥4200.00
    - +
    abs05322-500ug 1-2周 ¥15000.00
    - +
    大包装询价
    概述
    别名
    MMP-8; CLG1; HNC; PMNL-CL
    种属
    Cynomolgus
    来源
    HEK293
    分子量
    65-75 kDa
    外观
    Lyophilized Powder
    形态
    Lyophilized from PBS, pH7.4
    性能
    序列
    Phe21-Ser467, with C-terminal 10*His
    FPVSSKEENTKIVQDYLEKFYQLPSNQYQSTRKNGTSMIVEKLKEMQRFFGLNVTGKPNEETLDIMKKPRCGVPDSGDFMLTPGNPKWERTNLTYSILNYTPQLSETDVEGAIKKAFEVWSKASPLTFTRISQGQADINIAFFQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTKNSTNYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDINGIQAIYGPSSNPIQPTGPTTPKSCDPRLTFDAITTLRGEILFFKDEYFWRRHPHLQSVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWAVSGYDIQQGYPRDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGTFPGIENKVDAVFQQEHFFLFFSGPRYYAFDLIAERVTRVARANKWLNCRYSGGGSGGGSHHHHHHHHHH
    标签
    His Tag
    纯度
    >95% by SDS-PAGE
    内毒素水平
    <0.1EU/ug
    溶解方法
    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
    储存/保存方法
    Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
    靶标
    背景说明
    A protease is an enzyme with a proteolytic activity that facilitates the digestion of its substrates. Membrane-type I matrix metalloproteinase (MT1-MMP), a member of the broader matrix metalloproteinases (MMP) family, is involved in the regulation of diverse cellular activities. Parasite-derived products have been shown to regulate host matrix metalloproteinases (MMPs), contributing to CE pathogenesis and progressive liver fibrosis in intermediate hosts. The current study aimed to investigate the potential role of MMP1, 7, 8, and 13 in E. granulosus induced liver fibrosis.MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumor may have a protective effect against lymph node metastasis.
    Accession
    XP_005579523.2
    参考文献
    参考文献
    1、Hasty K A. et al. (1990) Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J. Biol. Chem. 265: 11421-11424.2、Blaeser J. et al. (1991) Mercurial activation of human polymorphonuclear leucocyte procollagenase. Eur. J. Biochem. 202: 1223-1230.
    1μg (R: reducing conditions, N: non-reducing conditions).
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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