Recombinant Cynomolgus MMP-8 Protein(His Tag)

MMP-8; CLG1; HNC; PMNL-CL

Cynomolgus

HEK293

65-75 kDa

Lyophilized Powder

Lyophilized from PBS, pH7.4

Phe21-Ser467, with C-terminal 10*His
FPVSSKEENTKIVQDYLEKFYQLPSNQYQSTRKNGTSMIVEKLKEMQRFFGLNVTGKPNEETLDIMKKPRCGVPDSGDFMLTPGNPKWERTNLTYSILNYTPQLSETDVEGAIKKAFEVWSKASPLTFTRISQGQADINIAFFQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTKNSTNYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDINGIQAIYGPSSNPIQPTGPTTPKSCDPRLTFDAITTLRGEILFFKDEYFWRRHPHLQSVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWAVSGYDIQQGYPRDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGTFPGIENKVDAVFQQEHFFLFFSGPRYYAFDLIAERVTRVARANKWLNCRYSGGGSGGGSHHHHHHHHHH

His Tag

>95% by SDS-PAGE

<0.1EU/ug

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.

A protease is an enzyme with a proteolytic activity that facilitates the digestion of its substrates. Membrane-type I matrix metalloproteinase (MT1-MMP), a member of the broader matrix metalloproteinases (MMP) family, is involved in the regulation of diverse cellular activities. Parasite-derived products have been shown to regulate host matrix metalloproteinases (MMPs), contributing to CE pathogenesis and progressive liver fibrosis in intermediate hosts. The current study aimed to investigate the potential role of MMP1, 7, 8, and 13 in E. granulosus induced liver fibrosis.MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumor may have a protective effect against lymph node metastasis.

XP_005579523.2

1、Hasty K A. et al. (1990) Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J. Biol. Chem. 265: 11421-11424.2、Blaeser J. et al. (1991) Mercurial activation of human polymorphonuclear leucocyte procollagenase. Eur. J. Biochem. 202: 1223-1230.