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  • Rabbit anti-ZFP36L2 (Center) Polyclonal Antibody
  • Zinc finger protein 36, C3H1 type-like 2, ZFP36-like 2, Butyrate response factor 2, EGF-response factor 2, ERF-2, Protein TIS11D, ZFP36L2, BRF2, ERF2, RNF162C, TIS11D;ZFP36L2;BRF2, ERF2, RNF162C, TIS11D
  • 货号: abs113051
    产品说明书
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    货号-规格 货期 价格 数量
    abs113051-50ul 1-2周 ¥1250.00
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    大包装询价
    概述
    别名
    Zinc finger protein 36, C3H1 type-like 2, ZFP36-like 2, Butyrate response factor 2, EGF-response factor 2, ERF-2, Protein TIS11D, ZFP36L2, BRF2, ERF2, RNF162C, TIS11D;ZFP36L2;BRF2, ERF2, RNF162C, TIS11D
    宿主
    Rabbit
    特异性
    This ZFP36L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from the Central region of human ZFP36L2.
    反应种属
    Human;Mouse
    预测反应种属
    Rat, Xenopus
    应用
    WB~~1:1000
    性能
    类型
    Polyclonal Antibody
    同种型
    Rabbit Ig
    储存/保存方法
    Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
    存储溶液
    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
    研究领域
    Cell Biology;Others
    靶标
    背景说明
    mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).
    细胞定位
    Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
    UniPort
    参考文献
    参考文献
    Morgan, B.R., et al. Protein Sci. 19(6):1222-1234(2010)
    Jackson, R.S. II, et al. Cell Cycle 5(24):2889-2893(2006)
    Hudson, B.P., et al. Nat. Struct. Mol. Biol. 11(3):257-264(2004)
    Blackshear, P.J., et al. Prog. Nucleic Acid Res. Mol. Biol. 75, 43-68 (2003) :
    Ino, T., et al. Oncogene 11(12):2705-2710(1995)
    ZFP36L2 Antibody (Center) (Cat. #AP17671c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ZFP36L2 antibody detected the ZFP36L2 protein (arrow).
    ZFP36L2 Antibody (Center) (Cat. #AP17671c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ZFP36L2 antibody detected the ZFP36L2 protein (arrow).
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