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  • Rabbit anti-ZBTB33 Polyclonal Antibody
  • ZNF-kaiso;ZNF348
  • 货号: abs143461
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs143461-50ul 1-2周 ¥1250.00
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    大包装询价
    概述
    别名
    ZNF-kaiso;ZNF348
    宿主
    Rabbit
    反应种属
    Human;Mouse
    应用
    WB 1:1000 - 1:3000
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 523-672 of human ZBTB33 (NP_006768.1).
    阳性对照
    A-431,Mouse kidney
    性能
    纯化方法
    Affinity purification
    类型
    Polyclonal Antibody
    同种型
    IgG
    储存/保存方法
    Store at -20℃. Avoid freeze / thaw cycles.
    存储溶液
    Store at -20℃. Avoid freeze / thaw cycles.
    Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    靶标
    背景说明
    This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
    细胞定位
    Cytoplasm,Nucleus
    UniPort
    Western blot analysis of extracts of various cell lines, using ZBTB33 antibody (abs143461) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 90s.
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