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  • Rabbit anti-ZBTB17 Polyclonal Antibody
  • Miz-1; Myc-interacting zinc finger protein 1; Myc-interacting zinc finger protein; ZBT17; ZBT17_HUMAN; Zbtb17; Zinc finger and BTB domain containing protein 17; Zinc finger and BTB domain-containing protein 17; Zinc finger protein 151; Zinc finger protein 60; ZNF151; ZNF60;
  • 货号: abs138342
    产品说明书
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    货号-规格 货期 价格 数量
    abs138342-50ug 1-2周 ¥1100.00
    - +
    abs138342-100ug 1-2周 ¥1650.00
    - +
    大包装询价
    概述
    别名
    Miz-1; Myc-interacting zinc finger protein 1; Myc-interacting zinc finger protein; ZBT17; ZBT17_HUMAN; Zbtb17; Zinc finger and BTB domain containing protein 17; Zinc finger and BTB domain-containing protein 17; Zinc finger protein 151; Zinc finger protein 60; ZNF151; ZNF60;
    宿主
    Rabbit
    特异性
    ZBTB17 Antibody detects endogenous levels of total ZBTB17.
    反应种属
    Human;Mouse;Rat
    预测反应种属
    Rabbit;Pig;Dog;Horse;Bovine
    应用
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    免疫原
    A synthesized peptide derived from human ZBTB17.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).
    组织特异性
    Expressed in germinal center B-cells.
    翻译后修饰
    Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner.
    细胞定位
    Nucleus;
    UniPort
    Western blot analysis ZBTB17 using HeLa whole cell lysates
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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