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  • Rabbit anti-YY1 Polyclonal Antibody
  • CF1; Delta; Delta transcription factor; INO80 complex subunit S; INO80S; NF E1; NF-E1; NFE1; OTTHUMP00000197459; Transcriptional repressor protein YY1; TYY1_HUMAN; UCR motif DNA binding protein; UCRBP; Yin and yang 1; Yin and Yang 1 protein; Yin Yang 1; Ying Yang 1; YY 1; YY 1 transcription factor; YY-1; YY1; YY1 transcription factor;
  • 货号: abs137549
    产品说明书
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    货号-规格 货期 价格 数量
    abs137549-50ug 1-2周 ¥1100.00
    - +
    abs137549-100ug 1-2周 ¥1650.00
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    大包装询价
    概述
    别名
    CF1; Delta; Delta transcription factor; INO80 complex subunit S; INO80S; NF E1; NF-E1; NFE1; OTTHUMP00000197459; Transcriptional repressor protein YY1; TYY1_HUMAN; UCR motif DNA binding protein; UCRBP; Yin and yang 1; Yin and Yang 1 protein; Yin Yang 1; Ying Yang 1; YY 1; YY 1 transcription factor; YY-1; YY1; YY1 transcription factor;
    宿主
    Rabbit
    特异性
    YY1 Antibody detects endogenous levels of total YY1.
    反应种属
    Human;Mouse;Rat
    预测反应种属
    Pig;Sheep;Dog;Bovine;
    应用
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    免疫原
    A synthesized peptide derived from human YY1.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).
    翻译后修饰
    Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites.Ubiquitinated.
    细胞定位
    Nucleus;
    UniPort
    Western blot analysis YY1 using HT29 whole cell lysates
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