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  • Rabbit anti-XRN2 Polyclonal Antibody

    • XRN2抗体,5' 3' exoribonuclease 2, DHM1 like protein, DHP protein, XRN 2,
    货号: abs133731
    产品说明书
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    货号-规格 货期 价格 数量
    abs133731-50ug 1-2周 ¥1500.00
    - +
    abs133731-100ug 1-2周 ¥2300.00
    - +
    大包装询价
    概述
    别名
    XRN2抗体;5' 3' exoribonuclease 2, DHM1 like protein, DHP protein, XRN 2,
    宿主
    Rabbit
    特异性
    XRN2 Antibody detects endogenous levels of total XRN2.
    反应种属
    Human;Mouse
    应用
    WB 1:500~1:1000, IHC: 1:50~1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    分子量
    Predicted molecular weight: 109kD
    Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
    免疫原
    A synthesized peptide derived from Human XRN2(Accession Q9H0D6), corresponding to amino acid residues D103-A129.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
    组织特异性
    Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
    细胞定位
    Nucleus;
    UniProt
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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