Rabbit anti-SKP2 Polyclonal Antibody
- SKP2抗体,FBL1,FBXL1,FLB1,p45
货号: abs133836
货号-规格 | 货期 | 价格 | 数量 |
abs133836-50ul | 1-2周 | ¥1500.00 | - + |

概述 | ||
别名 | SKP2抗体;FBL1,FBXL1,FLB1,p45 | |
宿主 | Rabbit | |
反应种属 | Human,Mouse,Rat | |
应用 | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 | |
分子量 | Detects a band of approximately 48kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. | |
免疫原 | A synthetic peptide of human SKP2 | |
阳性对照 | 293T,Mouse spleen | |
性能 | ||
纯化方法 | Affinity purification | |
类型 | Polyclonal Antibody | |
同种型 | IgG | |
储存/保存方法 | Store at -20℃. Avoid freeze / thaw cycles. | |
存储溶液 | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | |
靶标 | ||
背景说明 | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. | |
细胞定位 | Cytoplasm,Nucleus | |
UniProt | ||
Immunohistochemistry of paraffin-embedded mouse liver tissue using SKP2 antibody at dilution of 1:100 (40x lens). | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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